Kaneko, T.*, Iwamura, C.*, Kiuchi, M., Kurosugi, A., Onoue, M., Matsumura, T., Chiba, T., Nakayama, T., Kato, N., and Hirahara, K.: Amphiregulin-producing TH2 cells facilitate esophageal fibrosis of eosinophilic esophagitis. (*These authors contributed equally to this work) J. Allergy Clin. Immunol. Glob. 3(3):100287 (2024).
Aoki, A.*, Iwamura, C.*, Kiuchi, M., Tsuji, K., Sasaki, A., Hishiya, T., Hirasawa, R., Kokubo, K., Kuriyama, S., Onodera, A., Shimada, T., Nagaoka, T., Ishikawa, S., Kojima, A., Mito, H., Hase, R., Kasahara, Y., Kuriyama, N., Nakamura, S., Urushibara, T., Kaneda, S., Sakao, S., Nishida, O., Takahashi, K., Kimura, M. Y., Motohashi, S., Igari, H., Ikehara, Y., Nakajima, H., Suzuki, T., Hanaoka, H., Nakada, T., Kikuchi, T., Nakayama, T., Yokote, K., and Hirahara, K.: Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Petients. (*These authors contributed equally to this work) J. Clin. Immunol. 44:104 (2024).
Hatano, R., Lee, E., Sato, H., Kiuchi, M., Hirahara, K., Nakagawa, Y., Shimano, H., Nakayama, T., Tanaka, T., and Miki, T.: Hepatic ketone body regulatioon of renal gluconeogenesis. Mol. Metab. 84:101934 (2024).
Tanaka, S., Yamamoto, T., Iwata, A., Kiuchi, M., Kokubo, K., Iinuma, T., Sugiyama, T., Hanazawa, T., Hirahara, K., Ikeda, K., and Nakajima, H.: Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease. Arthritis Res. Ther. 26(1):55 (2024).
【2023年】
Kumagai, J., Kiuchi, M., Kokubo, K., Yagyu, H., Nemoto, M., Tsuji, K., Nagahata, K., Sasaki, A., Hishiya, T., Onoue, M., Shinmi, R., Sonobe, Y., Iinuma, T., Yonekura, S., Shinga, J., Hanazawa, T., Koseki, H., Nakayama, T., Yokote, K., and Hirahara, K.: The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells. Proc. Natl. Acad. Sci. USA 120(49):e2302903120 (2023).
Suga,K., Kiuchi, M., Kageyama, T., Kokubo, K., Tanaka, S., Iwata, A., Suzuki, K., Hirahara, K., and Nakajima, H.: Single-cell RNA sequencing of peripheral blood mononuclear cells from Kimura disease patient successfully treated with dupilumab. Allergol. Int. 72(4):610-613 (2023).
Koyama-Nasu, R., Kimura, M. Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., Motohashi, S., and Nakayama, T.: CD69 imposes tumor-specific CD8+ T-cell fate in tumor-draining lymph nodes. Cancer Immunol. Res. 11(8):1085-1099 (2023).
Iinuma T., Yonekura, S., Hirahara, K., Kurita, J., Yoneda, R., Arai, T., Sonobe, Y., Shinmi, R., Okamoto, Y., and Hanazawa, T.: Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype. Allergol. Int. 72(4):564-572 (2023).
Onodera, A., Kokubo, K., Okano, M., Onoue, M., Kiuchi, M., Iwamura, C., Iinuma, T., Kimura, M. Y., Ebihara, N., Hanazawa, T., Nakayama, T., and Hirahara, K.: Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol. Ther. 247:108445 (2023).
Sato, Y., Silina, K., van den Broek, M., Hirahara, K., and Yanagita, M.: The roles of tertiary lymphoid structures in chronic diseases. Nat. Rev. Nephrol. 19:525-537 (2023).
Tsuji, K., Aoki, A., Onodera, A., Kiuchi, M., Kokubo, K., Morimoto, Y., Iinuma, T., Hanazawa, T., Nakayama, T., and Hirahara, K.: Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients. Allergol. Int. 72(2):335-338 (2023).
Kokubo, K., Hirahara, K., Kiuchi, M., Tsuji, K., Shimada, Y., Sonobe, Y., Shinmi, R., Hishiya, T., Iwamura, C., Onodera, A., and Nakayama, T.: Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Proc. Natl. Acad. Sci. USA 120(2):e2218345120 (2023).
【2022年】
Okano, M., Hirahara, K., Kiuchi, M., Onoue, M., Iwamura, C., Kokubo, K., Hishiya, T., Morimoto, Y., Ikehara, Y., Murakami, A., Ebihara, N., and Nakayama, T.: Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity 55(12):2352-2368.e7 (2022).
Fujimoto, M., Yokoyama, M., Kiuchi, M., Hosokawa, H., Nakayama, A., Hashimoto, N., Sakuma, I., Nagano, H., Yamagata, K., Kudo, F., Manabe, I., Lee, E., Hatano, R., Onodera, A., Hirahara, K., Yokote, K., Miki, T., Nakayama, T., and Tanaka, T.: Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis. Nat. Commun. 13:5408 (2022).
Iinuma, T.*, Kiuchi, M.*, Hirahara, K., Kurita, J., Kokubo, K., Yagyu, H., Yoneda, R., Arai, T., Sonobe, Y., Fukuyo, M., Kaneda, A., Yonekura, S., Nakayama, T., Okamoto, Y., and Hanazawa, T.: Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion. (*These authors contributed equally to this work) J. Allergy Clin. Immunol. 150(4):850-860.e5 (2022).
Kokubo, K., Onodera, A., Kiuchi, M., Tsuji, K., Hirahara, K., and Nakayama, T.: Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. Front. Immunol. 13:945063 (2022).
Iwamura, C., Hirahara, K., Kiuchi, M., Ikehara, S., Azuma, K., Shimada, T., Kuriyama, S., Ohki, S., Yamamoto, E., Inaba, Y., Shiko, Y., Aoki, A., Kokubo, K., Hirasawa, R., Hishiya, T., Tsuji, K., Nagaoka, T., Ishikawa, S., Kojima, A., Mito, H., Hase, R., Kasahara, Y., Kuriyama, N., Tsukamoto, T., Nakamura, S., Urushibara, T., Kaneda, S., Sakao, S., Tobiume, M., Suzuki, Y., Tsujiwaki, M., Kubo, T., Hasegawa, T., Nakase, H., Nishida, O., Takahashi, K., Baba, K., Iizumi, Y., Okaszaki, T., Kimura, M. Y., Yoshino, I., Igari, H., Nakajima, H., Suzuki, T., Hanaoka, H., Nakada, T., Ikehara, Y., Yokote, K., and Nakayama, T.: Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2-induced lung exudative vasculitis and predicts COVID-19 severity. Proc. Natl. Acad. Sci. USA 119(33):e2203437119 (2022).
Wakai, K., Azuma, K., Iwamura, C., Maimaiti, M., Mikami, K., Yoneda, K., Sakamoto, S., Ikehara, S., Yamaguchi, T., Hirahara, K., Ichikawa, T., Nakayama, T., and Ikehara, Y.: The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice. Sci. Rep. 12(1):9046 (2022).
Shinoda, K.*, Choe, A.*, Hirahara, K.,* Kiuchi, M., Kokubo, K., Ichikawa, T., Hoki, J. S., Suzuki, A. S., Bose, N., Appleton, J. A., Aroian, R. V., Schroeder, F. C., Sternberg, P. W., and Nakayama, T.: Nematode ascarosides attenuate mammalian type 2 inflammatory responses. (*These authors contributed equally to this work) Proc. Natl. Acad. Sci. USA 119(9):e2108686119 (2022).
【2021年】
Kiuchi, M., Onodera, A., Kokubo, K., Ichikawa, T., Morimoto, Y., Kawakami, E., Takayama, N., Eto, K., Koseki, H., Hirahara, K., and Nakayama, T.: The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. J. Exp. Med. 218(4):e20201690 (2021).
Takasato, Y., Kurashima, Y., Kiuchi, M., Hirahara, K., Murasaki, S., Arai, F., Izawa, K., Kaitai, A., Shimada, K., Saito, Y., Toyoshima, S., Nakamura, M., Fujisawa, K., Okayama, Y., Kunisawa, J., Kubo, M., Takemura, N., Uematsu, S., Akira, S., Kitaura, J., Takahashi, T., Nakayama, T., and Kiyono, H.: Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy. Mucosal Immunol. 14(3):640-651 (2021).
Nakayama, T., Hirahara, K., Kimura, M., Iwamura, C., Kiuchi, M., Kokubo, K., Onodera, A., Hashimoto, K., and Motohashi, S.: CD4+ T cells in inflammatory diseases: Pathogenic T-helper cells and the CD69-Myl9 system. Int. Immunol. 33(12):699-704 (2021).
Hirahara, K., Kokubo, K., Aoki, A., Kiuchi, M., and Nakayama T.: The role of CD4+ resident memory T cells in local immunity in the mucosal tissue - Protection versus Pathology. Front. Immunol. 12:616309 (2021).
Hirahara, K., Aoki, A., and Nakayama, T.: Pathogenic helper T (Tpath) cells. Allergol. Int. 70(2):169-173 (2021).
Hirahara, K., Aoki, A., Kiuchi, M., and Nakayama, T.: Memory-type pathogenic Th2 cells and ILC2s in type 2 allergic inflammation. J. Allergy Clin. Immunol. 147(6):2063-2066 (2021).
Aoki, A.*, Hirahara, K.*, Kiuchi, M., and Nakayama, T.: Eosinophils: Cells known for 140 years with broad and new function. (*These authors are contributed equally to this work) Allergol. Int. 70(1):3-8 (2021).
【2020年】
Sciumè, G., Mikami, Y., Jankovic, D., Nagashima, H., Villarino, A. V., Morrison, T., Signorella, S., Yao, C., Sun, H. W., Brooks, S. R., Fang, D., Sartorelli, V., Nakayamada, S., Hirahara, K., Zitti, B., Davis, F. P., Kanno, Y., O'Shea, J. J., and Shih, H. Y.: Rapid enhancer remodeling and transcription factor repurposing enable high magnitude gene induction upon acute activation of NK cells. Immunity 53(4):745-758.e4 (2020).
Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Toyoda, T., Okada, R., Hino, M., Koyama-Nasu, R., Kiuchi, M., Hirahara, K., Kimura, M. Y., Nakayama, T., Shimojo, N., and Motohashi, S.: Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner. Cancer Sci. 111(7):2223-2233 (2020).
Suzuki, A. S., Yagi, R., Kimura, M. Y., Iwamura, C., Shinoda, K., Onodera, A., Hirahara, K., Tumes, D. J., Koyama-Nasu, R., Iismaa, S. E., Graham, R. M., Motohashi, S., and Nakayama, T.: Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front. Immunol. 11:1536 (2020).
Göschl, L., Preglej, T., Boucheron, N., Saferding, V., Müller, L., Platzer, A., Hirahara, K., Han-Yu, S., Backlund, J., Matthias, P., Niederreiter, B., Hladik, A., Kugler, M., Gualdoni, G., Scheinecker, C., Knapp, S., Seiser, C., Holmdahl, R., Tillmann, K., Plasenzotti, R., Podesser, B., Aletaha, D., Smolen Karonitsch, T. J., Steiner, G., Ellmeier, W., and Bonelli, M.: Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis. J. Autoimmun. 108:102379 (2020).
【2019年】
Ichikawa, T.*, Hirahara, K.*, Kokubo, K.*, Kiuchi, M., Aoki, A., Morimoto, Y., Kumagai, J., Onodera, A., Mato, N., Tumes, D. J., Goto, Y., Hagiwara, K., Inagaki, Y., Sparwasser, T., Tobe, K., and Nakayama, T.: CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells. (*These authors contributed equally to this work) Nat. Immunol. 20(11):1469-1480 (2019).
Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Yip, K. H., Pant, H., Kokubo, K., Kiuchi, M., Aoki, A., Obata-Ninomiya, K., Tokoyoda, K., Endo, Y., Kimura, M. Y., and Nakayama, T.: Ezh2 controls development of natural killer T cells, which cause spontaneous asthma-like pathology. J. Allergy Clin. Immunol. 144(2):549-560.e10 (2019).
Wada, T.*, Hirahara, K.*, Aoki, A., Morimoto, Y., Kiuchi, M., Kumagai, J., Okano, M., Kokubo, K., Kato, M., Fukano, C., Ohashi-Doi, K., and Nakayama, T.: An optimized protocol for the analysis of house dust mites (Dermatophagoides farinae)-induced neutrophil-dominant airway inflammation. (*These authors contributed equally to this work) J. Immunol. Methods 465:53-60 (2019).
Hirahara, K., and Nakayama, T.: Induction and regulation of mucosal memory T cell response. MUCOSAL VACCINES Second Edition ed. Hiroshi Kiyono, David W. Pascual, CA: Academic Press Inc., 133-140 (2019).
Hirahara, K.*, Aoki, A.*, Morimoto, Y., Kiuchi, M., Okano, M., and Nakayama, T.: The immunopathology of lung fibrosis: Amphiregulin-producing pathogenic memory T helper-2 cells control the airway fibrotic responses by inducing eosinophils to secrete osteopontin. (*These authors contributed equally to this work) Semin. Immunopathol. 41(3):339-348 (2019).
Hirahara, K.: Pathogenicity of acquired immunity in human diseases. Semin. Immunopathol. 41(3):279-281 (2019).
Hirahara, K., Shinoda, K., Morimoto, Y., Kiuchi, M., Aoki, A., Kumagai, J., Kokubo, K., and Nakayama, T.: Immune cell-epithelial/mesenchymal interaction contributing to allergic airway inflammation associated pathology. Front. Immunol. 10:570 (2019).
【2018年】
Yamamoto, T., Endo, Y., Onodera, A., Hirahara, K., Asou, H. K., Nakajima, T., Kanno, T., Ouchi, Y., Uematsu, S., Nishimasu, H., Nureki, O., Tumes, D. J., Shimojo, N., and Nakayama, T.: DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat. Commun. 9(1):4231 (2018).
Obata-Ninomiya, K., Ishiwata, K., Nakano, H., Endo, Y., Ichikawa, T., Onodera, A., Hirahara, K., Okamoto, Y., Kanuka, H., and Nakayama, T.: CXCR6+ST2+ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 115(42):E9849-E9858 (2018).
Morimoto, Y.,* Hirahara, K.,* Kiuchi, M., Wada, T., Ichikawa, T., Kanno, T., Okano, M., Kokubo, K., Onodera, A., Sakurai, D., Okamoto, Y., and Nakayama, T.: Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. (*These authors contributed equally to this work) Immunity 49(1):134-150.e6 (2018).
Iinuma, T., Okamoto, Y., Morimoto, Y., Arai, T., Sakurai, T., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy 73(2):479-489 (2018).
Goschl, L., Preglej, T., Hamminger, P., Bonelli, M., Andersen, L., Boucherron, N., Gulich, A. F., Muller, L., Saferding, V., Mufazolov, I. A., Hirahara, K., Seiser, C., Matthias, P., Penz, T., Schuster, M., Bock, C., Waisman, A., Steiner, G., and Ellmeier, W.: A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis. J. Autoimmun. 86:51-61 (2018).
Hirahara, K., Mato, N., Hagiwara, K., and Nakayama, T.: The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+CD4+ T cells. J. Leukoc. Biol. 104(5):895-901 (2018).
Hirahara, K., Shinoda, K., Endo, Y., Ichikawa, T., and Nakayama, T.: Maintenance of memory-type pathogenic Th2 cells in the pathophysiology of chronic airway inflammation. Inflamm. Regen. 38:10 (2018).
Ito, T., Hirahara, K., Onodera, A., Koyama-Nasu, R., Yano, I., and Nakayama, T.: Anti-tumor immunity via the superoxide-eosinophil axis induced by lipophilic component of Mycobacterium lipomannan. Int. Immunol. 29(9):411-421 (2017).
Onodera, A., Kiuchi, M., Kokubo, K., Kato, M., Ogino, T., Horiuchi, S., Kanai, U., Hirahara, K., and Nakayama, T.: Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. J. Immunol. 199(3):1153-1162 (2017).
Mato, N.*, Hirahara, K.*, Ichikawa, T., Kumagai, J., Nakayama, M., Yamasawa, H., Bando, M., Hagiwara, K., Sugiyama, Y., and Nakayama, T.: Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. (*These authors contributed equally to this work) Sci. Rep. 7(1):6805 (2017).
Iwata, S., Mikami, Y., Sun, H. W., Brooks, R. S., Jankovic, D., Hirahara, K., Onodera, A., Shih, H. Y., Kawabe, T., Jiang, K., Nakayama, T., Sher, A., O'Shea, J. J., Davis, F. P., and Kanno, Y.: The transcription factor T-bet limits amplification of type l IFN transcriptome and circuitry in T helper 1 cells. Immunity 46(6):983-991.e4 (2017).
Brück, J., Holstein, J., Glocova, I., Seidel, U., Geisel, J., Kanno, T., Kumagai, J., Mato, N., Sudowe, S., Widmaier, K., Sinnberg, T., Yazdi, A. S., Eberle, F. C., Hirahara, K., Nakayama, T., Röcken, M., and Ghoreschi, K.: Nutritional control of IL-23/Th17-mediated autoimmune disease through HO-1/STAT3 activation. Sci. Rep. 14(7):44482 (2017).
Tumes, D. J., Papadopoulos, M., Endo, Y., Onodera, A., Hirahara, K., and Nakayama, T.: Epigenetic regulation of T helper cell differentiation, memory and plasticity in allergic asthma. Immunol. Rev. 278(1):8-19 (2017).
Shinoda, K., Hirahara, K., and Nakayama, T.: Maintenance of pathogenic Th2 cells in allergic disorders. Allergol. Int. 66(3):369-376 (2017).
Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., and Okamoto, Y.: Th2 cells in health and disease. Annu. Rev. Immunol. 26(35):53-84 (2017).
Hayashizaki, K., Kimura, M. Y., Tokoyoda, K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D. J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y., and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci. Immunol. 1(3):eaaf9154 (2016).
Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T.: Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA 113(20):E2842-E2851 (2016).
Jain, R., Chen, Y., Kanno, Y., Joyce-Shaikh, B., Vahedi, G., Hirahara, K., Blumenschein, W. M., Sukumar, S., Haines, C. J., Sadekova, S., McClanahan, T. K., McGeachy, M. J., O'Shea, J. J., and Cua, D. J.: Interleukin-23-induced transcription factor Blimp-1 promotes pathogenicity of T helper 17 cells. Immunity 44(1):131-42 (2016).
Bonelli, M., Goschl, L., Bluml, S., Karonitsch, T., Hirahara, K., Ferner, E., Steiner, C. W., Steiner, G., Smolen, J. S., and Scheinecker, C.: Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford) 55(4):710-20 (2016).
Endo, Y., Hirahara, K., Shinoda, K., Iinuma, T., Yamamoto, H., Motohashi, S., Okamoto, Y., and Nakayama, T.: Human and mouse memory-type pathogenic Th2 (Tpath2) cells in airway inflammation. Chronic Inflammation Mechanisms and Regulation ed. Masayuki Miyasaka, Kiyoshi Takatsu, CA: Wien Heidelberg New York Dordrecht London: Springer, 401-415 (2016).
Hirahara, K., Schwartz, D., Gadina, M., Kanno, Y., and O'Shea, J. J.: Targeting cytokine signaling in autoimmunity: back to the future and beyond. Curr. Opin. Immunol. 43:89-97 (2016).>
Nakayama, T., Endo, Y., Shinoda, K., and Hirahara, K.: Pathogenic memory Th2 cells in airway inflammation. Cornea 35:S8 (2016).
Hirahara, K., and Nakayama, T.: CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int. Immunol. 28(4):163-171 (2016).
Eberle, F. C., Bruck, J., Holstein, J., Hirahara, K., and Ghoreschi, K.: Recent advances in understanding psoriasis. F1000Res. 5:F1000 Faculty Rev-770 (2016).
Onodera, A., Tumes, D. J., Watanabe, Y., Hirahara, K., Kaneda, A., Sugiyama, F., Suzuki,. Y, and Nakayama, T.: Spatial interplay between polycomb and trithorax complexes controls transcriptional activity in T lymphocytes. Mol. Cell. Biol. 35 (22):3841-53 (2015).
Endo, Y., Asou, H. K., Matsugae, N., Hirahara, K., Shinoda, K., Tumes, D. J., Tokuyama, H., Yokote, K., and Nakayama, T.: Obesity drives Th17 cell differentiation by inducing the lipid metabolic kinase, ACC1. Cell Rep. 12(6):1042-1055 (2015).
Yang, X. P., Jiang, K., Hirahara, K., Vahedi, G., Afzali, B., Sciume, G., Boneli, M., Sun, H. W., Jankovic, D., Kanno, Y., Sartorelli, V., O'Shea, J. J., and Laurence, A.: EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion. Sci. Rep. 5:10643 (2015).
Hirahara, K., Onodera, A., Villario, A. V., Bonelli, M., Sciumè, G., Laurence, A., Sun, H. W., Brooks, R. S., Vahedi, G.,Shih, H. Y., Gtierrez-Cruz, G., Iwata, S., Suzuki, R., Mikami, Y., Okamoto, Y., Nakayama, T., Holland, S., Hunter, C. A., Kanno, Y., and O'Shea, J. J.: Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity 42(5):877-889 (2015).
Iinuma, T., Okamoto, Y., Yamamoto, H., Inamine-Sasaki, A., Ohki, Y., Sakurai, T., Funakoshi, U., Yonekura, S., Sakurai, D., Hirahara, K., and Nakayama, T.: IL-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis. Ann. Allergy Asthma Immunol. 114(4):289-298 (2015).
Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K., Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.: The Interleukin-33-p38 kinase axis confers memory T helper-2 cell pathogenicity in the airway. Immunity 42(2):294-308 (2015).
Watanabe, Y., Onodera, A., Kanai, U., Ichikawa, T., Obata-Ninomiya, K., Wada, T., Kiuchi, M., Iwamura, C., Tumes, D. J., Shinoda, K., Yagi, R., Motohashi, S., Hirahara, K., and Nakayama, T.: Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc. Natl. Acad. Sci. USA 111(35):12829-12834 (2014).
Steward-Tharp, S. M., Laurence, A., Kanno, Y., Kotlyar, A., Villarino, A. V., Sciume, G., Kuchen, S., Resch, W., Wohlfert, E. A., Jiang, K., Hirahara, K., Vahedi, G., Sun, H. W., Feigenbaum, L., Milner, J. D., Holland, S. M., Casellas, R., Powrie, F., and O'Shea, J. J.: A mouse model of HIES reveals pro-and anti-inflammatory functions of STAT3. Blood 123(19):2978-2987 (2014).
Nakayamada, S., Poholek, A. C., Lu, K. T., Takahashi, H., Kato, M., Iwata, S., Hirahara, K., Cannons, J. L., Schwartzberg, P. L., Vahedi, G., Sun, H. W., Kanno, Y., and O'Shea, J. J.: Type I IFN Induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J. Immunol. 192(5):2156-2166 (2014).
Shih, H. Y., Sciumè, G., Poholek, A., Vahedi, G., Hirahara, K., Villarino, A. V., Bonelli, M., Bosselut, R., Kanno, Y., Muljo, S. A., and O'Shea, J. J.: Transcriptional and epigenetic networks of helper T and innate lymphoid cells. Immunol. Rev. 261(1):23-49 (2014).
Bonelli, M., Shih, H. Y., Hirahara, K., Singelton, K., Laurence, A., Poholek, A., Hand, T., Mikami, Y., Vahedi, G., Kanno, Y., and O'Shea, J. J.: Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr. Top. Microbiol. Immunol. 381:279-326 (2014).
Endo, Y., Hirahara, K., Yagi, R., Tumes, D. J., and Nakayama, T.: Pathogenic memory type Th2 cells in allergic inflammation. Trends Immunol. 35(2):69-78 (2014).
Hosokawa, H., Tanaka, T., Kato, M., Shinoda, K., Tohyama, H., Hanazawa, A., Tamaki, Y., Hirahara, K., Yagi, R., Sakikawa, I., Morita, A., Nagira, M., Poyurovsky, M. V., Suzuki, Y., Motohashi, S., and Nakayama, T.: Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. Proc. Natl. Acad. Sci. USA 110(46):18626-18631 (2013).
Roychoudhuri, R.*, Hirahara, K.*, Mousavi, K.*, Clever, D., Klebanoff, C. A., Bonelli, M., Sciume, G., Zare, H., Vahedi, G., Dema, B., Yu, Z., Liu, H., Takahashi, H., Rao, M., Muranski, P., Crompton, J. G., Punkosdy, G., Bedognetti, D., Wang, E., Hoffmann, V., Rivera, J., Marincola, F. M., Nakamura, A., Sartorelli, V., Kanno, Y., Gattinoni, L., Muto, A., Igarashi, K., O'Shea, J. J., and Restifo, N. P.: BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis. (*These authors are contributed equally to this work) Nature 498(7455):506-510 (2013).
Hirahara, K., Poholek, A., Vahedi, G., Laurence, A., Kanno, Y., Milner, J. D., and O'Shea, J. J.: Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J. Allergy Clin. Immunol. 131(5):1276-1287 (2013).
Vahedi, G., Poholek A. C., Hand, T. W., Laurence, A., Kanno, Y., O'Shea, J. J., and Hirahara, K.: Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol. Rev. 252(1):24-40 (2013).
Sciumè, G., Hirahara, K., Takahashi, H., Laurence, A., Villarino, A. V., Singleton, K. L., Spencer, S. P., Wilhelm, C., Poholek, A. C., Vahedi, G., Kanno, Y., Belkaid, Y., and O'Shea, J. J.: Distinct requirements for T-bet in gut innate lymphoid cells. J. Exp. Med. 209(13):2331-2338 (2012).
Hirahara, K.*, Ghoreschi, K.*, Yang, X. P., Takahashi, H., Laurence, A., Vahedi, G., Sciumè, G., Hall, A. O., Dupont, C. D., Francisco, L. M., Chen, Q., Tanaka, M., Kanno, Y., Sun, H. W., Sharpe, A. H., Hunter, C. A., and O'Shea, J. J.: Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. (*These authors contributed equally to this work) Immunity 36(6):1017-1030 (2012).
Takahashi, H., Kanno, T., Nakayamada, S., Hirahara, K., Sciumè, G., Muljo, S. A., Kuchen, S., Casellas, R., Wei, L., Kanno, Y., and O'Shea, J. J.: TGF-𝛃 and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nat. Immunol. 13(6):587-595 (2012).
Villarino, A., Yang, X. P., Hirahara, K., Kanno, Y., O'Shea, J. J., and Laurence, A.: Function of JAKs and STATs in lymphocyte: bench to bedside. Jak-Stat Signaling: From Basics to Disease ed. Thomas Decker, CA: Wien Heidelberg New York Dordrecht London: Springer, 205-237 (2012).
Laurence, A., Ghoreschi, K., Hirahara, K., Yang, X. P., and O'Shea, J. J.: Therapeutic inhibition of the Janus kinases. Inflammation and Regeneration 32(1):16-22 (2012).
Kanno, Y., Vahedi, G., Hirahara, K., Singleton, K., and O'Shea, J. J.: Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30:707-731 (2012).
Yang, X. P., Ghoreschi, K., Steward-Tharp, S. M., Rodriguez-Canales, J., Zhu, J., Grainger, J. R., Hirahara, K., Sun, H. W., Wei, L., Vahedi, G., Kanno, Y., O'Shea, J. J., and Laurence, A.: Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12(3):247-254 (2011).
Hirahara, K., Vahedi, G., Ghoreschi, K., Yang, X. P., Nakayamada, S., Kanno, Y., O'Shes, J. J., and Laurence, A.: Helper T-cell differentiation and plasticity: insights from epigenetics. Immunology 134(3):235-245 (2011).
Ghoreschi, K., Laurence, A., Yang, X. P., Hirahara, K., and O'Shea, J. J.: T helper 17 cell heterogeneity and pathogenicity in autoimmune disease. Trends Immunol. 32(9):395-401 (2011).
Hirahara, K., Ghoreschi, K., Laurence, A., Yang, X. P., Kanno, Y., and O'Shea, J. J.: Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev. 21(6):425-434 (2010).
Hirahara, K., Yamashita, M., Iwamura, C., Shinoda, K., Hasegawa, A., Yoshizawa, H., Koseki, H., Gejyo, F., and Nakayama, T.: Repressor of GATA regulates TH2-driven allergic airway inflammation and airway hyperresponsiveness. J. Allergy Clin. Immunol. 122(3):512-520 (2008).
Yamashita, M., Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.: Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J. Exp. Med. 205(5):1109-1120 (2008).
Yamashita, M., Hirahara, K., Shinnakasu, R., Hosokawa, H., Norikane, S., Kimura, M. Y., Hasegawa, A., and Nakayama, T.: Crucial role of MLL for the maintenance of memory T helper type 2 cell responses. Immunity 24(5):611-622 (2006).
Nigo, Y. I., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., and Nakayama, T.: Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103(7):2286-2291 (2006).