業績  

小室 一成

2012 | 2011 | 2010 | 2009 | 2008 |
| 原著論文| 総説/著書| 国際会議| 国内会議| 特許| 受賞 |

原著論文

Yasuda N‚ Akazawa H‚ Qin Y‚ Zou Y‚ Komuro I.   A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.
Naunyn Schmiedebergs Arch Pharmacol.  2008;  377   (4-6):   393-399


Shiina Y‚ Funabashi N‚ Fujikawa A‚ Lee K‚ Sekine T‚ Uehara M‚ Mikami Y‚ Tanabe N‚ Kuriyama T‚ Komuro I.   Quantitative evaluation of chronic pulmonary thromboemboli by multislice CT compared with pulsed Tissue Doppler Imaging and its relationship with brain natriuretic peptide.
Int J Cardiol.  2008;  130   (3):   505-512


Nakamura K‚ Funabashi N‚ Miyauchi H‚ Aminaka M‚ Uehara M‚ Ueda M‚ Murayama T‚ Hori Y‚ Nakayama T‚ Daimon M‚ Kuroda N‚ Kobayashi Y‚ Komuro I.   Hemangioma located just above the left main coronary artery‚ in a subject who had cardiac arrest due to ventricular fibrillation‚ led to a diagnosis of Brugada syndrome.
Int J Cardiol.  2008;  127   (3):   437-441


Utsumi T‚ Ohtsuka M‚ Uchida E‚ Yamaguchi H‚ Nakajima T‚ Akazawa H‚ Takano H‚ Nakaya H‚ Komuro I.   Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis.
Int J Cardiol.  2008;  128   (2):   294-295


Uehara M‚ Funabashi N‚ Mikami Y‚ Shiina Y‚ Nakamura K‚ Komuro I.   Quantitative effect of atorvastatin on size and content of non-calcified plaques of coronary arteries 1 year after atorvastatin treatment by multislice computed tomography.
Int J Cardiol.  2008;  130   (2):   269-275


Nakamura K‚ Funabashi N‚ Uehara M‚ Suzuki K‚ Terao M‚ Okubo K‚ Mita Y‚ Maeda F‚ Komuro I.   Quantitative 4-dimensional volumetric analysis of left ventricle in ischemic heart disease by 64-slice computed tomography: a comparative study with invasive left ventriculogram.
Int J Cardiol.  2008;  129   (1):   42-52


Shiina Y‚ Funabashi N‚ Lee K‚ Toyoda T‚ Sekine T‚ Honjo S‚ Hasegawa R‚ Kawata T‚ Wakatsuki Y‚ Hayashi S‚ Murakami S‚ Koike K‚ Daimon M‚ Komuro I.   Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography.
Int J Cardiol.  2008;  129   (2):   193-197


Mizuno N‚ Funabashi N‚ Nakamura K‚ Uehara M‚ Suzuki K‚ Terao M‚ Okubo K‚ Mita Y‚ Maeda F‚ Komuro I.   Utility of multislice computed tomography with a 64-data acquisition system for four-dimensional volumetric analysis using a pulsating phantom and considering pulsation rate and reconstruction methods.
Int J Cardiol.  2008;  130   (3):   477-480


Toko H‚ Minamino T‚ Komuro I   Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy.
Trends Cardiovasc Med.  2008;  18   (3):   88-93


Nagao K‚ Taniyama Y‚ Kietzmann T‚ Doi T‚ Komuro I‚ Morishita R.   HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus.
J Biol Chem.  2008;  283   (17):   11841-11849


Ohkubo K‚ Kobayashi Y‚ Komuro I.   Do not forget vasospastic angina in patients with chest pain at rest and no significant coronary stenosis with multidetector computed tomography.
Am J Cardiol.  2008;  101   (10):   1519-


Origasa H‚ Goto S‚ Uchiyama S‚ Shimada K‚ Ikeda Y; J-TRACE Investigators.   The Japan Thrombosis Registry for Atrial Fibrillation‚ Coronary or Cerebrovascular Events (J-TRACE): a nation-wide‚ prospective large cohort study; the study design.
Circ J.  2008;  72   (6):   991-997


Kami D‚ Shiojima I‚ Makino H‚ Matsumoto K‚ Takahashi Y‚ Ishii R‚ Naito AT‚ Toyoda M‚ Saito H‚ Watanabe M‚ Komuro I‚ Umezawa A.   Gremlin enhances the determined path to cardiomyogenesis.
PLoS ONE.  2008;  11   (3):   e2407-


Lai ZF‚ Chen YZ‚ Feng LP‚ Meng XM‚ Ding JF‚ Wang LY‚ Ye J‚ Li P‚ Cheng XS‚ Kitamoto Y‚ Monzen K‚ Komuro I‚ Sakaguchi N‚ Kim-Mitsuyama S.   Overexpression of TNNI3K‚ a cardiac-specific MAP kinase‚ promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury.
Am J Physiol Heart Circ Physiol.  2008;  295   (2):   H708-716


Nishi J‚ Minamino T‚ Miyauchi H‚ Nojima A‚ Tateno K‚ Okada S‚ Orimo M‚ Moriya J‚ Fong GH‚ Sunagawa K‚ Shibuya M‚ Komuro I.   Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt.
Circ Res.  2008;  103   (3):   261-268


Narumi H‚ Yoshida K‚ Hashimoto N‚ Umehara I‚ Funabashi N‚ Yoshida S‚ Komuro I.   Increased subcutaneous fat accumulation has a protective role against subclinical atherosclerosis in asymptomatic subjects undergoing general health screening.
Int J Cardiol.  2008;  135   (2):   150-155


Fukushima K‚ Kobayashi Y‚ Kitahara H‚ Iwata Y‚ Nakayama T‚ Kuroda N‚ Ooyama M‚ Nomura F‚ Komuro I.   Effect of 150-mg vs 300-mg loading doses of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement.
Circ J.  2008;  72   (8):   1282-1284


Odaka K‚ Uehara T‚ Arano Y‚ Adachi S‚ Tadokoro H‚ Yoshida K‚ Hasegawa H‚ Imanaka-Yoshida K‚ Yoshida T‚ Hiroe M‚ Irie T‚ Tanada S‚ Komuro I.   Noninvasive detection of cardiac repair after acute myocardial infarction in rats by 111 In Fab fragment of monoclonal antibody specific for tenascin-C.
Int Heart J.  2008;  49   (4):   481-492


Kadohira T‚ Kobayashi Y‚ Asano T‚ Uehara M‚ Funabashi N‚ Nakayama T‚ Kuroda N‚ Komuro I.   Fatal very late stent thrombosis in a young diabetic patient with severely diffuse coronary atherosclerosis.
Int Heart J.  2008;  49   (4):   507-513


Ajima R‚ Akazawa H‚ Kodama M‚ Takeshita F‚ Otsuka A‚ Kohno T‚ Komuro I‚ Ochiya T‚ Yokota J.   Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
Genes Cells.  2008;  13   (10):   987-999


Asano T‚ Kobayashi Y‚ Fukushima K‚ Iwata Y‚ Kitahara H‚ Ishio N‚ Kuroda N‚ Komuro I.   Safety and efficacy of low-dose clopidogrel in Japanese patients undergoing coronary stenting: preliminary 30-day clinical outcome.
Circ J.  2008;  72   (10):   1707-1708


Minamino T‚ Komuro I.   Vascular aging: insights from studies on cellular senescence‚ stem cell aging‚ and progeroid syndromes.
Nat Clin Pract Cardiovasc Med.  2008;  5   (10):   637-648


Nakamura K‚ Funabashi N‚ Uehara M‚ Suzuki K‚ Terao M‚ Okubo K‚ Mita Y‚ Maeda F‚ Komuro I.   Impairment factors for evaluating the patency of drug-eluting stents and bare metal stents in coronary arteries by 64-slice computed tomography versus conventional coronary angiography.
Int J Cardiol.  2008;  130   (3):   349-356


Kitahara H‚ Kobayashi Y‚ Yamaguchi M‚ Ohkubo K‚ Nakayama T‚ Kuroda N‚ Komuro I.   Damage to polymer of paclitaxel-eluting stent.
Circ J.  2008;  72   (11):   1907-1908


Zhu W‚ Shiojima I‚ Ito Y‚ Li Z‚ Ikeda H‚ Yoshida M‚ Naito AT‚ Nishi J‚ Ueno H‚ Umezawa A‚ Minamino T‚ Nagai T‚ Kikuchi A‚ Asashima M‚ Komuro I.   IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis.
Nature.  2008;  454   (7202):   345-349


Monzen K‚ Ito Y‚ Naito AT‚ Kasai H‚ Hiroi Y‚ Hayashi D‚ Shiojima I‚ Yamazaki T‚ Miyazono K‚ Asashima M‚ Nagai R‚ Komuro I.   A crucial role of a high mobility group protein HMGA2 in cardiogenesis
Nat Cell Biol  2008;  10     567-574


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総説/著書

Tateno K‚ Minamino T‚ Moriya J‚ Katada A‚ Yokoyama M‚ Miura K‚ Komuro I.   Cell Therapy for Cardiovascular Diseases   Annals of Vascular Diseases  2008;  1   (2):   66-79


Toko H‚ Minamino T‚ Komuro I.   Role of heat shock transcriptional factor 1 and heat shock proteins in cardiac hypertrophy.   Trends Cardiovasc Med.  2008;  18   (3):   88-93


舘野馨‚ 南野徹‚ 小室一成   下肢虚血に対する血管再生治療の機序に関する問題点   脈管学(日本脈管学会機関誌)  2008;  48   (5):   431-435


東口治弘   Ativation of CaMKIId plays an important for mutated cardiac a-actin induced dilated cardiomyopathy.    分子心血管病  2008;  9     401-402


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国際会議

Komuro I. Myocardial and Vascular Rebirth 
Stems of the Heart 2008-9-11 Boston/U.S.A.


Komuro I. A Novel Cardiomyocyte Diffrentiation 
Hearts of Japan 2008-8-1 San Diego/U.S.A.


Ito K‚ Akazawa H‚ Tamagawa M‚ Ogawa W‚ Kasuga M‚ Nakaya H‚ Komuro I. PDK-1 is required for b-adrenergic response and cell survival in the hearts. 
5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences 2008-7-28 Keystone/U.S.A.


Yoshida M‚ Shiojima I‚ Komuro I. Pitavastatin attenuates doxorubicin-induced cardiotoxicity through anti-oxidant effect 
5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences 2008-7-28 Keystone/U.S.A.


Toko H‚ Kayama Y‚ Takahashi H‚ Minamino T‚ Komuro I. Activation of CaMKIIdelta is Critically Involved in Mutated Cardiac Alpha-Actin Induced Dilated Cardiomyopathy. 
5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences 2008-7-28 Keystone/U.S.A.


Uchiyama R‚ Takano H‚ Ueda K‚ Niitsuma Y‚ Hasegawa H‚ Komuro I. Erythropoietin promotes angiogenesis and prevents heart failure after myocardial infarction 
5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences 2008-7-28 Keystone/U.S.A.


Tateno K‚ Moriya K‚ Miura K‚ Minamino T‚ Komuro I. In-situ Activation of Constituent Platelets Enhance the Therapeutic Capacity of Peripheral Blood Mononuclear Cell Implantation 
5th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences 2008-7-28 Keystone/U.S.A.


Moriya J‚ Minamino T‚ Komuro I. A pathological role of Semaphorin3E/PlexinD1 in impaired angiogenesis of diabetes. 
The 6th Korea-Japan Joint Symposium on Vascular Biology 2008-12-3 Kanazawa/Japan


Moriya J‚ Minamino T‚ Tateno K‚ Orimo M‚ Miyauchi H‚ Okada S‚ Shimizu I‚ Nojima A‚ Yokoyama M‚ Komuro I. Semaphorin3E is a Novel Angiogenic Regulator. 
American heart association Scientific Sessions 2008 2008-11-8 New Orleans‚ Louisiana/U.S.A.


Ito K‚ Akazawa H‚ Tamagawa M‚ Ogawa W‚ Kasuga M‚ Nakaya H‚ Komuro I PDK1 plays crucial roles in beta-adrenergic response and cell survival in the heart. 
American heart association Scientific Sessions 2008 2008-11-8 New Orleans‚ Louisiana/U.S.A.


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国内会議

伊藤薫‚ 赤澤宏‚ 玉川正次‚ 康田 典鷹‚ 坂本陽子‚ 廖千恵‚ 小川渉‚ 春日雅人‚ 中谷晴昭‚ 小室一成 PDK1は心筋でのβ受容体反応と細胞生存に必須である 
第12回Molecular Cardiovascular Conference 2008-9-5 小樽


Yoshida M‚ Shiojima I‚ Ikeda H‚ Komuro I. Pitavastatin attenuates doxorubicin-induced cardiotoxicity through the inhibition of oxidative stress-DNA damage-ATM-p53 pathway. 
第12回Molecular Cardiovascular Conference 2008-9-5 小樽


小室一成 心肥大はなぜ恐いか!? 癌より恐い心不全 
日本血管生物医学会 プレスセミナー 2008-9-24 東京


舘野馨‚ 森谷純治‚ 南野徹‚ 小室一成 末梢血単核球細胞を用いた血管再生治療 
第8回心血管再生先端治療フォーラム 2008-7-5 東京


小室一成 心不全モデルマウスから考える分子メカニズム 
第21回東海心筋代謝研究会 2008-7-4 名古屋


小室一成 心不全発症の分子機序 
第45回日本臨床分子医学会学術集会 2008-7-24 大阪


小室一成 心肥大から心不全発症の分子機序 
第27回高血圧シンポジウム-基礎から臨床まで- 2008-7-12 大阪


森谷純治‚ 南野徹‚ 舘野馨‚ 小室一成 血管新生治療における新たな標的分子:Semaphorin3EとPlexinD1 
第40回日本動脈硬化学会総会・学術集会 2008-7-10 つくば


小室一成 高血圧治療における血管保護の重要性 
第50回日本老年医学会学術集会 2008-6-19 千葉


森谷純治‚ 南野徹‚ 小室一成 Semaphorin3Eはp53によって制御される新たな血管調節分子である 
第12回日本心血管内分泌代謝学会学術総会 2008-11-28 熊本


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特許

2008-286293 虚血性心疾患系疾患の治療剤 
森谷純治‚ 南野徹‚ 小室一成 日本
2008-11-7


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受賞

2008-12-5
 2008 Joint Meeting of Korea-Japan Joint Symposium on Vascular Biology and Japan Vascular Biology and Medicine Organization Young Investigator Award Joint Meeting of Korea-Japan Joint Symposium on Vascular Biology and Japan Vascular Biology and Medicine Organization Moriya J

2008-11-29
 第12回日本心血管内分泌代謝学会 若手研究奨励賞 日本心血管内分泌代謝学会 森谷 純治

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