業績
中山 俊憲| 2012 | 2011 | 2010 | 2009 | 2008 | 2006 |
| 原著論文| 総説/著書| 国際会議| 国内会議| マスコミ掲載/その他 |
原著論文
Iwamura C‚ Shinoda K‚ Endo Y‚ Watanabe Y‚ Tumes D.J‚ Motohashi S‚ Kawahara K‚ Kinjo Y‚ Nakayama T. Regulation od memory CD4 T-cell pool size and function by natural killer T cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America. 2012; 109 (42): 16992-16997
Lavial‚ F.‚ Bessonnard‚ S.‚ Ohnishi‚ Y.‚ Tsumura‚ A.‚ Chandrashekran‚ A.‚ Fenwick‚ M.‚ Tomaz‚ R. A.‚ Hosokawa‚ H.‚ Nakayama‚ T.‚ Chambers‚ I.‚ Hiiragi‚ T.‚ Chazaud‚ C.‚ and Azuara‚ V. Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.
Genes Dev. 2012; In press
Nagato‚ K.‚ Motohashi‚ S.‚ Ishibashi‚ F.‚ Okita‚ K.‚ Yamasaki‚ K.‚ Moriya‚ Y.‚ Hoshino‚ H.‚ Yoshida‚ S.‚ Hanaoka‚ H.‚ Fuji‚ S.‚ Taniguchi‚ M.‚ Yoshino‚ I.‚ and Nakayama‚ T. Accumulation of activated invariant natural killer T cells in the tumor microenvironment after α-Galactosylceramide-pulsed antigen presenting cells.
J. Clin. Immunol. 2012; In press
Watanabe‚ M.‚ Nakajima‚ S.‚ Ohnuki‚ K.‚ Ogawa‚ S.‚ Yamashita‚ M.‚ Nakayama‚ T.‚ Murakami‚ Y.‚ Tanabe‚ K.‚ and Abe‚ R. The transcription factor AP-1 is involved in ICOS gene expression downstream of TCR/CD28 signaling and cytokine receptor signaling.
Eur. J. Immunol. 2012; In press
Radulovic‚ K.‚ Manta‚ C.‚ Rossini‚ V.‚ Holzmann‚ K.‚ Kestler‚ H. A.‚ Wegenka‚ U. M.‚ Nakayama‚ T.‚ and Niess‚ J. H. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
J Immunol. 2012; 188 (4): 2001-2013
Shinoda‚ K.‚ Tokoyoda‚ K.‚ Hanazawa‚ A.‚ Hayashizaki‚ K.‚ Zehentmeier‚ S.‚ Hosokawa‚ H.‚ Iwamura‚ C.‚ Koseki‚ H.‚ Tumes‚ J. D.‚ Radbruch‚ A.‚ and Nakayama‚ T. Type II membrane protein CD69 regulates the formation of resting T-helper memory.
Proc Natl Acad Sci U S A. 2012; 109 (19): 7409-7414
Ishizaki‚ S.‚ Kasuya‚ Y.‚ Kuroda‚ F.‚ Tanaka‚ K.‚ Tsuyusaki‚ J.‚ Yamauchi‚ K.‚ Matsunaga‚ H.‚ Iwamura‚ C.‚ Nakayama‚ T.‚ and Tatsumi‚ K. Role of CD69 in acute lung injury.
Life Sciences 2012; 90 (17-18): 657-665
Inamine‚ A.‚ Sakurai‚ D.‚ Horiguchi‚ S.‚ Yonekura‚ S.‚ Hanazawa‚ T.‚ Hosokawa‚ H.‚ Matuura-Suzuki‚ A.‚ Nakayama‚ T.‚ and Okamoto‚ Y. Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells.
Clin.Immunol. 2012; 143 (2): 170-179
Miyasaka‚ T.‚ Aoyagi‚ T.‚ Uchiyama‚ B.‚ Oishi‚ K.‚ Nakayama‚ T.‚ Kinjo‚ Y.‚ Miyazaki‚ Y.‚ Kunishima‚ H.‚ Hirakata‚ Y.‚ Kaku‚ M.‚ and Kawakami‚ K. A possible relationship of natural killer T cells with humoral immune response to 23-valent pneumococcal polysaccharide vaccine in clinical settings
Vaccine 2012; 39 (22): 3304-3310
Kuwahara‚ M.‚ Yamashita‚ M.‚ Shinoda‚ K.‚ Tofukuji‚ S.‚ Onodera‚ A.‚ Shinnakasu‚ R.‚ Motohashi‚ S.‚ Hosokawa‚ H.‚ Tumes‚ D.‚ Iwamura‚ C.‚ Lefebvre‚ V.‚ and Nakayama‚ T.: The transcription factor Sox4 is a downstream target of TGF-β signaling and suppresses GATA3-induced TH2 cell differentiation.
Nat. Immunol. 2012; 13 (8): 778-786
Yamashita‚ J.‚ Iwamura‚ C.‚ Mitsumori‚ K.‚ Hosokawa‚ H.‚ Sasaki‚ T.‚ Takahashi‚ M.‚ Tanaka‚ H.‚ Kaneko‚ K.‚ Hanazawa‚ A.‚ Watanabe‚ Y.‚ Shinoda‚ K.‚ Tumes‚ D.‚ Motohashi‚ S.‚ Nakayama‚ T. Murine Schnurri-2 controls Natural Killer cell function and lymphoma development.
Leuk. Lymphoma 2012; 53 (3): 479-486
Satoh‚ M.‚ Andoh‚ Y.‚ Clingan‚ S. C.‚ Ogura‚ H.‚ Fujii‚ S.‚ Nakayama‚ T.‚ Taniguchi‚ M.‚ Hirata‚ N.‚ Ishimori‚ N.‚ Tsutsui‚ H.‚ Onoe‚ K.‚ and Iwabuchi‚ K. Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation‚ steatohepatitis and insulin resistance.
PLoS ONE 2012; 7 (2): e30568-
Kidoya‚ H.‚ Kunii‚ N.‚ Naito‚ H.‚ Muramatsu‚ T.‚ Okamoto‚ Y.‚ Nakayama‚ T.‚ and Takakura‚ N. The apelin/APJ system induces maturation of the tumor vasculature and improves the efficiency of immune therapy.
Oncogene 2012; in press
Aoyagi‚ Y.‚ Kuroda‚ M.‚ Asada‚ S.‚ Tanaka‚ S.‚ Konno‚ S‚. Tanio‚ M.‚ Aso‚ M.‚ Okamoto‚ Y.‚ Nakayama‚ T.‚ Saito‚ Y.‚ Bujo‚ H. Fibrin glue is a candidate scaffold for long-term therapeutic protein expression in spontaneously differentiated adipocytes in vitro.
Exp Cell Res. 2012; 318 (1): 8-15
総説/著書
山下潤二、中山俊憲 アポリポプロテインA-II―自己免疫性肝炎に対する新規治療薬の可能性 医学のあゆみ 2012; 241 (10): 787-788
遠藤裕介、中山俊憲 IL-5産生pathogenicメモリ−Th2細胞による慢性アレルギ−炎症の制御 実験医学別刷 慢性アレルギ−炎症−免疫系の役者たちの新たな姿 2012; 30 (6): 899-904
小野寺淳、中山俊憲 TAT6依存的および非依存的なGata3の発現制御機構―Gata3発現はSTAT6によって誘導され、Menin/TrxG複合体によって維持される― 臨床免疫・アレルギ−科 2012; 57 (3): 330-341
国際会議
Endo. Y.‚ Nakayama.T. Identification of pathogenic memory Th2 cells that produce IL-5 and regulate allergic airway inflammation.
European Academy of Allergy and Clinical Immunology Congress 2012 2012-6-16 Geneva/Switzerlan
Nagato‚ K.‚Motohashi‚ S. Nakayama‚T. Accumulation of activated invariant NKT cells in the tumor microenvironment after α-galactosylceramide-pulsed antigen presenting cells.
Clinical Immunology Society (CIS) Annual Meeting 2012-5-17 Chicago/USA
Nakayama‚ T. Pathogenic memory Th2 cells in airway inflammation.
novo nordisk innovation summit Tokyo 2012 chronic inflammation and autoimmune diseases 2012-4-17 Tokyo/Japan
Shinoda K. CD69 regulates the formation of resting T helper memory
14th International Conference on Lymphocyte Activation and Immune Regulation 2012-3-3 NewPort Beach/USA
Endo Y. Eomesodermin controls IL-5 production in memory Th2 cells through the inhibition of GATA3 activity
14th International Conference on Lymphocyte Activation and Immune Regulation 2012-2-3 Newport Beach/USA
国内会議
國井直樹、本橋新一郎、中山俊憲 "Enhanced function of redirected human T cells expressing LAT thatis resistant to ubiquitylation"
第１６回日本がん免疫学会総会 2012-7-26 札幌市
中山 俊憲 免疫記憶を利用した難治性喘息と肺癌の新規免疫治療法開発のトランスレーショナルリサーチ
BIO tech 2012 第11回国際バイオテクノロジー展/技術会議 2012-4-25 東京
マスコミ掲載/その他
2012-7-2 慢性アレルギーの根治薬期待＝原因細胞抑える仕組み解明ー千葉大 時事通信
ぜんそくやアアトピー性皮膚炎、花粉症などのアレルギー疾患を引きおこす免疫細胞Th2の働きを抑える仕組みを発見。１日付の米科学誌ネイチャー／イミュノロジー電子版に発表した。
2012-7-2 タンパク質がアレルギー抑制、千葉大教授ら解明 読売新聞
人体の細胞内たんぱく質「Ｓｏｘ４」に、アレルギー反応を抑制する機能があることを解明した。
