業績

 

年度一覧

2021　2020

2019　2018　2017　2016　2015　2014　2013　2012　2011　2010  　

2009　2008　2007　2006　2005　2004　2003　2002　2001　2000  

1999　1998　1997　1996　1995　1994  

2021

Li, J., Zhang, Y., Ye, Y., Li, D., Liu, Y., Lee, E., Zhang, M., Dai, X., Zhang, X., Wang, S., Zhang, J., Jia, W., Zen, K., Vidal-Puig, A., Jiang, X., Zhang, C-Y. (2021) Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles 2021 Jan;10(3):e12055.

Wada, M., Yukawa, K., Ogasawara, H., Suzawa, K., Maekawa, T., Yamamoto, Y., Ohta, T., Lee, E., Miki, T. (2021) GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice iScience 24(4):102260.

Hayashi, T., Kubota, T., Inoue, M., Takamoto, I., Aihara, M., Sakurai, Y., Wada, N., Miki, T., Yamauchi, T., Kubota, N., Kadowaki, T. (2021) Lack of brain insulin receptor substrate-1 causes growth retardation, with decreased expression of growth hormone-releasing hormone in the hypothalamus Diabetes 2021 Online ahead of print.

2020

Oduori, O., Murao, N., Shimomura, K., Takahashi, H., Zhang, Q., Dou, H., Sakai, S., Minami, K., Chanclon, B., Guida, C., Kothegala, L., Tolo, J., Maejima, Y., Yokoi, N., Minami, Y., Miki,T., Rorsman, P., Seino, S. (2020) Gs/Gq signaling switch in β-cells defines incretin effectiveness in diabetes. J Clin Invest 130(12):6639-6655, 2020.

Moriyama, Y., Hatano, R., Moriyama, S., Uehara, S. (2020) Vesicular polyamine transporter as a novel player in amine-mediated chemical transmission. Biochim Biophys Acta Biomembr 1862(12):183208, 2020.

2019

Miyamoto, J., Igarashi, M., Watanabe, K., Karaki, SI., Mukouyama, H., Kishino, S., Li, X., Ichimura, A., Irie, J., Sugimoto, Y., Mizutani, T., Sugawara, T., Miki, T., Ogawa, J., Drucker, D.J., Arita, M., Itoh, H., Kimura, I. (2019) Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids. Nat Commun 10(1):4007.
Lee, E., Miedzybrodzka, E.L., Zhang, X., Hatano, R., Miyamoto, J., Kimura, I., Fujimoto, K., Uematsu, S., Rodriguez-Cuenca, S., Vidal-Puig, A., Gribble, F.M., Reimann, F., Miki, T. (2019) Diet-induced obese mice and leptin-deficient Lepob/ob mice exhibit increased circulating GIP levels produced by different mechanisms. Int J Mol Sci 20 (18). pii: E4448
Kasamatsu, A., Uzawa, K., Hayashi, F., Kita, A., Okubo, Y., Saito, T., Kimura, Y., Miyamoto, I., Oka, N., Shiiba, M., Ito, C., Toshimori, K., Miki, T., Yamauchi, M., Tanzawa, H. (2019) Deficiency of lysyl hydroxylase 2 in mice causes systemic endoplasmic reticulum stress leading to early embryonic lethality. Biochem Biophys Res Commun 512(3):486-491.

2018

Miki, T., Lee, E.Y., Eguchi, A., Sakurai, K., Sawabe, Y., Yoshida, T., Saito, K., Yokoh, H., Ishikawa, K., Yokote, K., Kuzuya, T., Miki, E., Mori, C., Nomura, F. (2018) Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance. J Diabetes Investig 9：512-521.

Kitamoto, T., Sakurai, K., Lee E.Y., Yokote, K., Accili, D., Miki, T. (2018) Distinct roles of systemic and local actions of insulin on pancreatic β-cells. Metabolism 81:100-10. doi: 10.1016/j.metabol.2017.12.017.

Watanabe, Y., Kishimoto, T., Miki, T., Seino, S., Nakaya, H., Matsumoto, A. (2018) Ectopic overexpression of Kir6.1 in the mouse heart impacts on the life expectancy. Sci Rep 8(1):11723. doi: 10.1038/s41598-018-30175-5.

Lee, E.Y., Zhang, X., Miyamoto, J., Kimura, I., Taknaka, T., Furusawa, K., Jomori, T., Fujimoto, K., Uematsu, S., Miki, T. (2018) Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway. J Endocrinol 239(3):267-76. doi: 10.1530/JOE-18-0241

2017

Watanabe, Y., Matsumoto, A., Miki, T., Seino, S., Anzai, N., Nakaya, H.(2017) Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes. J Pharmacol Sci 135(1):37-43. doi: 10.1016/j.jphs.2017.08.009.

Miki, T., Lee, E.Y., Eguchi, A., Sakurai, K., Sawabe, Y., Yoshida, T., Saito, K., Yokoh, H., Ishikawa, K., Yokote, K., Kuzuya, T., Miki, E., Mori, C., Nomura, F. (2017) Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance. J Diabetes Investig (in press)

2016

Morimoto, M., Lee, E.Y., Zhang, X., Inaba, Y., Inoue, H., Ogawa, M., Shirasawa, T., Yokosuka, O., Miki, T. (2016) Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. Nutrition & Diabetes (in press)

Yoshida, M., Lee, EY., Kohno, T., Tanaka, T., Miyazaki, M., Miki T. (2016) Importance of hepatocyte nuclear factor 4α in glycerol-induced glucose-6-phosphatase expression in liver. Biomed Res 37(2):85-93, 2016. doi: 10.2220/biomedres.37.85.

Morita, A., Mukai, E., Hiratsuka, A., Takatani, T., Iwanaga, T., Lee, EY., Miki T. (2016) Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function. Endocrine 51(3):429-39. doi: 10.1007/s12020-015-0733-4.

2015

Hirono, S., Lee, EY., Kuribayashi, S., Fukuda, T., Saeki, N., Minokoshi, Y., Iwanaga, T., Miki, T. (2016) Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide. Endocrinology 157(1):245-57. doi: 10.1210/en.2015-1560. Epub 2015 Oct 27.

Lee, EY., Sakurai, K., Zhang, X., Toda, C., Tanaka, T., Jiang, M., Shirasawa, T., Tachibana, K., Yokote, K., Vidal-Puig, A., Minokoshi, Y., Miki, T. (2015) Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in InsrP1195L/+ mice fed high-fat-diet. Scientific Reports 5:17565. doi:10.1038/srep17565

Nakagomi, A., Okada, S., Yokoyama, M., Yoshida, Y., Shimizu, I., Miki, T., Kobayashi, Y., Minamino, T. (2015) Role of the central nervous system and adipose tissue BDNF/TrkB axes in metabolic regulation. npj Aging and Mechanisms of Disease 1, 15009, 2015. doi:10.1038/npjamd.2015.9

Seino, Y., Ogata, H., Maekawa, R., Iida, A., Harada, N., Miki, T., Inagaki, N., Tsunekawa, S., Seino, S., Oiso, Y., Hamada, Y. (2015) Fructose induces KATP channel-independent GIP and GLP-1 secretion and KATP channel-dependent insulin secretion J Diabetes Investig 6:522-526.

Lee EY, Kaneko S, Jutabha P, Zhang X, Seino S, Jomori T, Anzai N, Miki T. (2015) Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion. J Endocrinol 224(3):205-14.

Matsushita, K., Kitamura, K., Rahmutulla, B., Tanaka, N., Ishige, T., Satoh, M., Hoshino, T., Miyagi, S., Mori, T., Itoga, S., Shimada, H., Tomonaga, T., Kito, M., Nakajima-Takagi, Y., Kubo, S., Nakaseko, C., Hatano, M., Miki, T., Matsuo, M., Fukuyo, M., Kaneda, A., Iwama, A., Nomura, F. (2015) Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute　lymphoblastic leukemia progression by activating Notch1. Oncotarget. 6, 5102-5117.

Oarada, M., Takahashi-Nakaguchi, A., Abe, T., Nikawa, T., Miki, T. Gonoi, T. (2015) Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice.  Nutrition. 31, 757-765.

2014

Ogata, H., Seino, Y., Harada, N., Iida, A., Suzuki, K., Izumoto, T., Ishikawa, K., Uenishi, E., Ozaki, N., Hayashi, Y.,　Miki, T., Inagaki, N., Tsunekawa, S., Hamada, Y., Seino, S., Oiso, Y. (2014)KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. J Endocrinol. 222(2):191-200.

Kawamoto, K., Yabe, S., Konno, M., Ishii, H., Nishida. N., Jun Koseki, J., Fukuda, S., Tomimaru, Y., Hama, N., Wada H., Kobayashi, S., Eguchi, H., Tanemura, M., Ito, T., Lee, E-Y., Mukai, E., Miki, T., Doki, Y., Mori, M., Hamazaki, T., Nagano, H., Okochi, H. (2014) Murine insulinoma cell-conditioned medium with ΒETA2/Neurod1 transduction efficiently induces the differentiation of adipose-derived mesenchymal stem cells into β-like cells both in vitro and in vivo. Stem Cell Research & Therapy 4:8

Mukai E, Ohta T, Kawamura H, Lee EY, Morita A, Sasase T, Miyajima K, Inagaki N, Iwanaga T, Miki T.(2014)   Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in Spontaneously Diabetic Torii rats. Diabetes Res Clin Pract. 106:303-11.

2013

Oarada, M., Miki, T., Kohno, S., Sakai, K., Nikawa, T., Yoneyama, M., Gonoi, T.(2013) Refeeding with a
standard diet after a 48-h fast elicits an inflammatory response in the mouse liver. J Nutr Biochem 24(7):1314-23.

Seino, Y., Miki, M., Fujimoto, W., Lee, EY., Takahashi, Y., Minami, K., Oiso, Y., Seino, S. (2013) Cephalic phase insulin secretion is KATP channel-independent. J Endocrinol  218(1):25-33..

2012

Sakurai, K., Lee, EY., Morita, A., Kimura, S., Kawamura, H., Kasamatsu, A.,Shiiba, M., Yabe, D., Yokote,K., Miki, T. (2012) Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive sweetener. J Diabetes Invest 3:156-63

Ogata, S., Miki, T., Seino, S., Tamai, S., Kasai, H., Nemoto, T. (2012) A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. PLoS ONE 12;7(5):e37048.

2011

Iwanaga, T., Miki, T., Takahashi-Iwanaga, H. (2011) Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenophysis of mice. Biomed Res 32:73-81.

 

Nishida, A., Takizawa, T., Matsumoto, A., Miki, T., Seino, S., and Nakaya, H. (2011) Inhibition of  ATP-Sensitive K(+) Channels and L-Type Ca(2+) Channels by Amiodarone Elicits Contradictory Effect on Insulin Secretion in MIN6 Cells. J Pharmacol Sci 116(1):73-80.

Nakamura, K., Minami, K., Tamura, K., Iemoto, K., Miki, T., and Seino, S. (2011) Pancreatic β-cells are generated by neogenesis from non-β-cells after birth. Biomed Res 3:167-74.
　　　　
Sakurai, K., Lee, EY., Morita, A., Kimura, S., Kawamura, H., Kasamatsu, A.,Shiiba, M., Yabe, D., Yokote,K., Miki, T. (2011) Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar versus non-nutritive sweetener. J Diabetes Invest (in press)

Lee, EY., Inoue, S., Senoo, A., Shimizu, H., Suzuki Y., Ishizuka, N., Imazeki, N., Sasaki, K., Kako, M., Osaka, T., Miki, T. (2011) Beneficial effects of ventromedial hypothalamus (VMH) lesioning on function and morphology of the liver after hepatectomy in rats. Brain Res (in press)　　　　　　　　　
　

2010

Yasuda, T., Shibasaki, T., Minami, K., Takahashi, H., Mizoguchi, A., Uriu, Y., Mori, Y., Miyazaki, J-I, Miki,T., and Seino, S.(2010) Rim2α determines docking and priming states in insulin granule exocytosis. Cell Metab 12(2):117-129.

Iwasaki, M., Minami K., Shibasaki, T., Miki, T., Jun-ichi Miyazaki, J-I., and Seino, S. (2010) Establishment of new clonal pancreatic β-cell lines (MIN6-K) useful for study of incretin/cAMP signaling. J Diabetes Invest 4, 137-142　

2009

Ravier, M.A., Nenquin, M., Miki, T., Seino, S., and Henquin, JC. (2009) Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking ATP-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2. Endocrinology 150:33-45.

Niimura,M., Miki,T., Shibasaki,T., Fujimoto, W., Iwanaga,T., and Seino S. (2009) Critical role of the N-termial cyclic AMP-binding domain of Epac2A in its subcellular localization and function J Cell Physiol 219(3):652-658.

Zlatkovic J, Arrell DK, Kane GC, Miki T, Seino S, Terzic A. (2009) Proteomic profiling of KATP channel-deficient hypertensive heart maps risk for maladaptive cardiomyopathic outcome. Proteomics 9(5):1314-1325.

Fujimoto, W., T. Miki1, T., Ogura, T., Zhang, M., Seino, Y., Satin, L.S., Nakaya, H., Seino, S. (2009) Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice. Diabetologia 52(5):863-872.

Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, Seino S.(2009) The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 325(5940):607-610.

Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ Jr, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y.(2009) LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab 10:296-308.

上へ戻る

2008

Seino, Y., Miki, T., Kiyonari, H., Abe, T., Fujimoto, W., Kimura, K., Takeuchi, A., Takahashi, Y., Oiso, Y., Iwanaga, T. and Seino, S. (2008) Intestine specific homeobox (ISX) participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15, 15'-monooxygenase (bcmo1) expression. J. Biol. Chem. 283(8):4905-4911.

Fukuzaki, K., Sato, T., Miki, T., Seino, S., Nakaya, H. (2008) Role of sarcolemmal ATP-sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice. J. Physio: 5811)2767-2778.

Kentner, A.C., Takeuchi, A., James, J.S., Miki, T., Seino, S., Hayley, S., Bielajew, C. (2008) The effects of rewarding ventral tegmental area stimulation and environmental enrichment on lipopolysaccharide-induced sickness behavior and cytokine expression in female rats. Brain Res. 1217:50-61.

Yamada, S., Nelson, T.J., Crespo, R., Terzic, C., Liu, X.K., Miki, T., Seino, S., Behfar, A., Terzic, A. (2008) Embryonic stem cell therapy of heart failure in genetic cardiomyopathy. Stem Cells 26:2644-2653.

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2007

Miyake, A., Yamada, K., Kosaka, T., Miki, T., Seino, S. and Inagaki, N. (2007) Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice. Eur. J. Neurosci. 25, 2349-2363.

Fujimoto, W.*, Shiuchi, T.*, Miki, T.* (*; contributed equally), Minokoshi, Y., Takahashi, Y., Takeuchi, A., Kimura, K., Saito, M., Iwanaga, T., and Seino, S. (2007) Dmbx1 is essential in agouti-related protein action. Proc. Natl. Acad. Sci. U S A. 104, 15514-15519.

Shibasaki, T., Takahashi, H., Miki, T., Sunaga, Y., Matsumura, K., Yamanaka, M., Zhang, C., Tamamoto, A., Satoh, T., Miyazaki, J-I., and Seino, S. (2007) Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc. Natl. Acad. Sci. U S A. 104(49):19333-193338.

Xu, J., Zhang, L., Allaby, T., Chou, A., Belanger, G., Radziuk, J., Jasmin, B.J., Miki, T., Seino, S., and Renaud, J-M. (2007) KATP channel deficient pancreatic s-cells are streptozotocin resistant due to lower GLUT2 activity.  Am. J. Physiol. Endocrinol. Metab 292(4):H1706-713.

Reyes, S., Kane, G.C., Miki, T., Seino, S., and Terzic, A. (2007) KATP channels confer survival advantage in cocaine  overdose. Mol. Psychiatry. 12(12):1060-1061.

上へ戻る

2006

Zhang, C., Miki, T., Shibasaki, T., Yokokura, M., Saraya, A. and Seino, S. (2006) Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol. Genomics 24, 290-297

Sun, H.S., Feng, Z.P., Miki, T., Seino, S. and French, R.J. (2006) Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels. J. Neurophysiol. 95, 2590-2601

Deacon, R.M., Brook, R.C., Meyer, D., Haeckel, O., Ashcroft, F.M., Miki, T., Seino, S. and Liss, B. (2006) Behavioral phenotyping of mice lacking the K(ATP) channel subunit Kir6.2. Physiol. Behav. 87, 723-733

Oyama, K., Minami, K., Ishizaki, K., Fuse, M., Miki, T., and Seino, S. (2006) Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice. Diabetes 55, 1930-1938.

Choeiri, C., Staines, W.A., Miki, T., Seino, S., Renaud, J.M., Teutenberg, K. and Messier, C. (2006) Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2(-/-) knockout mice. Behav. Brain Res. 172, 233-239.

Kane, G.C., Behfar, A., Dyer, R.B., O'Cochlain, D.F., Liu, X.K., Hodgson, D.M., Reyes, S., Miki, T., Seino, S. and Terzic, A. (2006) KCNJ11 gene knockout of the Kir6.2 KATP channel causes maladaptive remodeling and heart failure in hypertension. Hum. Mol. Genet. 15, 2285-2297.

Yamada, S., Kane, G.C., Behfar, A., Liu, X.K., Dyer, R.B., Faustino, R.S., Miki, T., Seino, S. and Terzic, A. (2006) Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. J. Physiol. 577, 1053-1065.

Kane, G.C., Lam, C.F., O'Cochlain, F., Hodgson, D.M., Reyes, S., Liu, X.K., Miki, T., Seino, S., Katusic, Z.S. and Terzic, A. (2006) Gene knockout of the KCNJ8-encoded Kir6.1 KATP channel imparts fatal susceptibility to endotoxemia. FASEB J. 20, 2271-2280.

Gumina, R., O'cochlain, D.F., Kurtz, C., Bast, P., Pucar, D., Mishra, P., Miki, T., Seino, S., Macura, S. and Terzic, A. (2006) KATP channel knockout worsens myocardial calcium stress-load in vivo and impairs recovery in stunned heart. Am. J. Physiol. Heart Circ. Physiol. 292, H1706-1713.

Olson, T.M., Alekseev, A.E., Moreau, C., Liu, X.K., Zingman, L.V., Miki, T., Seino, S., Asirvatham, S.J., Jahangir, A. and Terzic, A. (2006) KATP channel mutation confers risk for adrenergic atrial fibrillation originating from vein of  Marshall. Nat. Clin. Pract. Cardiovasc. Med. 4, 110-116.

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2005

Saito, T., Sato, T., Miki, T., Seino, S. and Nakaya, H. (2005) Role of ATP-sensitive K+ channels in electrophysiological alterations during myocardial ischemia: a study using Kir6.2-null mice. Am. J. Physiol. Heart Circ. Physiol. 288, H352-357

 

Miki, T., Minami, K., Shinozaki, H., Matsumura, K., Saraya, A., Ikeda, H., Yamada, Y., Holst, J.J. and Seino, S. (2005) Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes 54, 1056-1063

Choeiri, C., Staines, W., Miki, T., Seino, S. and Messier, C. (2005) Glucose transporter plasticity during memory processing. Neuroscience 130, 591-600.

Kimura, K., Miki, T., Shibasaki, T., Zhang, Y., Ogawa, M., Saisho, H., Okuno, M., Iwanaga, T. and Seino, S. (2005) Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579, 2926-2932.

Thabet, M., Miki, T., Seino, S. and Renaud, J.M. (2005) Treadmill running causes significant fiber damage in skeletal muscle of KATP channel deficient mice. Physiol. Genomics 22, 204-212.

Matsumura, K., Miki, T., Jhomori, T., Gonoi, T. and Seino, S. (2005) Possible role of PEPT1 in gastrointestinal hormone secretion. Biochem. Biophys. Res. Commun. 336, 1028-1032.

Liss, B., Haeckel, O., Wildmann, J., Miki, T., Seino, S. and Roeper J. (2005) KATP channel promote the differential degeneration of dopaminergic midbrain neurons. Nat. Neurosci. 8, 1742-1751.

Miki, T. and Seino, S. (2005) Roles of KATP channels as metabolic sensors in acute metabolic changes. J. Mol. Cell. Cardiol. 38:917-925.

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2004

Matsumoto, M., Miki, T., Shibasaki, T., Kawaguchi, M., Shinozaki, H., Nio, J., Saraya, A., Koseki, H., Miyazaki, M., Iwanaga, T. and Seino, S. (2004) Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Proc. Natl. Acad. Sci. U S A 101, 8313-8318.

 

Nishimura, M., Yokoi, N., Miki, T., Horikawa, Y., Yoshioka, H., Takeda, J., Ohara, O. and Seino, S. (2004) Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. DNA Res. 11, 315-323.

Liu, X.K., Yamada, S., Kane, G.C., Alekseev, A.E., Hodgson, D.M., O'Cochlain, F., Jahangir, A., Miki, T., Seino, S. and Terzic, A. (2004) Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. Diabetes 53 Suppl 3, S165-168.

Kane, G.C., Behfar, A., Yamada, S., Perez-Terzic, C., O'Cochlain, F., Reyes, S., Dzeja, P.P., Miki, T., Seino, S. and Terzic, A. (2004) ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. Diabetes 53 Suppl 3, S169-175.

Minami, K., Miki, T., Kadowaki, T. and Seino, S. (2004) Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice. Diabetes 53 Suppl 3, S176-180.

Remedi, M.S., Koster, J.C., Markova, K., Seino, S., Miki, T., Patton, B.L., McDaniel, M.L. and Nichols, C.G. (2004) Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels. Diabetes 53, 3159-3167.

Seino, S. and Miki, T. (2004) Gene targeting approach to clarification of ion channel function: studies of Kir6.x null mice. J. Physiol. 554:295-300.

2003

Suzuki, M., Saito, T., Sato, T., Tamagawa, M., Miki, T., Seino, S. and Nakaya, H. (2003) Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice. Circulation 107, 682-685

Gumina, R.J., Pucar, D., Bast, P., Hodgson, D.M., Kurtz, C.E., Dzeja, P.P., Miki, T., Seino, S. and Terzic A. (2003) Knockout of the KATP channel subunit Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics. Am. J. Physiol. Heart Circ. Physiol. 284, H2106-2113.

Niki, I., Niwa, T., Yu, W., Budzko, D., Miki, T. and Senda T. (2003) Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution. Exp. Biol. Med. (Maywood) 228, 1218-1226.

Gong, B., Legault, D., Miki, T., Seino, S. and Renaud, J.M. (2003) KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle. Am. J. Physiol. Cell Physiol. 285, C1464-1474.

Minami, K., Morita, M., Saraya, A., Yano, H., Terauchi, Y., Miki, T., Kuriyama, T., Kadowaki, T. and Seino, S. (2003) ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling. Am. J. Physiol. Endocrinol. Metab. 285, E1289-1296.

Seino. S. and Miki, T. (2003) Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog. Biophys. Mol. Biol. 81, 133-176.

2002

Suzuki, M., Sasaki, N., Miki, T., Sakamoto, N., Ohmoto-Sekine, Y., Tamagawa, M., Seino, S., Marban, E., and Nakaya, H. (2002) Role of sarcolemmal KATP channels in cardioprotection against ischemia/reperfusion injury in mice. J. Clin. Invest. 109, 509-516.

Miki, T., Suzuki, M., Shibasaki, T., Uemura, H., Sato, T., Yamaguchi, K., Koseki, H., Iwanaga, T., Nakaya, H. and Seino, S. (2002) Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat. Med. 8, 466-472

Zhang, Y., Miki, T., Iwanaga, T., Koseki, Y., Okuno, M., Sunaga, Y., Ozaki, N., Yano, H., Koseki, H. and Seino, S. (2002) Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family. J. Biol. Chem. 277, 28065-28069.

Miki, T., Minami, K., Zhang, L., Morita, M., Gonoi, T., Shiuchi, T., Minokoshi, Y., Renaud, J.M. and Seino, S. (2002) ATP-sensitive potassium channels participate in glucose uptake in skeletal muscle and adipose tissue. Am. J. Physiol. Endocrinol. Metab. 283, E1178-84.

Zingman, L.V., Hodgson, D.M., Bast, P.H., Kane, G.C., Perez-Terzic, C., Gumina, R.J., Pucar, D., Bienengraeber, M., Dzeja, P.P., Miki, T., Seino, S., Alekseev, A.E, and Terzic. A. (2002) Kir6.2 is required for adaptation to stress. Proc. Natl. Acad. Sci. USA 99, 13278-13283.

2001

Nishigori, H., Tomura, H., Tonooka, N., Kanamori, M., Yamada, S., Sho, K., Inoue, I., Kikuchi, N., Onigara, K., Kojima, I., Kohama, T., Yamagata, K., Yang, Q., Matsuzawa, Y., Miki, T., Seino,S., Kim, M-Y., Choi, H-S., Lee, Y-K., Moore, D.D. and Takeda, J. (2001) Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects. Proc. Natl. Acad. Sci. USA 98, 575-580.

Miki, T., Iwanaga, T., Nagashima, K. and Seino, S. (2001) Roles of the KATP channels in cell survival and differentiation of endocrine pancreas. Diabetes 50 Suppl 1, S48-51. Winarto, A., Miki, T., Seino, S., Iwanaga, T. (2001) Morphological changes in pancreatic islets of KATP channel-deficient mice: the involvement of KATP channels in the survival of insulin cells and the maintenance of islet architecture. Arch. Histol. Cytol. 64, 59-67.

Suzuki, M., Li, R.A., Miki, T., Uemura, H., Sakamoto, N., Ohmoto-Sekine, Y., Ogura, T., Tamagawa, M., Seino, S. and Nakaya, H. (2001) Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout nice. Circ. Res. 88, 570-577.

Yamada, K., Ji, J.J., Yuan, H., Miki, T., Sato, S., Horimoto, N., Shimizu, T., Seino, S. and Inagaki, N. (2001) Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292, 1543-1546.

Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J. and Seino, S. (2001) ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat. Neurosci. 5, 507-512.

Sano, R., Miki, T., Suzuki, Y., Shimada, F., Taira, M., Kanatsuka, A., Makino, H., Hashimoto, N. and Saito, Y. (2001) Analysis of the insulin-sensitive phosphodiesterase 3B gene in type 2 diabetes. Diabetes Res. Clin. Pract. 54, 79-88.

Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H. and Seino, S. (2001) Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 276, 46046-46053.

2000

Mitsuhashi, N., Miki, T., Senbongi, H., Yokoi, N., Yano, H., Miyazaki, M., Nakajima, N., Iwanaga,T., Yokoyama, Y., Shibata, T. and Seino, S. (2000) MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J. Biol. Chem. 275, 17536-17540.

Minami, K., Yano, H., Miki, T., Nagashima, K., Tanaka, H., Wang, C-Z., Miyazaki, J. and Seino, S. (2000) Insulin secretion and differential gene expression in glucose-responsive and -unresponsive MIN6 sublines. Am. J. Physiol. Endocrinol. Metab. 279: E773-E781.

Gong, B., Miki, T., Seino, S. and Renaud, J.M. (2000) A K+ATP channel deficiency affects resting tension, not contractile force, during fatigue in skeletal muscle. Am. J. Physiol. Cell Physiol. 279, C1351-C1358.

Ozaki, N., Shibasaki, T., Kashima, Y., Miki, T., Takahashi, K., Ueno, H., Sunaga, Y., Yano, H., Iwanaga, T., Matuura, Y., Takai, Y. and Seino, S. (2000) cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat. Cell Biol. 2, 805-811.

Li, R.A., Leppo, M., Miki, T., Seino, S. and Marban, E. (2000) Molecular basis of electrocardiographic ST segment elevation. Circ. Res. 87, 837-839

Someya, T., Miki, T., Sugihara, S., Minagawa, M., Yasuda, T., Kohno, Y. and Seino, S. (2000) Characterization of genes encoding the pancreatic s-cell ATP-sensitive K+ channel in persistent hyperinsulinemic hypoglycemia of infancy in Japanese patients. Endocrine. J. 47, 715-722.

Seino, S., Iwanaga, T., Nagashima, K. and Miki, T. (2000) Diverse roles of KATP channels learned from Kir6.2 genetically engineered mice. Diabetes 49, 311-318.

1999

Nishimura, M., Miki, T., Yokoi, N., Yano, H., Sato, Y. and Seino, S. (1999) Angiopoietin-3, a novel member of the anigiopoietin family. FEBS Lett. 448, 254-256.

Kawaki, J., Nagashima, K., Tanaka, J., Miki, T., Miyazaki, T., Gonoi, T., Nakajima, N., Iwanaga, T., Yano, H. and Seino, S. (1999) Unresponsiveness to glibenclamide during chronic treatment induced by reduction of ATP-sensitive K+ channel activity. Diabetes 48, 2001-2006.

Miki, T., Inagaki, N., Nagashima, K., Gonoi, T., and Seino, S. (1999) Structure and Function of ATP-sensitive K+ channels. Current Topics in Membranes 46, 373-385.

Miki, T., Nagashima, K., and Seino, S. (1999) The structure and function of the ATP-sensitive K+ channel in insulin secreting pancreatic s-cells. J. Mol. Endocrinol. 22, 113-123.

1998

Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, JI. and Seino, S. (1998) Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc. Natl. Acad. Sci. USA 95, 10402-10406.

1997

Mizuta, M., Kurose, T., Miki, T., Shoji-Kasai, Y., Takahashi, M., Seino, S. and Matsukura, S. (1997) Localization and functional role of synaptotagmin III in insulin secretory vesicles in pancreatic s-cells. Diabetes 46, 2002-2006.

Miki, T., Tashiro, F., Iwanaga, T., Nagashima, K., Yoshitomi, H., Aihara, H., Nitta, Y., Gonoi, T., Inagaki, N., Miyazaki, JI. and Seino, S. (1997) Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel. Proc. Natl. Acad. Sci. USA 94, 11969-11973.

Seino, S., Inagaki, N., Namba, N., Wang, C-H., Nagashima, K., Miki, T., Agulilar-Bryan, L., Bryan, J. and Gonoi, T. (1997) Molecular basis of functional diversity of ATP-sensitive K+ channels. Jpn. J. Physiol. 47, 3-4.

1996

Miki, T., Taira, M., Hockman, S., Shimada, F., Lieman, J., Napolitano, M., Ward, D., Taira, M., Makino, H. and Manganiello, VC. (1996) Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family. Genomics 36, 476-485.

Nishikawa, T., Iizuka, T., Omura, M., Kuramoto, N., Miki, T., Ito, H., Chiba, S. (1996) Effect of mazindol on body weight and insulin sensitivity in severely obese patients after a very-low-calorie diet therapy. Endocr. J. 43, 671-677.

 

1995

上へ戻る

1994

Shimada, F., Kanatsuka, A., Sakurada, M., Hashimoto, N., Sano, H., Hatanaka, Y., Miki, T., Makino, H. and Yoshida, S. (1994) Insulin response to intravenous glucose in a family with a glucokinase mutation. Horm. Metab. Res. 26, 392-394.