研究内容
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研究業績

2024年

  1. Shin Suzuki, Yuji Morita, Shota Ishige, Kiyohiro Kai, Kenji Kawasaki, Kazuyuki Matsushita, Kohei Ogura, Tohru Miyoshi-Akiyama and Takeshi Shimizu,   Effects of quorum sensing–interfering agents, including macrolides and furanone C-30, and an efflux pump inhibitor on nitrosative stress sensitivity in Pseudomonas aeruginosa. , Microbiology 2024;170:001464 DOI 10.1099/mic.0.001464 
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2023年

  1. 松田 侑里，米倉 修二，須藤 智美，栗田 惇也，新井 智之，飯沼 智久，鈴木 眞，山下 晃司，松下 一之，髙地 祐輔，岸本 充，花澤 豊行　「外科的切除を要した非定型抗酸菌による耳前部リンパ節炎の１例」日本耳鼻咽喉科免疫アレルギー感染症学会誌 3(3): 101–107 (2023)

2022年

  1. Shinichiro HIRAI, Eiji YOKOYAMA, Yuh SHIWA, Taichiro ISHIGE, Naoshi ANDO, Takeshi SHIMIZU, Satoshi MURAKAMI. 2022. Clarification of relationship between single-nucleotide polymorphism panels of Shiga toxin-producing Escherichia coli O157:H7/H- strains. The Journal of Veterinary Medical Science, 84(10): 1399-1405.  doi: 10.1292/jvms.22-0242

2021年

  1. Ogura, K., Yahiro, K., Moss, J. "Cell death signaling pathway induced by Cholix toxin, a cytotoxin and eEF2 ADP-ribosyltransferase produced by Vibrio cholerae " Toxins (2021) 13(1), 12. https://doi.org/10.3390/toxins13010012
  2. Takeshi Shimizu; Manami Onuki; Shin Suzuki; Shinichiro Hirai; Eiji Yokoyama; Akio Matsumoto; Takashi Hamabata. 2021. Enhanced production of Shiga toxin 1 in enterohemorrhagic Escherichia coli by oxygen. Microbiology, 167:001122. doi: 10.1099/mic.0.001122

2020年

  1. Harada, A. Tsutsuki, H. Zhang, T. Lee, R. Yahiro, K. Sawa, T. Niidome, T. " Preparation of Biodegradable PLGA-Nanoparticles used for pH-Sensitive Intracellular Delivery of an Anti-inflammatory Bacterial Toxin to Macrophages." Chem. Pharm. Bull. (2020) 68(4):363-368. doi: 10.1248/cpb.c19-00917.                                                                                                                          
  2. Tsutsuki, H. Zhang, T. Harada, A. Rahman, A. Ono, K. Yahiro, K. Niidome, T. Sawa, T. " Involvement of protein disulfide isomerase in Subtilase cytotoxin-induced cell death in HeLa cells." Biochem. Biophys. Res. Commun. (2020)  doi.org/10.1016/j.bbrc.2020.03.008
  3. Shimizu, T. Miyoshi-Akiyama, T. Ogura, K. Murata, S. Ishige, S. Kai, K. Mitsutsuka, K. Tomita, H. Tanimoto, K. Matsumoto, A. " Effect of sub-MICs of macrolides on the sensitivity of Pseudomonas aeruginosa to nitrosative stress: effectiveness against P. aeruginosa with and without multidrug resistance."Antimicrob. Agents Chemother.(2020)64, e01180-20. doi.org/10.1128/AAC.01180-20
  4. Tsutsuki, H. Ogura, K. Moss, J. Yahiro, K." Host response to the Subtilase cytotoxin produced by locus of enterocyte effacement (LEE)-negative Shiga-toxigenic Escherichia coli (STEC)" Microbiology and Immunology. (2020). doi.org/10.1111/1348-0421.12841
  5. Yahiro, K., Ogura, K., Goto, Y., Iyoda, S., Kobayashi, T., Takeuchi, H., Ohnishi, M., Moss, J. " Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival." Scientific Reports. (2020)　https://doi.org/10.1038/s41598-020-76027-z

 

2019年

  1. Suzuki, K. Ataka, A. Asakawa, K, Cheng. M, Ushikai. H. Iwai, T. Arai, K. Yahiro, K. Yamamoto, Y. Yokoyama, M. Kojima, T. Yada, T. Hirayama, N. Nakamura, A. Inui, "Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via 1 Hypothalamic Urocortin 1 in Mice." Scientific Reports (2019) 12;9(1):6011. https://doi.org/10.1038/s41598-019-42163-4

  2. Yahiro, K. Ogura, K. Terasaki, Y.  Satoh, M. Miyagi, S. Terasaki, M. Yamasaki, E. Moss, J. ”Cholix toxin, an eEF2 ADP-ribosyltransferase, interacts with Prohibitins and induces apoptosis with mitochondrial dysfunction in human hepatocytes.” Cellular Microbiology (2019)  22:e13033　doi.org/10.1111/cmi.13033

  3. Yamaji, T. Hanamatsu, H. Sekizuka, T. Kuroda, M. Iwasaki, N. Ohnishi, M. Furukawa, J. Yahiro, K. Hanada, K. “A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-regulating Factor” iScience (2019) May 8;15:407-420.doi.org/10.1016/j.isci.2019.05.005

  4. Shimizu, T. Matsumoto, A. Noda, M. 2019. Cooperative roles of NO-metabolizing enzymes to counteract nitrosative stress in enterohemorrhagic Escherichia coli. Infect. Immun., (2019)  87: e00334-19., doi:10.1128/IAI.00334-19
  5. 八尋錦之助「何でも答えます！Helicobacter pylori 感染症：Helicobacter pylori は除菌しても、井戸水を摂取することで、再感染することはありますか？」Helicobacter Research 23(2):96-97.(2019)
 

2018年

  1. Yahiro, K. Nagasawa, S. Ichimura, K. Takeuchi, H. Ogura, K. Tsutsuki, H. Shimizu, T. Iyoda, S. Ohnishi, M. Iwase, H. Moss, J. & Noda, M. ”Mechanism of inhibition of Shiga-toxigenic Escherichia coli SubAB cytotoxicity by steroids and diacylglycerol analogues” Cell Death Discovery. volume 4, Article number: 22 (2018) https://doi.org/10.1038/s41420-017-0007-4

2017年

  1. 中野政之、八尋錦之助　「Award Report 上原H. Pylori 賞ー優秀賞ー宿主受容体RPTPα を介したVacAの新たな機能」日本ヘリコバクター学会誌　1月号.18（2）：28-31. (2017)
  2. Kimitoshi Ichimura, Takeshi Shimizu, Akio Matsumoto, Shinichiro Hirai, Eiji Yokoyama, Hiroki Takeuchi, Kinnosuke Yahiro and Masatoshi Noda. 2017. Nitric oxide-enhanced Shiga toxin production was regulated by Fur and RecA in enterohemorrhagic Escherichia coli O157. MicrobiologyOpen. doi: 10.1002/mbo3.461
  3. 八尋錦之助、Shelley Starck.「5‘非翻訳領域からの翻訳が統合的ストレス応答に適応する」Science: Japanese Scientists in Science 2016. 19（2017）
  4. Kaung Kyaw, Ayaka Harada, Hiroaki Ichimaru, Takayuki Kawagoe, Kinnosuke Yahiro, Shigeru Morimura, Katsuhiko Ono, Hiroyasu Tsutsuki, Tomohiro Sawa, Takuro Niidome.  Silver Nanoparticles as Potential Antibiofilm Agents Against Human Pathogenic Bacteria. Chemistry Letter (2017) 46, 594–596 | doi:10.1246/cl.161198
  5. Kohei Ogura, Yasuhiro Terasaki, Tohru Miyoshi-Akiyama, Mika Terasaki, Joel Moss, Masatoshi Noda and Kinnosuke Yahiro. 2017. Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases. Toxicological Sciences https://doi.org/10.1093/toxsci/kfx009

2016年

  1. Nakano, M. Yahiro, K. Yamasaki, E. Kurazono, H. Akada, J. Yamaoka, Y. Niidome, T.  Hatakeyama, M. Suzuki, H. Yamamoto, T. Moss, J. Isomoto, H. Hirayama, T. 2016. Helicobacter pylori VacA acting through receptor protein tyrosine phosphatase alpha is critical for CagA phosphorylation in AZ-521 cells. Disease Models & Mechanisms. 2016  9: 1473-1481;  doi: 10.1242/dmm.025361.
  2. Starck, S., Tsai, J. Chen, K. Shodiya, M. Wang, L. Yahiro, K. Martin-Green, M. Shastri, N. Walter,P. 2016. Translation from the 5’untranslated region shapes the integrated stress response. Science. 351: issue 6272.
  3. Shimizu, T. Ichimura, K. Noda, M. 2016. The surface sensor NlpE of enterohemorrhagic Escherichia coli contributes to regulation of the type III secretion system and flagella by the Cpx response to adhesion. Infect. Immun., 84, 537-549.
  4. Tsutsuki, H. Yahiro, K.  Ogura, K. Ichimura, K. Iyoda,S. Ohnishi, M. Nagasawa, S. Moss, J.  Noda, M. 2016. Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation. Cellular Microbiology. doi: 10.1111/cmi.12565.
  5. Yahiro, K. Hirayama, T. Moss, J. Noda,M.  2016. New Insights into VacA intoxication mediated through its cell surface receptors. Toxins (Review), 8, 152; doi:10.3390/toxins 8050152..
  6. 八尋錦之助. 2016.「腸管出血性大腸菌感染の現状と病原性」化学療法の領域 4月号.32(4):70-76. 

2015年

  1. Takeshi Shimizu, Shinichiro Hirai, Eiji Yokoyama, Kimitoshi Ichimura and Masatoshi Noda,, 2015. An evolutionary analysis of nitric oxide reductase gene norV in enterohemorrhagic Escherichia coli O157. Infect. Genet. Evol., 33, 176-181.
  2. Yahiro, K., Y. Akazawa, M. Nakano, H. Suzuki, J. Hisatune, H. Isomoto, J. Sap, M. Noda, J. Moss, T. Hirayama. 2015. Helicobacter pylori VacA induces apoptosis by accumulation of connexin 43 in autophagic vesicles via a Rac1/ERK-dependent pathway. Cell Death Discovery. 1:15035.
  3. Yahiro, K., T. Hirayama, J. Moss, M. Noda. 2015. Helicobacter pylori VacA toxin causes cell death by inducing accumulation of cytoplasmic connexin 43. Cell Death Disease. 6: e1971
  4. 清水　健、藤永由佳子、高屋明子、芦田　浩、児玉年央、畠山昌則「細菌エフェクター・細菌毒素の分子標的と疾病脆弱性」日本細菌学雑誌、2015, 70：319-328. 

2014年

  1. Nagasawa, S., K. Ogura, H. Tsutsuki, H. Saitoh, J. Moss, H. Iwase, M. Noda, K. Yahiro. 2014. Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin-and lipid raft-dependent pathway. Cellular Microbiology. 16:1582-1601.
  2. Yahiro, K., H. Tsutsuki, K. Ogura, S. Nagasawa, J. Moss, M. Noda. 2014. DAP1, a Negative Regulator of Autophagy, Controls SubAB-Mediated Apoptosis and Autophagy. Infect. Immun. 82: 4899-4908.
  3. 清水　健、野田公俊「病原性大腸菌による感染症　—腸管出血性大腸菌を中心に- 」千葉医学雑誌、2014, 90, 47-52.
  4. 清水　健「腸管出血性大腸菌の重症化メカニズム：病原性と志賀毒素」感染症内科、2014, 2(4), 377-384.
  5. 清水　健「志賀毒素２(Stx2)の病原性発現機構」感染炎症免疫、2014, 44, 67-69.

2013年

  1. Arimitsu, H. K. Sasaki, T. Shimizu, K. Tsukamoto, T. Shimizu. T. Tsuji. 2012. Large‐scale preparation of Shiga toxin 2 in Escherichia coli for toxoid vaccine antigen production. Microbiol. Immunol. 57:38-45.
  2. 中野政之、八尋錦之助、平山壽哉. 2013.「Helicobacter pylori の病原因子」臨床と微生物 3月号. 40(2): 178-181.
  3. 清水　健、野田公俊「腸管出血性大腸菌の重症化要因」感染炎症免疫、2013, 43, 74-7
  4. 八尋　錦之助. 2013.「Helicobacter pylori VacA 受容体とオートファジー・アポトーシスの誘導」Helicobacter Research 10月号.17（5）：34-38.

2012年

  1. Yahiro, K., H. Tsutsuki, K. Ogura, S. Nagasawa, J. Moss, and M. Noda. 2012. Regulation of Subtilase cytotoxin (SubAB)-induced cell death by a PKR-like endoplasmic reticulum kinase (PERK)-dependent proteasome pathway in HeLa cells. Infect Immun 80:1803-1814.
  2. Yahiro, K., M. Satoh, M. Nakano, J. Hisatsune, H. Isomoto, J. Sap, H. Suzuki, F. Nomura, M. Noda, J. Moss, T. Hirayama. 2012. Low-density Lipoprotein Receptor-related Protein-1 (LRP1) Mediates Autophagy and Apoptosis Caused by Helicobacter pylori VacA. J. Biol. Chem. 287:31104-31115.
  3. Tsutsuki, H., K. Yahiro, K. Suzuki, A. Suto, K. Ogura, S. Nagasawa, H. Ihara, T. Shimizu, H. Nakajima, J. Moss, M. Noda. 2012. Subtilase Cytotoxin Enhances Escherichia coli Survival in Macrophages by Suppression of Nitric Oxide Production through the Inhibition of NF-kappa B Activation. Infect. Immun. 80: 3939-3951.
  4. Shimizu, T., H. Tsutsuki, A. Matsumoto, H. Nakaya, M. Noda. 2012. The nitric oxide reductase of enterohemorrhagic Escherichia coli plays an important role for the survival within macrophages. Mol. Microbiol. 85:492-512.
  5. Neri, P., S. Tokoro, T. Sugiyama, K. Umeda, T. Shimizu, T. Tsuji, Y. Kodama. H. Mori. 2012. Recombinant Shiga toxin B subunit can induce neutralizing immunoglobulin Y antibody. Biol. Pharm. Bull. 35: 917-923.
  6. 清水　健、野田公俊. 2012.「腸管出血性大腸菌による食中毒重症化メカニズム」日本医事新報.4614:98-99.
  7. 八尋錦之助. 2012.「腸管出血性大腸菌の病原性発現機構」化学療法の領域 6月号.28(6):45-52.

2011年

  1. Shimizu, T., Y. Ohta, H. Tsutsuki, and M. Noda. 2011. Construction of a novel bioluminescent reporter system for investigating Shiga toxin expression of enterohemorrhagic Escherichia coli. Gene 478:1-10.
  2. Yahiro, K., M. Satoh, N. Morinaga, H. Tsutsuki, K. Ogura, S. Nagasawa, F. Nomura, J. Moss, and M. Noda. 2011. Identification of Subtilase cytotoxin (SubAB) receptors whose signaling, in association with SubAB-induced BiP cleavage, is responsible for apoptosis in HeLa cells. Infect Immun 79:617-627.
  3. Furukawa, T., K. Yahiro, A. B. Tsuji, Y. Terasaki, N. Morinaga, M. Miyazaki, Y. Fukuda, T. Saga, J. Moss, and M. Noda. 2011. Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli. Microb Pathog 50:159-167.
  4. Ogura, K., K. Yahiro, H. Tsutsuki, S. Nagasawa, S. Yamasaki, J. Moss, and M. Noda. 2011. Characterization of cholix toxin-induced apoptosis in hela cells. J Biol Chem 286:37207-37215. 

2010年

  1. Morinaga, N., K. Yahiro, and M. Noda. 2010. Resveratrol, a natural polyphenolic compound, inhibits cholera toxin-induced cyclic AMP accumulation in Vero cells. Toxicon 56:29-35.
  2. Yahiro, K., N. Morinaga, J. Moss, and M. Noda. 2010. Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling. Microb Pathog 49:153-163.