2010年08月31日
G-COE セミナー（グローバルＣＯＥプログラム主催）
日時 ： 平成22年8月31日（火曜日）17時〜18時
場所 ： 大カンファレンスルーム
タイトル ： Epithelial cells initiate TH2 immunity during allergy and worm infection
講師 ： Dr. DeBroski Herbert
Assistant Professor, Division of Immunobiology
Cincinnati Children's Research Foundation
セミナーの概要 ：
The rising incidence of allergy and asthma most
likely represents misdirected T helper type 2 immune responses that evolved for
host-protection against parasitic helminths. Despite several decades of
research, mechanisms responsible for initial development of CD4+TH2
cells from naïve T cell precursors remain elusive. Epithelial cell derived
cytokines such as interleukins 25, 33 (IL-25, IL-33) and thymic stromal
lymphopoietin (TSLP) have been implicated in driving TH2
polarization, but the initial stimuli that cause release of these cytokines is
entirely unclear. In this study, new evidence will be discussed that shows how
trefoil factors (TFF), mucus-associated proteins, are a critical first-step in
differentiation of TH2 cells through mechanisms dependent upon
alternative macrophage activation.
Data will be presented in mouse models of infection with the hookworm Nippostrongylus brasiliensis and
IL-13-dependent murine asthma.
This work provides a potential mechanism to explain how T cell
differentiation is shaped by innate immune responses that occur rapidly
following pathogen infestation within the intestinal and lung mucosa.
