2024
Iwasaki K, Tojo A, Kobayashi H, Shimizu K, Kamimura Y, Fukuto A, Horikoshi Y, Sun J, Yasui M, Honma M, Okabe A, Fujiki R, Nakajima N, Kaneda A, Tashiro S, Sassa A, Ura K. Dose-dependent effects of histone methyltransferase NSD2 on site-specific double-strand break repair. Genes Cells, in press.
Kitagawa, Yuki; Kondo, Satoru; Fukuyo, Masaki; Dochi, Hirotomo; Wakae, Kousho ; Mizokami, Harue; Komura, Shigetaka; Kobayashi, Eiji; Hirai, Nobuyuki; Ueno, Takayoshi; Nakanishi, Yosuke; Endo, Kazuhira; Sugimoto, Hisashi; Wakisaka, Naohiro; Kaneda, Atsushi; Yoshizaki, Tomokazu. Phosphoribosyl pyrophosphate amidotransferase: A novel biomarker and therapeutic target for nasopharyngeal carcinoma. Cancer Sci, in press.
Hatano R, Zhang X, Lee E, Kaneda A, Tanaka T, Miki T. Mosaic ablation of pancreatic β-cells induces de-differentiation and repetitive proliferation of residual β-cells in adult mice. iScience, in press.
Shimizu S, Fukuda N, Chen L, Matsumoto T, Kaneda A, Endo M, Nishiyama A, Morioka I. Abnormal epigenetic memory of mesenchymal stem and progenitor cells caused by fetal malnutrition induces hypertension and renal injury in adulthood.Hypertension Res., epub 2024 June 26. doi: 10.1038/s41440-024-01756-x
Hoshii T, Kikuchi S, Kujirai T, Masuda T, Ito T, Yasuda S, Matsumoto M, Rahmutulla B, Fukuyo M, Murata T, Kurumizaka H, Kaneda A. BOD1L mediates chromatin binding and non-canonical function of H3K4 methyltransferase SETD1A. Nucleic Acids Res, epub 2024 Jul 11. doi: 10.1093/nar/gkae605.
Kumagai T, Iwata A, Furuya H, Kato K, Okabe A, Toda Y, Kanai M, Fujimura L, Sakamoto A, Kageyama T, Tanaka S, Suto A, Hatano M, Kaneda A, Nakajima H. Distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation. PNAS, 2024 June; 121: e2320727121. doi: 10.1073/pnas.2320727121.
Paul SK, Oshima M, Patil A, Sone M, Kato H, Maezawa Y, Kaneko H, Fukuyo M, Rahmutulla B, Ouchi Y, Tsujimura K, Nakanishi M, Kaneda A, Iwama A, Yokote K, Eto K, Takayama N. Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Nat Commun, 2024; 15: 4772. doi: 10.1038/s41467-024-48663-w.
Nakayama Y, Fujiu K, Oshima T, Matsuda J, Sugita J, Matsubara TJ, Liu Y, Goto K, Kani K, Uchida R, Takeda N, Morita H, Xiao Y, Hayashi M, Maru Y, Hasumi E, Kojima T, Ishiguro S, Kijima Y, Yachie N, Yamazaki S, Yamamoto R, Kudo F, Nakanishi M, Iwama A, Fujiki R, Kaneda A, Ohara O, Nagai R, Manabe I, Komuro I. Heart failure promotes multimorbidity through innate immune memory. Sci Immunol, 2024 May; 9: eade3814. doi: 10.1126/sciimmunol.ade3814. epub 2024 May 24.
Zhu T, Okabe A, Usui G, Fujiki R, Komiyama D, Huang KK, Seki M, Fukuyo M, Abe H, Ning M, Okada T, Minami M, Matsumoto M, Fan Q, Rahmutulla B, Hoshii T, Tan P, Morikawa T, Ushiku T, Kaneda A. Integrated Enhancer Regulatory Network by Enhancer-Promoter Looping in Gastric Cancer. NAR Cancer, NAR Cancer, epub 2024 May 8. doi: 10.1093/narcan/zcae020.
Chen SJ, Hashimoto K, Fujio K, Hayashi K, Paul SK, Yuzuriha A, Qiu WY, Nakamura E, Kanashiro MA, Kabata M, Nakamura S, Sugimoto N, Kaneda A, Yamamoto T, Saito H, Takayama N, Eto K. A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility. Nat Commun. 2024 Mar; 15:2588. doi: 10.1038/s41467-024-46605-0. epub 2024 Mar 22.
Mizokami H, Okabe A, Choudhary R, Mima M, Saeda K, Fukuyo M, Rahmutulla B, Seki M, Goh BC, Kondo S, Dochi H, Moriyama-Kita M, Misawa K, Hanazawa T, Tan P, Yoshizaki T, Fullwood MJ, Kaneda A. Enhancer infestation drives tumorigenic activation of inactive B compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma. eBioMedicine, 2024 Apr; 102: 105057. doi: 10.1016/j.ebiom.2024.105057. epub 2024 Mar 14.
Kanaoka S, Okabe A, Kanesaka M, Rahmutulla B, Fukuyo M, Seki M, Hoshii T, Sato H, Imamura Y, Sakamoto S, Ichikawa T, Kaneda A. Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer. Cancer Lett, 2024 Apr; 588: 216815. doi: 10.1016/j.canlet.2024.216815. epub 2024 Mar 13.
Takane K, Cai T, Noguchi R, Gohda Y, Ikenoue T, Yamaguchi K, Ota Y, Kiyomatsu T, Yano H, Fukuyo M, Seki M, Rahmutulla B, Kaneda A, Furukawa Y. Genome-wide analysis of DNA methylation in pseudomyxoma peritonei originated from appendiceal neoplasms. Oncology, epub 2024 Jan 23. doi: 10.1159/000536219.
Suda K, Okabe A, Matsuo J, Chuang LSH, Li Y, Jangphattananont N, Mon NN, Myint K, Yamamura A, So JBY, Voon D, Yang H, Guan Y, Kaneda A, Ito Y. Aberrant upregulation of RUNX3 activates developmental genes to drive metastasis in gastric cancer. Cancer Res Commun, 2024 Feb;4(2):279-292. doi: 10.1158/2767-9764.CRC-22-0165.
Dochi H, Kondo S, Komura S, Moriyama-Kita M, Komori T, Nanbo A, Sakaguchi M, Fukuyo M, Hamabe-Horiike T, Tanaka M, Mizokami H, Kano M, Kitagawa Y, Kobayashi E, Hirai N, Ueno T, Nakanishi Y, Endo K, Sugimoto H, Hanayama R, Kaneda A, Yoshizaki T. Peritumoral SPARC expression induced by exosomes from nasopharyngeal carcinoma infected Epstein-Barr virus: a poor prognostic marker. Int J Cancer, 2024;154:895-911. doi: 10.1002/ijc.34777. epub 2023 Oct 31.
2023
Kitamura K, Hoshino T, Okabe A, Fukuyo M, Rahmutulla B, Tanaka N, Kobayashi S, Tanaka T, Shida T, Ueda M, Minamoto T, Matsubara H, Kaneda A, Ishii H, Matsushita K. The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer. Int J Mol Sci. 2023;24:17341. doi: 10.3390/ijms242417341.
Usui G, Matsusaka K, Huang KK, Zhu F, Shinozaki T, Fukuyo M, Rahmutulla B, Yogi N, Okada T, Minami M, Seki M, Sakai E, Fujibayashi K, Tsao SKK, Khor C, Ang TL, Abe H, Matsubara H, Fukayama M, Gunji T, Matsuhashi N, Morikawa T, Ushiku T, Yeoh KG, Tan P, Kaneda A. Integrated Environmental, Lifestyle, and Epigenetic Risk Prediction of Primary Gastric Neoplasia Using the Longitudinally Monitored Cohorts. eBioMedicine, 2023;98:104844. doi: 10.1016/j.ebiom.2023.104844. epub 2023 Oct 26.
Perlee S, Kikuchi S, Nakadai T, Masuda T, Ohtsuki S, Matsumoto M, Rahmutulla B, Fukuyo M, Cifani P, Kentsis A, Roeder RG, Kaneda A, Hoshii T. SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. EMBO Rep, 2023; 24: e57108. doi: 10.15252/embr.202357108. epub 2023 Aug 3.
Ito Y, Usui G, Seki M, Fukuyo M, Matsusaka K, Hoshii T, Sata Y, Morimoto J, Hata A, Nakajima T, Rahmutulla B, Kaiho T, Inage T, Tanaka K, Sakairi Y, Suzuki H, Yoshino I, Kaneda A. Association of frequent hypermethylation with high grade histological subtype in lung adenocarcinoma. Cancer Sci, 2023;114:3003-3013. doi: 10.1111/cas.15817. epub 2023 Apr 21.
Xu C, Huang KK, Law JH, Chua JS, Sheng T, Flores NM, Pizzi MP, Okabe A, Tan ALK, Zhu F, Kumar V, Lu X, Benitez AM, Lian BSX, Ma H, Ho SWT, Ramnarayanan K, Anene-Nzelu CG, Razavi-Mohseni M, Ghani SABA, Tay ST, Ong X, Lee MH, Guo YA, Ashktorab H, Smoot D, Li S, Skanderup AJ, Beer MA, Foo RSY, Wong JSH, Sanghvi K, Yong WP, Sundar R, Kaneda A, Prabhakar S, Mazur PK, Ajani JA, Yeoh KG, So JBY, Tan P, Singapore Gastric Cancer Consortium. Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities. Gut, 2023 Sep;72:1651-1663. doi: 10.1136/gutjnl-2022-328332. epub 2023 Mar 14.
Mima M, Okabe A, Hoshii T, Nakagawa T, Kurokawa T, Kondo S, Mizokami H, Fukuyo M, Fujiki R, Rahmutulla B, Yoshizaki T, Hanazawa T, Misawa K, Kaneda A. Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma. Int J Cancer, 2023;152:1847-1862. doi:10.1002/ijc.34439. epub 2023 Jan 17.
2022
Hoshii T, Perlee S, Kikuchi S, Rahmutulla B, Fukuyo M, Masuda T, Ohtsuki S, Soga T, Nabet B, Kaneda A. SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia. Cell Rep, 2022;41:111727. doi: 10.1016/j.celrep.2022.111727.
Inoue T*, Matsuda K*, Matsusaka K, Nakajima M, Takeno Y, Miyazaki T, Shintaku T, Yoda N, Saito T, Ikeda E, Mano Y, Shinohara K, Rahmutulla B, Fukuyo M, Kita K, Nemoto T, Kaneda A. Anti-proliferating and apoptosis-inducing activity of chemical compound FTI-6D in association with p53 in human cancer cell lines. Chem Biol Interact, 2023;369:110257. doi: 10.1016/j.cbi.2022.110257. epub 2022 Nov 11.
Kondo S, Okabe A, Nakagawa T, Matsusaka K, Fukuyo M, Rahmutulla B, Dochi H, Mizokami H, Kitagawa Y, Kurokawa T, Mima M, Endo K, Sugimoto H, Wakisaka N, Misawa K, Yoshizaki T, Kaneda A. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. BBA - Molecular Basis of Disease, 2023;1869:166598. doi: 10.1016/j.bbadis.2022.166598. epub 2022 Nov 11.
Aersilan A, Hashimoto N, Yamagata K, Yokoyama M, Nakayama A, Shi X, Nagano H, Sakuma I, Nohata N, Kinoshita T, Seki N, Rahmutulla B, Kaneda A, Zhahara SN, Gong Y, Nishimura M, Kawauchi S, Kawakami E, Tanaka T. MicroRNA-874 targets phosphomevalonate kinase and inhibits cancer cell growth via the mevalonate pathway. Sci Rep, 2022;12:18443. doi: 10.1038/s41598-022-23205-w.
Yamato A, Nagano H, Gao Y, Matsuda T, Hashimoto N, Nakayama A, Yamagata K, Yokoyama M, Gong Y, Shi X, Zhahara SN, Kono T, Taki Y, Furuki N, Nishimura M, Horiguchi K, Iwadate Y, Fukuyo M, Rahmutulla B, Kaneda A, Hasegawa Y, Kawashima Y, Ohara O, Ishikawa T, Kawakami E, Nakamura Y, Inoshita N, Yamada S, Fukuhara N, Nishioka H, Tanaka T. Proteogenomic Landscape and Clinical Characterization of GH-Producing Pituitary Adenoma. Commun Biol, 2022;5:1304. doi: 10.1038/s42003-022-04272-1.
Urabe M*, Matsusaka K*, Ushiku T, Fukuyo M, Rahmutulla B, Yamashita H, Seto Y, Fukayama M, Kaneda A. Adenocarcinoma of the stomach and esophagogastric junction with low DNA methylation show poor prognoses. Gastric Cancer, 2023;26:95-107. doi: 10.1007/s10120-022-01344-3. epub 2022 Oct 12.
Myint K, Chuang LSH, The YX, Mawan NA, Shi EJ, Mok MMH, Nuttonmanit N, Matsuo J, Li Y, Yang H, Okabe A, Kaneda A, Osato M, So JBY, Yong WP, Tan P, Yeoh KG, Ito Y. Oncofetal protein IGF2BP1 regulates 1 IQGAP3 expression to maintain stem cell potential in cancer. iScience, 2022;25(10):105194. doi: 10.1016/j.isci.2022.105194.
Iinuma T, Kiuchi M, Hirahara K, Kurita J, Kokubo K, Yagyu H, Yoneda R, Arai T, Sonobe Y, Fukuyo M, Kaneda A, Yonekura S, Nakayama T, Okamoto Y, Hanazawa T. Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion. J Allergy Clin Immunol, 2022;150(4):850-860.e5. doi: 10.1016/j.jaci.2022.06.024. epub 2022 Jul 19.
Matsumoto Y, Shinjo K, Mase S, Fukuyo M, Aoki K, Ozawa F, Yoshihara H, Goto S, Kitaori T, Ozaki Y, Takahashi S, Kaneda A, Sugiura-Ogasawara M, Kondo Y. Characteristic DNA methylation profiles of chorionic villi in recurrent miscarriage. Sci Rep, 2022 Jul 27;12(1):11673. doi: 10.1038/s41598-022-15656-y.
Yogi N, Usui G, Matsusaka K, Fukuyo M, Fujiki R, Seki M, Takano S, Abe H, Morikawa T, Ushiku T, Ohtsuka M, Kaneda A. Association of tumors having Epstein-Barr virus in surrounding lymphocytes with poor prognosis. Cancer Med, 2023;12:1122-1136. doi: 10.1002/cam4.4967. epub 2022 June 21.
Dochi H, Kondo S, Murata T, Fukuyo M, Nanbo A, Wakae K, Jiang W, Hamabe-Horiike T, Tanaka M, Nishiuchi T, Mizokami H, Moriyama-Kita M, Kobayashi E, Hirai N, Komori T, Ueno T, Nakanishi Y, Hatano M, Endo K, Sugimoto H, Wakisaka N, Juang S, Muramatsu M, Kaneda A, Yoshizaki T. Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma. Cancer Sci, 2022;113(8):2862-2877. doi: 10.1111/cas.15440. epub 2022 May 28.
Nargund AM, Xu C, Mandoli A, Okabe A, Chen GB, Huang KK, Sheng T, Yao X, Teo JMN, Sundar R, Kok YJ, See YX, Xing M, Li Z, Yong CH, Anand A, Fazreen Z, Fazreen Z, Poon LF, Ng MSW, Koh JYP, Ooi WF, Tay ST, Ong X, Tan ALK, Grabsch HI, Fullwood MJ, Teh TB, Bi X, Kaneda A, Li S, Tan P. Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer. Cancer Res, 2022;82(14):2538-2551. doi: 10.1158/0008-5472.CAN-21-2072. epub 2022 May 18.
Yamasoba D, Kimura I, Nasser H, Morioka Y, Nao N, Ito J, Uriu K, Tsuda M, Zahradnik J, Shirakawa K, Suzuki R, Kishimoto M, Kosugi Y, Kobiyama K, Hara T, Toyoda M, Tanaka YL, Butlertanaka EP, Shimizu R, Ito H, Wang L, Oda Y, Orba Y, Sasaki M, Nagata K, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Kuramochi J, Seki M, Fujiki R, Kaneda A, Shimada T, Nakada T, Sakao S, Suzuki T, Ueno T, Takaori-Kondo A, Ishii KJ, Schreiber G, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Saito A, Irie T, Tanaka S, Matsuno K, Fukuhara T, Ikeda T, Sato K, Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike, Cell, 2022 Jun; 185: 2103-2115.e19. doi: 10.1016/j.cell.2022.04.035. epub 2022 May 2.
Okabe A, Kaneda A. Hi-C analysis to identify genome-wide chromatin structural aberration in cancer. Methods Mol Biol, 2023;2519:127-140. doi:10.1007/978-1-0716-2433-3_15.
Hirasaki Y, Okabe A, Fukuyo M, Rahmutulla B, Mano Y, Seki M, Hoshii T, Namiki T, Kaneda A. Cinobufagin inhibits proliferation of acute myeloid leukaemia cells by repressing c-Myc pathway-associated genes. Chem Biol Interact, 2022 Jun; 360: 109936. doi:10.1016/j.cbi.2022.109936. epub 18 Apr 2022.
Suzuki R, Yamasoba D, Kimura I, Wang L, Kishimoto M, Ito J, Morioka Y, Nao N, Nasser H, Uriu K, Kosugi Y, Tsuda M, Orba Y, Sasaki M, Shimizu R, Kawabata R, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K; Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Ikeda T, Irie T, Matsuno K, Tanaka S, Fukuhara T, Sato K. Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant. Nature, 2022;603(7902):700-705. doi: 10.1038/s41586-022-04462-1. Epub 2022 Feb 1.
Yamada H, Takeshima H, Fujiki R, Yamashita S, Sekine S, Ando T, Hattori N, Okabe A, Yoshikawa T, Obama K, Katai H, Kaneda A, Ushijima T. ARID1A loss-of-function induces CpG island methylator phenotype. Cancer Lett, 2022 Feb; 532: 215587. doi: 10.1016/j.canlet.2022.215587. epub 2022 Feb 5.
Fujii T, Okabe A, Kaneda A. Epigenetic contribution to tumorigenesis of host cells by Epstein-Barr virus infection. Chiba Medical J, 2022 Feb; 98E: 1-7. doi:10.20776/S03035476-98E-1-P1.
Douchi D, Yamamura A, Matsuo J, Lee J-W, Nuttonmanit N, Melissa Lim YH, Suda K, Shimura M, Chen S, Pang S, Kohu K, Kaneko M, Kiyonari H, Kaneda A, Yoshida H, Taniuchi I, Osato M, Yang H, Unno M, Bok-Yan So J, Yeoh KG, Huey Chuang LS, Bae S-C, Ito Y. A point mutation R122C in RUNX3 promotes the expansion of isthmus stem cells and inhibits their differentiation in the stomach. Cell Mol Gastroenterol Hepatol, 2022 May; 13: 1317-1345. doi: 10.1016/j.jcmgh.2022.01.010. epub 2022 Jan 21.
2021
Uriu K, Kimura I, Shirakawa K, Takaori-Kondo A, Nakada T, Kaneda A, Nakagawa S, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine serum. New Engl J Med, 2021 Dec; 385:2397-2399. doi: 10.1056/NEJMc2114706. epub 2021 Nov 3.
Kitamoto T, Kuo T, Okabe A, Kaneda A, Accili D. An integrative transcriptional logic model of hepatic insulin resistance. PNAS, 2021 Nov; 118(45): e21022221183. doi: 10.1073/pnas.2102222118. epub 2021 Nov 3.
Kusakabe Y, Chiba T, Oshima M, Koide S, Rizq O, Aoyama K, Ao J, Kaneko T, Kanzaki H, Kanayama K, Maeda T, Saito T, Nakagawa R, Kobayashi K, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Nakamoto S, Yasui S, Mikata R, Muroyama R, Kanda T, Maruyama H, Kato J, Mimura N, Ma A, Jin J, Zen Y, Otsuka M, Kaneda A, Iwama A, Kato N. EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma. Sci Rep, 2021 Nov;11(1):21396. doi: 10.1038/s41598-021-00889-0.
Saito M*, Sada A*, Fukuyo M*, Aoki K*, Okumura K, Tabata Y, Chen Y, Kaneda A, Wakabayashi Y, Ohki R. PHLDA3 is an important downstream mediator of p53 in squamous cell carcinogenesis. J Invest Dermatol, 2021 Sep 27: S0022-202X(21)02271-5. doi: 10.1016/j.jid.2021.09.007. (*equal first authors)
Shinoda D, Nakajima-Takagi Y, Oshima M, Koide S, Aoyama K, Saraya A, Harada H, Rahmutulla B, Kaneda A, Yamaguchi K, Furukawa Y, Koseki H, Shimoda K, Tanaka T, Sashida G, Iwama A. Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis. Leukemia, epub 2021 Sep 8. doi: 10.1038/s41375-021-01402-2.
Kimura K, Tsukamoto S, Miyazaki K, Kawajiri-Manako C, Ishii A, Rahmutulla B, Fukuyo M, Oshima-Hasegawa N, Mitsukawa S, Takeda Y, Mimura N, Takeuchi M, Ohwada C, Iseki T, Matsusaka K, Sanada M, Yokote K, Kaneda A, Ishida T, Suzuki K, Nakaseko C, Sakaida E. Identification of Clonal Immunoglobulin λ Light-Chain Gene Rearrangements in AL Amyloidosis using Next Generation Sequencing. Exp Hematol, 2021 Sep;101-102:34-41.e4. doi: 10.1016/j.exphem.2021.08.001. epub 2021 Aug 17.
Abe H, Kunita A, Otake Y, Kanda T, Kaneda A, Ushiku T, Fukayama M. Virus–host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage. PLoS One, 2021 Sept; 16: e0256440. https://doi.org/10.1371/journal.pone.0256440.
Kageyama,T, Ikeda K, Tanaka S, Taniguchi T, Igari H, Onouchi Y, Kaneda A, Matsushita K, Hanaoka H, Nakada T, Ohtori Seiji, Yoshino I, Matsubara H, Nakayama T, Yokote K, Nakajima H. Antibody responses to BNT162b2 mRNA COVID-19 vaccine in 2,015 healthcare workers in a single tertiary referral hospital in Japan. Clin Microbiol Infect, 2021 Dec: 27(12): 1861.e1-1861.e5. doi: 10.1016/j.cmi.2021.07.042. epub 2021 Aug 8.
Mishina T, Oshima-Hasegawa N, Tsukamoto S, Fukuyo M, Kageyama H, Muto T, Mimura N, Rahmutulla B, Nagai Y, Kayamori K, Hino Y, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Tsujimura H, Iseki T, Nakaseko C, Ikeda J, Itami M, Yokote K, Ohara O, Kaneda A, Sakaida E. Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort. Brit J Haematol, 2021 Dec; 195(5): 731-742. doi: 10.1111/bjh.17765. epub 2021 Aug 10.
Lin L, Koike H, Ono T, Hayashi S, Kudo F, Kaneda A, Kagechika H, Manabe I, Nakashima T, Oishi Y. Identification of a novel KLF5-dependent program and drug development for skeletal muscle atrophy. PNAS, 2021 Aug; 118: e2102895118. doi: 10.1073/pnas.2102895118. epub 2021 Aug 23.
Maimaiti M, Sakamoto S, Sugiura M, Kanesaka M, Fujimoto A, Matsusaka K, Xu M, Ando K, Saito S, Wakai K, Imamura Y, Nakayama K, Kanai Y, Kaneda A, Ikehara Y, Ikeda JI, Anzai N, Ichikawa T. The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2. Sci Rep, 2021 Jun. 11:11478. doi: 10.1038/s41598-021-90748-9
Rii J, Sakamoto S, Sugiura M, Kanesaka M, Fujimoto A, Yamada Y, Maimaiti M, Ando K, Wakai K, Xu M, Imamura Y, Shindo N, Hirota T, Kaneda A, Kanai Y, Ikehara Y, Anzai N, Ichikawa T. Functional analysis of LAT3 in prostate cancer: its downstream target and relationship with androgen receptor. Cancer Sci, 2021 Sep; 112: 3871-3883. doi: 10.1111/cas.14991. epub 2021 May 29.
Li W, Okabe A, Usui G, Fukuyo M, Matsusaka K, Bahityar R, Mano Y, Hoshii T, Funata S, Hiura N, Fukayama M, Tan P, Ushiku T, Kaneda A. Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer. Cancer Sci, 2021 Aug; 112: 3349– 3362. doi: 10.1111/cas.14978. epub 2021 May 20
Okabe A, Kaneda A. Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer. Cancer Sci, 2021 Jun;112(6):2081-2088. doi: 10.1111/cas.14884. epub 2021 Mar 17.
Nakagawa T, Kurokawa T, Mima M, Imamoto S, Mizokami H, Kondo S, Okamoto Y, Misawa K, Hanazawa T, Kaneda A. DNA Methylation and HPV-Associated Head and Neck Cancer. Microorganisms, 2021 Apr; 9: 801. doi: 10.3390/microorganisms9040801.
Hata A, Nakajima T, Matsusaka K, Fukuyo M, Nakayama M, Morimoto J, Ito Y, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Iwata T, Matsubara H, Ohara O, Yoshino I, Kaneda A. Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis. Int J Cancer, 2021 Jun 15;148(12):3008-3018. doi: 10.1002/ijc.33499. Epub 2021 Feb 19.
Takeno Y, Kita K, Kaneda A. Cancer stratification into molecular subtypes and target therapy development. Chiba Medical J, 2021 Feb; 97E: 11-16. doi:10.20776/S03035476-97E-1-P11.
Sugiura M, Sato H, Kanesaka M, Imamura Y, Sakamoto S, Ichikawa T, Kaneda A. Epigenetic modifications in prostate cancer. Int J Urol, 2021 Feb; 28: 140-149. DOI: 10.1111/iju.14406. Epub 2020 Oct 28.
Sugiura M, Sato H, Okabe A, Fukuyo M, Mano Y, Shinohara K, Rahmutulla B, Higuchi K, Maimaiti M, Kanesaka M, Imamura Y, Furihata T, Sakamoto S, Komiya A, Anzai N, Kanai Y, Luo J, Ichikawa T, Kaneda A. Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer. Transl Oncol, 2021 Jan; 14 :100915. doi: 10.1016/j.tranon.2020.100915.
2020
Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamazaki S, Yamashita M, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A. Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche. J Exp Med, 2021 Mar 1; 218(3): e20192283. Doi: 10.1084/jem.20192283. Epub 2020 Nov 24.
Usui G, Matsusaka K, Mano Y, Urabe M, Funata S, Fukayama M, Ushiku T, Kaneda A. DNA methylation and genetic aberrations in gastric cancer. Digestion, 2021 Jan; 102: 25-32. doi: 10.1159/000511243. Epub 2020 Oct 16.
Okabe A, Huang KK, Matsusaka K, Fukuyo M, Xing M, Ong X, Hoshii T, Usui G, Seki M, Mano Y, Rahmutulla B, Kanda T, Suzuki T, Rha SY, Ushiku T, Fukayama M, Tan P, Kaneda A. Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus positive gastric adenocarcinoma. Nat Genet. 2020 Sep;52(9):919-930. doi: 10.1038/s41588-020-0665-7. Epub 2020 Jul 27.
Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka M, Isagawa T, Matsuda J, Oshima T, Matsubara T, Sugita J, Kudo F, Kaneda A, Endo Y, Nakayama T, Nagai R, Komuro I, Manabe I. A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. PNAS, 2020 Jun 23;117(25):14365-14375. doi: 10.1073/pnas.2005924117. Epub 2020 Jun 8.
Hata A, Suzuki H, Nakajima T, Fujiwara T, Shiina Y, Kaiho T, Toyoda T, Inage T, Ito T, Sakairi Y, Tamura H, Wada H, Yamada Y, Chiyo M, Matsusaka K, Fukuyo M, Shinohara K, Itoga S, Motohashi S, Matsushita K, Kaneda A, Yoshino I. Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: A comprehensive transcriptome-based analysis. PLoS One. 2020; 15(5): e0232884. epub 2020 May 8. doi: 10.1371/journal.pone.0232884.
Sata Y, Nakajima T, Fukuyo M, Matsusaka K, Hata A, Morimoto J, Rahmutulla B, Ito Y, Suzuki H, Yoshino I, Kaneda A. High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern. Cancer Sci, 2020 Jul;111(7):2588-2597. doi.org/10.1111/cas.14456. Epub 2020 May 30.
Yamamoto Y, Matsusaka K, Fukuyo M, Rahmutulla B, Matsue H, Kaneda A. Higher methylation subtype of malignant melanoma and its correlation with thicker progression and worse prognosis. Cancer Med, 9(19):7197-7204. doi: 10.1002/cam4.3127. Epub 14 May 2020.
Asakawa Y, Okabe A, Fukuyo M, Li W, Ikeda E, Mano Y, Funata S, Namba H, Fujii T, Kita K, Matsusaka K, Kaneda A. Epstein-Barr virus positive gastric cancer involves enhancer activation through ATF3. Cancer Sci, 111(5):1818-1828, 2020. Epub 2020 March 02. doi.org/10.1111/cas.14370
Ailiken G, Kitamura K, Hoshino T, Satoh M, Tanaka N, Minamoto T, Rahmutulla B, Kobayashi S, Kano M, Tanaka T, Kaneda A, Nomura F, Matsubara H, Matsushita K. Posttranscriptional regulation of BRG1 by FIRΔexon2 in gastric cancer. Oncogenesis, 2020 Feb 18;9(2):26. doi: 10.1038/s41389-020-0205-4
Nakagawa T, Matsusaka K, Misawa K, Ota S, Fukuyo M, Rahmutulla B, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Okamoto Y, Kaneda A. Stratification of HPV-associated and HPV-negative oropharyngeal squamous cell carcinomas based on DNA methylation epigenotypes. Int J Cancer, 2020 May 1;146(9):2460-2474. doi: 10.1002/ijc.32890. Epub 2020 Feb 11.
Kurokawa T, Nakagawa T, Matsusaka K, Fukuyo M, Mima M, Misawa K, Rahmutulla B, Ikeda J, Hanazawa T, Okamoto Y, Kaneda A. Establishment of epigenetic markers to predict irradiation efficacy against oropharyngeal cancer. Cancer Sci, 2020 Apr;111(4):1407-1416. doi: 10.1111/cas.14338. Epub 2020 Feb 27.
Maimaiti M, Sakamoto S, Yamada Y, Sugiura M, Rii J, Takeuchi N, Imamura Y, Furihata T, Ando K, Higuchi K, Xu M, Sazuka T, Nakamura K, Kaneda A, Kanai Y, Kyprianou N, Ikehara Y, Anzai N, Ichikawa T. Expression of L-type amino acid transporter 1 as a molecular target for prognostic and therapeutic indicators in bladder carcinoma. Sci Rep, 2020 Jan 28;10(1):1292. doi: 10.1038/s41598-020-58136-x.
2019
Fukayama M, Abe H, Kunita A, Shinozaki-Ushiku A, Matsusaka K, Ushiku T, Kaneda A. Thirty years of Epstein-Barr virus-associated gastric carcinoma. Virchows Archiv, epub 2019 Dec 13. doi: 10.1007/s00428-019-02724-4
Hokari S, Tamura Y, Kaneda A, Katsura A, Morikawa M, Murai F, Ehata S, Tsutsumi S, Ishikawa Y, Aburatani H, Kikuchi T, Miyazono K, Koinuma D. Comparative analysis of TTF-1-binding DNA regions in small cell lung cancer and nonsmall cell lung cancer. Mol Oncol, epub 2019 Nov 29. doi: 10.1002/1878-0261.12608.
Ooi WF, Nargund AM, Lim KJ, Zhang S, Xing M, Mandoli A, Lim JQ, Ho SWT, Guo Y, Yao X, Lin JS, Nandi T, Xu C, Ong X, Lee M, Tan ALK, Lam YN, Teo JX, Kaneda A, White KP, Lim WK, Rozen SG, Teh BT, Li S, Skanderup AJ, Tan P. Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma. Gut, 2019 Sep 21. doi: 10.1136/gutjnl-2018-317612. [Epub ahead of print]
Eguchi A, Nishizawa-Jotaki S, Tanabe H, Rahmutulla B, Watanabe M, Miyaso H, Todaka E, Sakurai K, Kaneda A, Mori C. An Altered DNA Methylation Status in the Human Umbilical Cord Is Correlated with Maternal Exposure to Polychlorinated Biphenyls. Int J Environ Res Public Health, 16:2786, 2019. doi:10.3390/ijerph16152786
Hata A, Nakajima T, Matsusaka K, Fukuyo M, Morimoto J, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Matsubara H, Yoshino I, Kaneda A. A low DNA methylation epigenotype in lung squamous cell carcinoma and its association with idiopathic pulmonary fibrosis and poorer prognosis. Int J Cancer, 146:388-399, 2020. doi: 10.1002/ijc.32532..
Qin R, Takayanagi S, Kondo Y, Li J, Shiga N, Nakajima M, Shinohara K, Yoda N, Suzuki T, Kaneda A, Nemoto T. Synthesis of LSD1 Inhibitor-Pyrrole-Imidazole Polyamide Conjugates for Region-Specific Alterations of Histone Modification. Heterocycles, 99: 891-905, 2019. DOI: 10.3987/COM-18-S(F)57
2018
Takane K, Fukuyo M, Matsusaka K, Ota S, Rahmutulla B, Matsushita K, Miyauchi H, Nakatani Y, Matsubara H, Kaneda A. The frequency of promoter DNA hypermethylation is decreased in colorectal neoplasms of familial adenomatous polyposis. Oncotarget, 9:32653-32666, 2018. doi: 10.18632/oncotarget.25987.
Kawajiri-Manako C, Mimura N, Fukuyo M, Namba H, Rahmutulla B, Nagao Y, Togasaki E, Shimizu R, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Yokote K, Tsuiji M, Kuwabara S, Sakaida E, Kaneda A, Nakaseko C. Clonal immunoglobulin λ light-chain gene rearrangements detected by next generation sequencing in POEMS syndrome. Am J Hematol, 93:1161-1168, 2018. doi: 10.1002/ajh.25213.
Fukayama M, Kunita A, Kaneda A. Gastritis-Infection-Cancer Sequence of Epstein-Barr Virus-Associated Gastric Cancer. Adv Exp Med Biol 1045:437-457, 2018. doi: 10.1007/978-981-10-7230-7_20.
Alagarswamy K, Shinohara K, Takayanagi S, Fukuyo M, Okabe A, Rahmutulla B, Yoda N, Qin R, Shiga N, Sugiura M, Sato H, Kita K, Suzuki T, Nemoto T, Kaneda A. Region-specific alteration of histone modification by LSD1 inhibitor conjugated with pyrrole-imidazole polyamide. Oncotarget, 9:29316-35, 2018. doi: 10.18632/oncotarget.25451.
Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T. Glucagonoma with necrolytic migratory erythema: metabolic profile and detection of biallelic inactivation of DAXX gene. J Clin Endoclinol Metab, 103:2417-23, 2018. doi: 10.1210/jc.2017-02646.
Kusano-Arai O, Iwanari H, Kudo S, Akiba H, Matsusaka K, Kaneda A, Fukayama M, Tsumoto K, Hamakubo T. Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17. Monoclon Antib Immunodiagn Immunother, 37:1-11, 2018. DOI: 10.1089/mab.2017.0043
Okabe A, Kaneda A. Epigenetic aberration at enhancer regions in gastric cancer. J Cancer Treat Diagn, 2: 31-35, 2018.
2017
Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A. Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer. Cancer Lett, 407: 21-31, 2017. doi: 10.1016/j.canlet.2017.08.008.
Okabe A, Funata S, Matsusaka K, Namba H, Fukuyo M, Rahmutulla B, Oshima M, Iwama A, Fukayama M, Kaneda A. Regulation of tumour related genes by dynamic epigenetic alteration at enhancer regions in gastric epithelial cells infected by Epstein-Barr virus. Sci Rep, 7: 7924, 2017. doi: 10.1038/s41598-017-08370-7
Funata S, Matsusaka K, Yamanaka R, Yamamoto S, Okabe A, Fukuyo M, Aburatani H, Fukayama M, Kaneda A. Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection. Oncotarget, 8:55265-55279, 2017. doi: 10.18632/oncotarget.19423.
Matsusaka K*, Funata S*, Fukuyo M, Seto Y, Aburatani H, Fukayama M, Kaneda A. Epstein-Barr virus infection induces genome-wide de novo DNA methylation in non-neoplastic gastric epithelial cells. J Pathol, 242:391-399, 2017. doi: 10.1002/path.4909. (*equal first authors)
Shiga N, Takayanagi S, Muramoto R, Murakami T, Qin R, Suzuki Y, Shinohara K, Kaneda A, Nemoto T. Synthesis of pyrrole-imidazole polyamide oligomers based on a copper-catalyzed cross-coupling strategy. Bioorg Med Chem Lett 27:2197-2200, 2017. doi: 10.1016/j.bmcl.2017.03.052.
Takane K. Akagi K. Fukuyo M. Yagi K. Takayama T. Kaneda A. DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. Cancer Med, 6:1023-1035, 2017. doi: 10.1002/cam4.1061
2016
Hasegawa N, Oshima M, Sashida G, Matsui H, Koide S, Saraya A, Wang C, Muto T, Takane K, Kaneda A, Shimoda K, Nakaseko C, Yokote K, Iwama A. Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia, 31:861-871, 2017. doi: 10.1038/leu.2016.268.
Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A. Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide. ACS Omega, 1:1164-72, 2016. doi: 10.1021/acsomega.6b00229.
Namba-Fukuyo H, Funata S, Matsusaka K, Fukuyo M, Rahmutulla B, Mano Y, Fukayama M, Aburatani H, Kaneda A. TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection. Oncotarget, 7:81512-26, 2016. doi: 10.18632/oncotarget.13130.
Matsusaka K, Ushiku T, Urabe M, Fukuyo M, Abe H, Ishikawa S, Seto Y, Aburatani H, Hamakubo T, Kaneda A, Fukayama M. Coupling CDH17 and CLDN18 markers for comprehensive membrane-targeted detection of human gastric cancer. Oncotarget, 7:64168-81, 2016. doi: 10.18632/oncotarget.11638.
Takane K, Matsusaka K, Ota S, Fukuyo M, Yue Y, Nishimura M, Abe H, Sakai E, Matsushita K, Miyauchi H, Fukayama M, Aburatani H, Nakatani Y, Takayama T, Matsubara H, Akagi K, Kaneda A. Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis. Oncotarget, 7:84003-16, 2016. doi: 10.18632/oncotarget.11510.
Funata S, Fukayama M, Kaneda A. De novo methylation in cancer. In: Encyclopedia of Life Sciences (eLS). John Wiley & Sons, Ltd: Chichester. doi: 10.1002/9780470015902.a0026465
Matsusaka K, Ishikawa S, Nakayama A, Ushiku T, Nishimoto A, Urabe M, Kaneko N, Kunita A, Kaneda A, Aburatani H, Fujishiro M, Seto Y, Fukayama M. Tumor Content Chart-Assisted HER2/CEP17 Digital PCR Analysis of Gastric Cancer Biopsy Specimens. PLoS One, 11:e0154430, 2016. doi: 10.1371/journal.pone.0154430.
Kita K, Sugita K, Sato C, Sugaya S, Kaneda, A. Extracellular Release of Annexin A2 is Enhanced upon Oxidative Stress Response via the p38 MAPK Pathway after Low-Dose X-Ray Radiation. Radiat Res, 186: 79-91, 2016. doi: 10.1667/RR14277.1.
Sakai E, Fukuyo M, Matsusaka K, Ohata K, Doi N, Takane K, Matsuhashi N, Fukushima J, Nakajima A, Kaneda A. TP53 mutation at early stage of colorectal cancer progression from two types of laterally spreading tumors. Cancer Sci, 107:820-7, 2016. doi: 10.1111/cas.12930.
Saju P, Murata-Kamiya N, Hayashi T, Senda Y, Nagase L, Noda S, Matsusaka K, Funata S, Kunita A, Urabe M, Seto Y, Fukayama M, Kaneda A, Hatakeyama M. Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV. Nat Microbiol, 1:16026, 2016. doi: 10.1038/nmicrobiol.2016.26.
Fujimoto M, Mano Y, Anai M, Yamamoto S, Fukuyo M, Aburatani H, Kaneda A. Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence. World J Biol Chem, 7:188-205, 2016. doi: 10.4331/wjbc.v7.i1.188.
Suzuki Y, Tanaka Y, Nakano S, Dodo K, Yoda N, Shinohara K, Kita K, Kaneda A, Sodeoka M, Hamada Y, Nemoto T. Platinum-Catalyzed Friedel-Crafts-Type C-H Coupling-Allylic Amination Cascade to Synthesize 3,4-Fused Tricyclic Indoles. Chemistry, 22:4418-21, 2016. doi: 10.1002/chem.201600375
Ishige T, Nishimura M, Satoh M, Fujimoto M, Fukuyo M,Semba T, Kado S, Tsuchida S, Sawai S, Matsushita K, Togawa A, Matsubara H, Kaneda A, Nomura F. Combined Secretomics and Transcriptomics Revealed Cancer-Derived GDF15 is Involved in Diffuse-Type Gastric Cancer Progression and Fibroblast Activation. Sci Rep, 6:21681, 2016. doi: 10.1038/srep21681
Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, Fukushima J, Fukayama M, Akagi K, Aburatani H, Nakajima A, Kaneda A. Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway. Int J Cancer 138: 1634-44, 2016. doi: 10.1002/ijc.29903.
Kaneda A, Nonaka A, Fujita T, Yamanaka R, Fujimoto M, Miyazono K, Aburatani H. Epigenomic regulation of Smad1 signaling during cellular senescence induced by Ras activation. Methods Mol Biol 1344:341-53, 2016. doi: 10.1007/978-1-4939-2966-5_22.
2015
Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T. Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes. Mol Cell Biol 35:3841-53, 2015. doi: 10.1128/MCB.00677-15.
Matsushita K, Kitamura K, Rahmutulla B, Tanaka N, Ishige T, Satoh M, Hoshino T, Miyagi S, Mori T, Itoga S, Shimada H, Tomonaga T, Kito M, Nakajima-Takagi Y, Kubo S, Nakaseko C, Hatano M, Miki T, Matsuo M, Fukuyo M, Kaneda A, Iwama A, Nomura F. Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. Oncotarget 6:5102-17, 2015. DOI: 10.18632/oncotarget.3244
Kaneda A, Yagi K. Quantitative DNA methylation analysis for epigenotyping of colorectal cancer. Methods Mol Biol 1238:289-99, 2015. doi: 10.1007/978-1-4939-1804-1_15.
Abe H, Kaneda A, Fukayama M. Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations. Pathobiology. 82:212-23, 2015. doi: 10.1159/000434683.
Sato T, Kita K, Sato C, Kaneda A. Hochu-ekki-to (Bu-zhong-yi-qi-tang), a herbal medicine, enhances cisplatin-induced apoptosis in HeLa cells. Mol Med Rep 2:6215-20, 2015.
〜2014
Takane K, Midorikawa Y, Yagi K, Sakai A, Aburatani H, Takayama T, Kaneda A. Aberrant promoter methylation of PPP1R3C and EFHD1 in plasma of colorectal cancer patients. Cancer Med 3:1235-45, 2014. doi: 10.1002/cam4.273.
Kaneda A, Matsusaka K, Sakai E, Funata S. DNA methylation accumulation and its predetermination of future cancer phenotypes. J Biochem 20:978-87, 2014. doi: 10.1093/jb/mvu038.
Matsusaka K, Funata S, Fukayama S, Kaneda A. DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus. World J Gastroenterol 20:3916-26, 2014. doi: 10.3748/wjg.v20.i14.3916.
Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A. Methylation epigenotypes and genetic features in colorectal laterally spreading tumors. Int J Cancer 135:1586-95, 2014. doi: 10.1002/ijc.28814.
Tanaka T, Arai M, Jiang X, Sugaya S, Kanda T, Fujii K, Kita K, Sugita K, Imazeki F, Miyashita T, Kaneda A, Yokosuka O. Downregulation of microRNA-431 by human interferon-β inhibits viability of medulloblastoma and glioblastoma cells via upregulation of SOCS6. Int J Oncol 44:1685-90, 2014. doi: 10.3892/ijo.2014.2317.
Sakai E, Nakajima A, Kaneda A. Accumulation of aberrant DNA methylation during colorectal cancer development. World J Gastroenterol 20:978-87, 2014. doi: 10.3748/wjg.v20.i4.978.
Tanaka T, Arai M, Minemura S, Oyamada A, Saito K, Jiang X, Tsuboi M, Sazuka S, Maruoka D, Matsumura T, Nakagawa T, Sugaya S, Kanda T, Katsuno T, Kita K, Kishimoto T, Imazeki F, Kaneda A, Yokosuka O. Expression level of sonic hedgehog correlates with the speed of gastric mucosa regeneration in artificial gastric ulcers. J Gastroenterol Hepatol 29:736-41, 2014. doi: 10.1111/jgh.12445
Kikuchi Y, Tsuji E, Yagi K, Matsusaka K, Tsuji S, Kurebayashi J, Ogawa T, Aburatani H, Kaneda A. Aberrantly methylated genes in human papillary thyroid cancer and correlation of their methylation to BRAF/RAS mutation. Front Genet 4:271, 2013. doi: 10.3389/fgene.2013.00271.
Sato T, Kaneda A, Tsuji S, Isagawa T, Yamamoto S, Fujita T, Yamanaka R, Tanaka Y, Nukiwa T, Marquez VE, Ishikawa Y, Ichinose M, Aburatani H. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep 3:1911, 2013. doi: 10.1038/srep01911.
Kaneda A, Matsusaka K, Aburatani H, Fukayama M. Epstein-Barr virus infection as an epigenetic driver of tumorigenesis. Cancer Res 72:3445-3450, 2012. doi: 10.1158/0008-5472.CAN-11-3919.
Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H. Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. Genome Res 22: 208-219, 2012. doi: 10.1101/gr.123109.111.
Yagi K, Takahashi H, Akagi K, Matsusaka K, Seto Y, Aburatani H, Nakajima A, Kaneda A. Intermediate methylation epigenotype and its correlation to KRAS mutation in conventional colorectal adenoma. Am J Pathol 180: 616-625, 2012. doi: 10.1016/j.ajpath.2011.10.010.
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M. Classification of Epstein-Barr virus positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res 71:7187-7197, 2011. doi: 10.1158/0008-5472.CAN-11-1349.
Kaneda A, Fujita T, Anai M, Yamamoto S, Nagae G, Morikawa M, Tsuji S, Oshima M, Miyazono K, Aburatani H. Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence. PLoS Genet 7:e1002359, 2011. doi: 10.1371/journal.pgen.1002359.
Kaneda A, Yagi K. Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes. Cancer Sci 102:18-24, 2011. doi: 10.1111/j.1349-7006.2010.01712.x.
Deng YB, Nagae G, Midorikawa Y, Yagi K, Tsutsumi S, Yamamoto S, Hasegawa K, Kokudo N, Aburatani H, Kaneda A. Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci 101:1501-10, 2010. doi: 10.1111/j.1349-7006.2010.01549.x.
Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A. Three DNA methylation epigenotypes in human colorectal cancer. Clin Cancer Res 16:21-33, 2010. doi: 10.1158/1078-0432.CCR-09-2006.
Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci USA 104:20926-31, 2007. DOI: 10.1073/pnas.0710359105
Hayashi H, Nagae G, Tsutsumi S, Kaneshiro K, Kozaki T, Kaneda A, Sugisaki H, Aburatani H. High-resolution mapping of DNA methylation in human genome using oligonucleotide tiling array. Hum Genet 120: 701-11, 2007. DOI: 10.1007/s00439-006-0254-6
Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, Arii K, Kaneda A, Tsukamoto T, Tatematsu M, Tamura G, Saito D, Sugimura T, Ichinose M, Ushijima T. High levels of aberrant DNA methylation in Helicobacterpylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res 12: 989-95, 2006. DOI: 10.1158/1078-0432.CCR-05-2096
Kaneda A, Feinberg AP. Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer Res 65: 11236-40, 2005. DOI: 10.1158/0008-5472.CAN-05-2959
Chi XZ, Yang JO, Lee KY, Ito K, Sakakura C, Li QL, Kim HR, Cha EJ, Lee YH, Kaneda A, Ushijima T, Kim WJ, Ito Y, Bae SC. RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor β-activated SMAD. Mol Cell Biol 25: 8097-107, 2005. DOI: 10.1128/MCB.25.18.8097-8107.2005
Sakatani T*, Kaneda A*, Iacobuzio-Donahue CA*, Carter MG, Witzel SD, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307: 1976-8, 2005. DOI: 10.1126/science.1108080 (*equal first authors)
Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, and Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res 15:15-20, 2005.
Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, Takato T, Nakagawara A, Ushijima T. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res 65: 828-34, 2005.
Ushijima T, Watanabe N, Shimizu K, Miyamoto K, Sugimura T, Kaneda, A. Decreased fidelity in replicating CpG methylation patterns in cancer cells. Cancer Res 65: 11-17, 2005.
Okochi-Takada E, Ichimura S, Kaneda A, Sugimura T, Ushijima, T. Establishment of a detection system for demethylating agents using an endogenous promoter CpG island. Mutat Res 568: 187-94, 2004.
Kaneda A, Wakazono K, Tsukamoto T, Watanabe N, Yagi Y, Tatematsu M, Kaminishi M, Sugimura T, Ushijima, T. Lysyl Oxidase is a tumor-suppressor gene inactivated by methylation and loss of heterozygosity in human gastric cancers. Cancer Res 64: 6410-15, 2004.
Kaneda A, Kaminishi M, Sugimura T, Ushijima T. Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer Lett 212: 203-10, 2004.
Kaneda A, Tsukamoto T, Takamura-Enya T, Watanabe N, Kaminishi M, Sugimura T, Tatematsu M, Ushijima T. Frequent hypomethylation in multiple promoter CpG islands is associated with global hypomethylation, but not with frequent promoter hypermethylation. Cancer Sci 95: 58-64, 2004.
Ushijima T, Watanabe N, Okochi E, Kaneda A, Sugimura T, Miyamoto K. Fidelity of the methylation pattern and its variation in the genome. Genome Res 13: 868-74, 2003.
Kaneda A, Takai D, Kaminishi M, Okochi E, Ushijima T. Methylation-sensitive-representational difference analysis and its application to cancer research. Ann N Y Acad Sci 983: 131-41, 2003.
Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima, T. Identification of silencing of nine genes in human gastric cancers. Cancer Res 62: 6645-50, 2002.
Abe M, Okochi E, Kuramoto T, Kaneda A, Takato T, Sugimura T, Ushijima T. Cloning of the 5' Upstream Region of the Rat p16 Gene and Its Role in Silencing. Jpn J Cancer Res 93: 1100-6, 2002.
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