PUBLICATIONS　/　業　績

[2023] [2022] [2021] [2020] [2019] [2018] [2017] [2016] [2015] [2014] [2013]

２０２３年

• Koyama-Nasu, R., Kimura, M.Y., Kiuchi, M., Aoki, A., Wang, Y., Mita, Y., Hasegawa, I., Endo, Y., Onodera, A., Hirahara, K., Motohashi, S., Nakayama, T.: CD69 imposes tumor-specific CD8+ T cell fate in tumor-draining lymph nodes. Cancer Immunol. Res. 11(8):1085-1099(2023).

• Kobayashi, H., Kimura, M.Y., Hasegawa, I., Suganuma, E., Ikehara, Y., Azuma, K., Ito, T., Ebata, R., Kurashima, Y., Kawasaki, Y., Shiko, Y., Saito, N., Iwase, H., Lee, Y., Noval Rivas, M., Arditi, M., Zuka, M., Hamada, H.*, and Nakayama, T.: Increased Myosin light chain 9 expression during Kawasaki disease vasculitis. Front. Immunol. 13:1036672(2023).

２０２２年

• Koyama-Nasu, R., Wang, Y., Hasegawa, I., Endo, Y., Nakayama, T. and Kimura, M. Y.: The cellular and molecular basis of CD69 function in anti-tumor immunity. Int. Immunol.: dxac024(2022).

２０２１年

• Nakayama T, Hirahara K, Kimura MY, Iwamura C, Kiuchi M, Kokubo K, Onodera A, Hashimoto K, Motohashi S.: CD4+ T cells in inflammatory diseases: pathogenic T- helper cells and the CD69–Myl9 system. Int. Immunol. 33(12):699-704(2021).

• Sarkar MH, Yagi R, Endo Y, Koyama-Nasu R, Wang Y, Hasegawa I, Ito T, Junttila IS, Zhu J, Kimura MY, Nakayama T.：IFNγ suppresses the expression of GFI1 and thereby inhibits Th2 cell proliferation. PLoS ONE 16(11): e0260204(2021).

• Yokoyama, M., Kimura, M.Y., Ito, T., Hayashizaki, K., Endo, Y., Wang, Y., Yagi, R., Nakagawa, T., Kato, N., Matsubara, H. and Nakayama, T.: Myosin light chain 9/12 regulates the pathogenesis of inflammatory bowel disease. Front. Immunol. 11: 594297(2021). 

２０２０年

• Suzuki, A.S., Yagi, R., Kimura, M.Y., Iwamura, C., Shinoda, K., Onodera, A., Hirahara, K., Tumes, D.J., Koyama-Nasu, R., Lismaa, S.E., Graham, R.M., Motohashi, S. and Nakayama, T.: Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front. Immunol. 11:1536(2020).

• Aoki, T., Takami, M., Takatani, T., Motoyoshi, K., Ishii, A., Hara, A., Toyoda, T., Okada, R., Hino, M., Koyama-Nasu, R., Kiuchi, M., Hirahara, K., Kimura, M.Y., Nakayama, T., Shimojo, N., and Motohashi, S.: Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner. Cancer Sci. 111(7):2223-2233(2020).

• Angelou, C.C., Wells, A.C., Vijayaraghavan, J., Dougan, C.E., Lawlor, R., Iverson, E., Lazarevic, V., Kimura, M.Y., Peyton, S.R., Minter, L.M., Osborne, B.A., Pobezinskaya, E.L., *Pobezinsky, L.A.: Differentiation of Pathogenic Th17 Cells is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis. Front. Immunol. 17;10:3125(2020).

２０１９年

• Tumes, D., Hirahara, K., Papadopoulos, M., Shinoda, K., Onodera, A., Kumagai, J., Ho Yip, K., Pant, H., Kokubo, K., Kiuchi, M., Aoki, A., Obata-Ninomiya, K., Tokoyoda, K., Endo, Y., Kimura, M.Y. and *Nakayama, T.: Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology. J. Allergy Clin. Immunol.144(2):549-560.e10(2019).

• Pobezinskaya, E.L., Wells, A.C., Angelou, C.C., Fagerberg, E., Aral, E., Iverson, E., Kimura, M.Y. and Pobezinsky, L.A.: Survival of naïve T cells requires the expression of let-7 miRNAs. Front. Immunol. 3;10:955(2019).

• Kimura, M.Y., Koyama-Nasu, R., Yagi, R. and Nakayama, T.: A new therapeutic target: the CD69-Myl9 system in immune responses. Semin. Immunopathol. 41(3):349-358(2019). 

２０１８年

• Mita, Y., Kimura, M.Y., Hayashizaki, K., Koyama-Nasu, R., Ito, T., Motohashi, S., Okamoto, Y. and Nakayama, T.: Crucial role of CD69 in anti-tumor immunity through regulating the exhaustion of tumor-infiltrating T cells. Int. Immunol. dxy050(2018).
   
• Kimura, M.Y., Igi, A., Hayashizaki, K., Mita, Y., Shinzawa, M., Kadakia, T., Endo, Y., Ogawa, S., Yagi, R., Motohashi, S., Singer, A., and Nakayama, T.: CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation. Nat. Commun. 9: 3749(2018). 

２０１７年

• Kimura, M.Y., Hayashizaki, K., Tokoyoda, K., Takamura, S., Motohashi, S. and Nakayama, T.: Crucial role for CD69 in allergic inflammatory responses. Immunol. Rev. 278:87-100(2017). 

２０１６年

• Hayashizaki, K., Kimura, M.Y., Tokoyoda. K., Hosokawa, H., Shinoda, K., Hirahara, K., Ichikawa, T., Onodera, A., Hanazawa, A., Iwamura, C., Kakuta, J., Muramoto, K., Motohashi, S., Tumes, D.J., Iinuma, T., Yamamoto, H., Ikehara, Y., Okamoto, Y. and Nakayama, T.: Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci Immunol. 1:eaaf9154(2016).

• Kimura, M.Y., Thomas, J., Tai, X., Cuinter, T.I., Shinzawa, M., Etzensperger, R., Li, Z., Love, P., Nakayama, T. and Singer, A.: Timing and duration of MHC I positive selection signals are adjusted in the thymus to prevent lineage errors. Nat. Immunol, 17:1415-23(2016). 

２０１４年

• Luckey M., Kimura M.Y., Waickman AT., Feigenbaum L., Singer A and Park JH.: The transcription factor ThPOK suppresses Runx3 and imposes CD4 lineage fate by inducing Suppressors Of Cytokine Signaling, Nat. Immunol, 15(7):638-45(2014). 

２０１３年

• Kimura, M.Y., Pobezinsky, L.A., Guinter, T.I., Thomas, J., Adams, A., Park, J.H., Tai, X. and Singer, A.; IL-7 signaling must be intermittent, not continuous, during CD8+ T cell homeostasis to promote cell survival instead of cell death. Nat. Immunol. 14:143-151(2013).