Publication

  1. Zhang Z., Tanaka I., Nakahashi-Ouchida R., Ernst P.B., Kiyono H., Kurashima Y. Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity. 『Seminars in immunopathology』 doi: 10.1007/s00281-023-00999-z. 2024.
  2. Kan-O K., Noda T., Ogata H., Masaki K., Nishioka Y., Myojin T., Adachi T., Morita H., Imamura T., Tamari M., Kainuma K., ENGAGE NDB Task Force . Insights from the trends of omalizumab and mepolizumab utilization in patients with asthma: A population-based cohort study using the National Database in Japan. 『Respiratory investigation』 62(1):113-120 doi: 10.1016/j.resinv.2023.11.003. 2023.
  3. Akasaki Y., Iwagami M., Sung J., Nagino K., Adachi T., Morita H., Tamari M., Kainuma K., Kan-O K., Ogata H., Sakashita M., Futamura M., Kurashima Y, Nakajima S., Masaki K., Ogawa Y., Sato S., Miyagawa A., Midorikawa‐Inomata A., Fujimoto K., Okumura Y., Fujio K., Huang T., Hirosawa K., Morooka Y., Nakao S., Murakami A., Kobayashi H., Inomata T. Impact of COVID‐19 on care‐seeking patterns for hay fever in Japan: A retrospective claims database cohort study. 『Allergy』 doi: 10.1111/all.15947. 2023.
  4. Umemoto S., Nakahashi-Ouchida R., Yuki Y., Kurokawa S., Machita T., Uchida Y., Mori H., Yamanoue T., Shibata T., Sawada S., Ishige K., Hirano T., Fujihashi K., Akiyoshi K., Kurashima Y, Tokuhara D., Ernst P.B., Suzuki M., Kiyono H. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. 『NPJ vaccines』 8(1):106. doi: 10.1038/s41541-023-00700-3. 2023.
  5. Nakahashi-Ouchida R., Fujihashi K., Kurashima Y., Yuki Y., Kiyono H. 「Nasal vaccines: solutions for respiratory infectious diseases.」『Trends Mol Med.』2022: S1471-4914(22)00274-X. doi: 10.1016/j.molmed.2022.10.009.
  6. Zhang Z., Ernst P.B., Kiyono H., Kurashima Y.「Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.」『Front Immunol.』2022:13:937120. doi: 10.3389/fimmu.2022.937120. (Corresponding author)
  7. Zhang Z, Tanaka I, Pan Z, Ernst PB, Kiyono H, Kurashima Y.「Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas-intestinal barrier axis.」『Eur J Immunol. 』2022: 52(7):1035-1046. doi: 10.1002/eji.202149532. (Corresponding author)
  8. Zhang Z., and Kurashima Y.「Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation」『Cells』10(7):1615, 2021. doi: 10.3390/cells10071615. (Corresponding author)
  9. Sato S., Kainuma K., Noda T., Ebisawa M., Futamura M., Imamura T., Miyagawa A., Nakajima S., Ogawa Y., Inomata T, Kan-O K., Kurashima Y, Masaki K., Myojin T., Nishioka Y., Sakashita M, Tamari M., Morita H., Adachi T.「Evaluation of adrenaline auto-injector prescription profiles: A population-based, retrospective cohort study within the National Insurance Claims Database of Japan. 」『Allergol. Int.』2022 Mar 20;S1323-8930(22)00009-0. doi: 10.1016/j.alit.2022.02.002.
  10. Adachi T., Ogawa Y., Fukushi T., Ito K., Koizumi A., Shirabe M., Toriya M, Hirako J., Inomata T, Masaki K, Sasano R, Sato S, Kainuma K, Futamura M, Kan-O K., Kurashima Y, Nakajima S., Sakashita M., Morita H., Iwamoto A., Nishima S., Tamari M, Iizuka H.「Research impact analysis of international funding agencies in the realm of allergy and immunology」『Allergy』2022 in press doi: 10.1111/all.15249.
  11. Kamioka M., Goto Y., Nakamura K., Yokoi Y., Sugimoto R., Ohira S., Kurashima Y., Umemoto S., Sato S., Kunisawa J., Takahashi Y., Domino S.E., Renauld J.C., Nakae S., Iwakura Y., Ernst P.B., Ayabe T., Kiyono H.「Intestinal commensal microbiota and cytokines regulate Fut2 + Paneth cells for gut defense」『Proc Natl Acad Sci USA』119(3) e2115230119, 2022.
  12. Zhang Z., and Kurashima Y.「Two sides of the coin: Mast cells as a key regulator of allergy and acute/chronic inflammation」『Cells』10(7):1615, 2021. doi: 10.3390/cells10071615. (Corresponding author)
  13. Kurashima Y., Kigoshi T., Murasaki S., Arai F., Shimada K., Seki N., Kim Y.G., Hase K., Ohno H., Kawano K., Ashida H., Suzuki T, Morimoto M., Saito Y., Sasou A., Goda Y., Yuki Y., Inagaki Y., Iijima H., Suda W., Hattori M., Kiyono H.「Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation」『Nat. Commun.』12(1) 1067 - 1067. 2021. (Corresponding author)
  14. Takasato Y., Kurashima Y., Kiuchi M., Hirahara K., Murasaki S., Arai F., Izawa K., Kaitani A., Shimada K., Saito Y., Toyoshima S., Nakamura M., Fujisawa K., Okayama Y., Kunisawa J., Kubo M., Takemura N., Uematsu S., Akira S., Kitaura J., Takahashi T., Nakayama T., Kiyono H.「Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy」『Mucosal Immunol.』doi: 10.1038/s41385-020-00358-3. 2020. (Corresponding author)
  15. Matsumura S., Kurashima Y., Murasaki S., Morimoto M., Arai F., Saito Y., Katayama N., Kim D., Inagaki Y., Kudo T., Ernst P., Shimizu T., Kiyono H.「Stratified layer analysis reveals intrinsic leptin stimulates cryptal mesenchymal cells for controlling mucosal inflammation」『Sci. Rep.』2020 10(1):18351. doi: 10.1038/s41598-020-75186-3. 2020. (Corresponding author)
  16. Takahashi I., Hosomi K., Nagatake T., Tobou H., Yamamoto D., Hayashi I., Kurashima Y., Sato S., Shibata N., Goto Y., Maruyama F., Nakagawa I., Kuwae A., Abe A., Kunisawa J., Kiyono H.「Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia」『Int. Immunol.』doi: 10.1093/intimm/dxz071. 2019.
  17. Joo S., Suwanto A., Sato A., Nakahashi-Ouchida R., Mori H. Uchida Y., Sato S., Kurashima Y.,Yuki Y., Fujihashi K., Kawaguchi Y., Kiyono H. 「A role for the CCR5–CCL5 interaction in the preferential migration of HSV-2-specific effector cells to the vaginal mucosa upon nasal immunization」『Mucosal Immunol.』12(6):1391-1403. doi: 10.1038/s41385-019-0203-z. 2019.
  18. Nishida K., Hasegawa A., Yamasaki S., Uchida R., Ohashi W.,Kurashima Y.,Kunisawa J., Kimura S., Iwanaga T., Watarai H., Hase S., Ogura H., Nakayama M., Kashiwakura J., Okayama Y., Kubo M., Ohara O., Kiyono H., Koseki H., Murakami M., Hirano T. 「Mast cells play role in wound healing through the ZnT2 / GPR39 / IL-6 axis」『Sci. Rep.』25;9(1):10842. doi: 10.1038/s41598-019-47132-5. 2019.
  19. Kurashima Y.,Tokuhara D., Kamioka M., Inagaki Y., Kiyono H.「Intrinsic control of surface immune and epithelial homeostasis by tissue-resident gut stromal cells」『Front. Immunol.』19; 10:1281. doi: 10.3389/fimmu.2019.01281., 2019. (Corresponding author)
  20. Hashizume-Takizawa T., Shibata N., Kurashima Y.,Kiyono H., Kurita-Ochiai T., Fujihashi K.「Distinct roles for Peyer’s Patch B Cells for induction of antigen-specific IgA antibody responses in mice administered pral recombinant Salmonella.」『Int. Immunol.』doi: 10.1093/intimm/dxz029., 2019.
  21. Tokuhara D., Kurashima Y., Kamioka M., Nakayama T., Ernst P., Kiyono H.「A comprehensive understanding of the gut mucosal immune system in allergic inflammation」『Allergol. Int.』68(1):17-25. doi: 10.1016/j.alit.2018.09.004., 2019.
  22. Inami A., Kiyono H., Kurashima Y.「ATP as a Pathophysiologic Mediator of Bacteria-Host Crosstalk in the Gastrointestinal Tract」『Int. J. Mol. Sci.』19(8). pii: E2371. doi: 10.3390/ijms19082371, 2018. (Corresponding author)
  23. Takemura N., Kurashima Y., Mori Y., Okada K., Ogino T., Osawa H., Matsuno H., Aayam L., Kaneto S., Park EJ., Sato S., Matsunaga K., Tamura Y., Ouchi Y., Kumagai Y., Kobayashi D., Suzuki Y., Yoshioka Y., Nishimura J., Mori M., Ishii KJ., Rothenberg ME., Kiyono H., Akira S., Uematsu S.「Eosinophil depletion suppresses radiation-induced small intestinal fibrosis」『Sci .Transl. Med.』10(429). pii: eaan0333. doi: 10.1126/scitranslmed.aan0333, 2018.
  24. Takahashi Y., Sato S., Kurashima Y., Yamamoto T., Kurokawa S., Yuki Y., Takemura N., Uematsu S., Lai CY., Otsu M., Matsuno H., Osawa H., Mizushima T., Nishimura J., Hayashi M., Yamaguchi T., Kiyono H.「A refined culture system for human induced pluripotent stem cell-derived intestinal epithelial organoids」『Stem Cell Reports.』10(1):314-328. doi: 10.1016/j.stemcr.2017.11.004, 2018.
  25. Takahashi Y., Sato S., Kurashima Y.,Lai CY., Otsu M., Hayashi M.,Yamagushi T., Kiyono H.,「Reciprocal inflammatory Signaling between intestinal epithelial cells and adipocytes in the absence of immune cells」『EBioMedicine.』23: 34-45 doi:10.1016/j.ebiom.2017.07.027.2017.
  26. Kurashima Y.,Yamamoto D., Nelson S., Uematsu S., Ernst PB., Nakayama T., Kiyono H.「Mucosal mesenchymal cells: Secondary barrier and peripheral educator for the gut immune system」『Front. Immunol.』8:1787. doi: 10.3389/fimmu.2017.01787. eCollection 2017.
  27. Shimokawa C., Kanaya T., Hachisuka M., Ishiwata K., Hisaeda H., Kurashima Y., Kiyono H., Yoshimoto T., Kaisho T., Ohno H.「Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of Helminth infections」『Immunity』46(5):863-874, 2017.
  28. Toyoshima S., Wakamatsu E., Ishida, Y. Obata Y., Kurashima Y., Kiyono H., and Abe R.「The spleen is the site where mast cells are induced in the development of food allergy」『Int. Immunol.』29(1):31-45, 2017.
  29. Furuta Y., Tsai S.H., Kinoshita M., Fujimoto K., Okumura R., Umemoto E., Kurashima Y. Kiyono H., Kayama H., and Takeda K. 「E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine」『PLoS ONE』12(2):e0172509, 2017.
  30. Kurashima Y., and Kiyono H., 「Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing」『Annual Review Immunology』35:119-147, 2017.
  31. Joo S., Fukuyama Y., Park EJ., Yuki Y., Kurashima Y., Ouchida R., Ziegler SF., and Kiyono H.「Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response」『Mucosal Immunol.』10(4):901-911, 2017.
  32. Nelson S., Kiyono H., and Kurashima Y. 「Epithelial extracellular ATP: an initiator of immunity to parasitic infections」『Immunology and Cell Biology』95(2):117-118, 2016
  33. Wakita D., Kurashima Y., Crother T., Rivas M.N., Lee Y., Chen S., Fury W., Bai Y., Wagner S., Li D., Lehman T., Fishbein M., Hoffman H., Shah P., Shimada K., and Arditi M. 「The Role of IL-1 signaling in a mouse model of Kawasaki Disease-associated Abdominal Aortic Aneurysm」『Arteriosclerosis, Thrombosis, and Vascular Biology』36(5):886-97. doi: 10.1161/ATVBAHA.115.307072, 2016.
  34. Goto Y, Kurashima Y., and Kiyono H. 「The gut microbiota and inflammatory bowel disease」『Curr. Opin. Rheumatol.』 (4):388-96. doi: 10.1097/BOR.0000000000000192, 2015.
  35. Kunisawa J., Arita M., Hayasaka T., Harada T, Iwamoto R., Nagasawa R., Shikata S., Nagatake T., Suzuki H., Hashimoto E., Kurashima Y., Suzuki Y., Arai H., Setou M., and Kiyono H.「Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicostetraenoic acid in the gut」『Scientific Report』5:9750. doi: 10.1038/srep09750, 2015.
  36. Kurashima Y., Kiyono H., and Kunisawa J. 「Pathophysiological role of extracellular purinergic mediators in the control of intestinal inflammation」『Mediators of Inflammation』427125. doi: 10.1155/2015/427125, 2015.
  37. Tsai S.H., Kinoshita M., Kusu T., Kayama H., Okumura R., Ikeda K., Shimada Y., Takeda A., Yoshikawa S., Obata-Ninomiya K., Kurashima Y., Sato S., Umemoto E., Kiyono H., Karasuyama H., and Takeda K. 「The ectoenzyme E-NPP3 negatively regulates ATP-dependent chronic allergic responses by basophils and mast cells」『Immunity』42(2):279-293, 2015.
  38. Kishida K., Kohyama M., Kurashima Y., Kogure Y., Wang J., Hirayasu K., Suenaga T., Kiyono H., Kunisawa J., and Arase H.　 「Negative regulation of DSS-induced experimental colitis by PILRα」『Int. Immunol.』6, 307-314, 2015.
  39. Nakajima-Adachi H., Kikuchi A., Fujimura Y., Shibahara K., Makino T., Goseki-Sone M., Kihara-Fujioka M., Nochi T., Kurashima Y., Igarashi O., Yamamoto M., Kunisawa J., Toda M., Kaminogawa S., Sato R., Kiyono H., and Hachimura S. 「Peyer’s patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy」『PLoS ONE』9(10): e107492, 2014.
  40. Kurashima Y., Amiya T., Fujisawa K., Shibata N., Suzuki Y., Kogure y., Hashimoto E., Otsuka A., Kabashima K., Sato S., Sato T., Kubo M., Akira S., Miyake K., Kunisawa J., and Kiyono H.「Skin-barrier homeostasis through Cyp26b1-mediated inhibition of ATP-dependent mast-cell activation by fibroblasts」『Immunity』40(4):530-541, 2014.
  41. Kurashima Y., and Kiyono H. 「New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development」『Exp. Mol. Med.』46:e83.doi: 10.1038/emm, 2014.
  42. Kurashima Y., Goto Y., and Kiyono H.「Mucosal innate immune cells regulate both gut homeostasis and intestinal inflammation」『Eur. J. Immunol.』43 (12):3108-15, 2013.
  43. Kunisawa J., Gohda M., Hashimoto E., Ishikawa I., Higuchi M., Suzuki Y., Goto Y., Panea C., Ivanov I.I., Sumiya R., Aayam L., Wake T., Tajiri S., Kurashima Y., Shikata S., Akira S., Takeda K., and Kiyono H. 「Microbe-dependent CD11b+ IgA+ plasma cells mediate robust early-phase intestinal IgA responses in mice」『Nat. Commun.』4:1772. doi: 10.1038/ncomms2718, 2013.
  44. Kurashima Y., Amiya T., Nochi T., Fujisawa K., Haraguchi T., Iba H., Tsutsui H., Sato S., Nakajima S., Iijima H., Kubo M., Kunisawa J., Kiyono H.「 Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors」『Nat. Commun.』 3:1034. doi: 10.1038/ncomms2023, 2012.
  45. Tanaka S., Saito Y., Kunisawa J., Kurashima Y., Wake T., Suzuki N., Shultz L.D., Kiyono H., Ishikawa F.「Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice」『J. Immunol.』188 :6145-6155, 2011.
  46. Kunisawa J., Kurashima Y., and Kiyono H.「Gut-associated lymphoid tissues for the development of oral vaccines」『Adv. Drug Deliv. Rev.』64:523-530, 2011.
  47. Gohda M., Kunisawa J., Miura F., Kagiyama Y., Kurashima Y., Higuchi M., Ishikawa I., Ogahara I., and Kiyono H.「Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses」『J. Immunol.』180: 8, 5335-5343, 2008.
  48. Kunisawa J., Gohda M., Kurashima Y., Ishikawa I., Higuchi M., and Kiyono H.「Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells」『Blood』111: 9, 4646-4652, 2008.
  49. Kurashima Y., Kunisawa J., Higuchi M., Gohda M., Ishikawa I., Shimizu M., Takayama N., and Kiyono H.「Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy」『J. Immunol.』179: 1577–1585, 2007.
  50. Kunisawa J., Kurashima Y., Gohda M., Higuchi M., Ishikawa I., Miura F., Ogahara I., and Kiyono H.「Sphingosine 1-phosphate regulates peritoneal B cell trafficking for subsequent intestinal IgA production」『Blood』109: 3749-3756, 2007.
  51. Kunisawa J., Kurashima Y., Higuchi M., Gohda M., Ishikawa I., Ogahara I, Kim N.J., Shimizu M., and Kiyono H.「Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium」『J. Exp. Med.』204: 10, 2335-2348, 2007.