Research Achievements

Issei Komuro

2012 | 2011 | 2010 | 2009 | 2008 |
| Papers| International Conferences |

Papers

Kadohira T‚ Kobayashi Y‚ Niitsuma Y‚ Imamaki M‚ Komuro I.   Global ST-segment elevation associated with impending cardiac rupture during diagnostic cardiac catheterization.
Int Heart J.  2009;  50   (4):   539-542


Sugimoto K‚ Kobayashi Y‚ Kuroda N‚ Komuro I.   Cost analysis of sirolimus-eluting stents in the Japanese health insurance system.
Int Heart J  2009;  50   (6):   723-730


Asano T‚ Kobayashi Y‚ Fukushima K‚ Iwata Y‚ Kitahara H‚ Ishio N‚ Nakayama T‚ Kuroda N‚ Komuro I.   Effect of balloon inflation time on expansion of sirolimus-eluting stent.
Heart Vessels  2009;  24   (5):   335-339


Saito R‚ Kaneko E‚ Tanaka Y‚ Honda K‚ Matsuda T‚ Baba A‚ Komuro I‚ Kita S‚ Iwamoto T‚ Takano Y.   Involvement of Na+/Ca2+ exchanger in pentylenetetrazol-induced convulsion by use of Na+/Ca2+ exchanger knockout mice.
Biol Pharm Bull.  2009;  32   (11):   1928-1930


Wakatsuki Y‚ Funabashi N‚ Mikami Y‚ Shiina Y‚ Kawakubo M‚ Takahashi M‚ Yajima R‚ Uehara M‚ Takaoka H‚ Komuro I.   Left atrial compensatory function in subjects with early stage primary hypertension assessed by using left atrial volumetric emptying fraction acquired by transthoracic echocardiography.
Int J Cardiol.  2009;  136   (3):   363-367


Shiina Y‚ Funabashi N‚ Lee K‚ Daimon M‚ Sekine T‚ Kawakubo M‚ Takahashi M‚ Yajima R‚ Tanabe N‚ Kuriyama T‚ Komuro I.   Right atrium contractility and right ventricular diastolic function assessed by pulsed Tissue Doppler Imaging can predict brain natriuretic peptide in adults with acquired pulmonary hypertension.
Int J Cardiol.  2009;  135   (1):   53-59


Takano H‚ Komuro I.   Peroxisome proliferator-activated receptor gamma and cardiovascular diseases.
Circ J.  2009;  73   (2):   214-220


Ichimoto E‚ Jo K‚ Kobayashi Y‚ Inoue T‚ Nakamura Y‚ Kuroda N‚ Miyazaki A‚ Komuro I.   Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction.
Circ J.  2009;  73   (9):   1669-1673


Tamura A‚ Ogura T‚ Uemura H‚ Reien Y‚ Kishimoto T‚ Nagai T‚ Komuro I‚ Miyazaki M‚ Nakaya H.   Effects of antiarrhythmic drugs on the hyperpolarization-activated cyclic nucleotide-gated channel current.
J Pharmacol Sci.  2009;  110   (2):   150-159


Mikami Y‚ Sakuma H‚ Nagata M‚ Ishida M‚ Kurita T‚ Komuro I‚ Ito M.   Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction.
AJR Am J Roentgenol.  2009;  193   (4):   W321-326


Inokuchi Y‚ Shimazawa M‚ Nakajima Y‚ Komuro I‚ Matsuda T‚ Baba A‚ Araie M‚ Kita S‚ Iwamoto T‚ Hara H.   A Na+/Ca2+ exchanger isoform‚ NCX1‚ is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion.
J Neurosci Res.  2009;  87   (4):   906-917


Shiina Y‚ Funabashi N‚ Lee K‚ Murayama T‚ Nakamura K‚ Wakatsuki Y‚ Daimon M‚ Komuro I.   Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation‚ as compared with non-flavonoid white chocolate‚ by transthoracic Doppler echocardiography in healthy adults.
Int J Cardiol.  2009;  131   (3):   424-429


Kawata T‚ Daimon M‚ Hasegawa R‚ Teramoto K‚ Toyoda T‚ Sekine T‚ Yamamoto K‚ Uchida D‚ Himi T‚ Yoshida K‚ Komuro I.   Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.
Int J Cardiol.  2009;  132   (2):   286-288


Ogihara T‚ Kikuchi K‚ Matsuoka H‚ Fujita T‚ Higaki J‚ Horiuchi M‚ Imai Y‚ Imaizumi T‚ Ito S‚ Iwao H‚ Kario K‚ Kawano Y‚ Kim-Mitsuyama S‚ Kimura G‚ Matsubara H‚ Matsuura H‚ Naruse M‚ Saito I‚ Shimada K‚ Shimamoto K‚ Suzuki H‚ Takishita S‚ Tanahashi N‚ Tsuchihashi T‚ Uchiyama M‚ Ueda S‚ Ueshima H‚ Umemura S‚ Ishimitsu T‚ Rakugi H; Japanese Society of Hypertension Committee.   The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009).
Hypertens Res.  2009;  32   (1):   3-107


Akazawa H‚ Yasuda N‚ Komuro I.   Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor.
Mol Cell Endocrinol.  2009;  302   (2):   140-147


Ikeda H‚ Shiojima I‚ Ozasa Y‚ Yoshida M‚ Holzenberger M‚ Kahn CR‚ Walsh K‚ Igarashi T‚ Abel ED‚ Komuro I.   Interaction of myocardial insulin receptor and IGF receptor signaling in exercise-induced cardiac hypertrophy.
J Mol Cell Cardiol.  2009;  47   (5):   664-675


Ito K‚ Akazawa H‚ Tamagawa M‚ Furukawa K‚ Ogawa W‚ Yasuda N‚ Kudo Y‚ Liao CH‚ Yamamoto R‚ Sato T‚ Molkentin JD‚ Kasuga M‚ Noda T‚ Nakaya H‚ Komuro I.   PDK1 coordinates survival pathways and beta-adrenergic response in the heart.
Proc Natl Acd Sci U S A.  2009;  106   (21):   8689-8694


Matsuura K‚ Honda A‚ Nagai T‚ Fukushima N‚ Iwanaga K‚ Tokunaga M‚ Shimizu T‚ Okano T‚ Kasanuki H‚ Hagiwara N‚ Komuro I.   Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice.
J Clin Invest.  2009;  119   (8):   2204-2217


Minamino T‚ Orimo M‚ Shimizu I‚ Kunieda T‚ Yokoyama M‚ Ito T‚ Nojima A‚ Nabetani A‚ Oike Y‚ Matsubara H‚ Ishikawa F‚ Komuro I.   A crucial role for adipose tissue p53 in the regulation of insulin resistance.
Nat Med  2009;  15   (9):   1082-1087


Yoshida M‚ Shiojima I‚ Ikeda H‚ Komuro I.   Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity
J. Mole. Cell. Cardiol.  2009;  47   (5):   698-705


Qin Y‚ Yasuda N‚ Akazawa H‚ Ito K‚ Kudo Y‚ Liao CH‚ Yamamoto R‚ Miura SI‚ Saku K‚ Komuro I.   Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation.
Hypertens Res.  2009;  32   (10):   875-883


Otsuka K‚ Terasaki F‚ Ikemoto M‚ Fujita S‚ Tsukada B‚ Katashima T‚ Kanzaki Y‚ Sohmiya K‚ Kono T‚ Toko H‚ Fujita M‚ Kitaura Y.   Suppression of inflammation in rat autoimmune myocarditis by S100A8/A9 through modulation of the proinflammatory cytokine network.
Eur J Heart Fail  2009;  11   (3):   229-237


Kayama Y‚ Minamino T‚ Toko H‚ Sakamoto M‚ Shimizu I‚ Takahashi H‚ Okada S‚ Tateno K‚ Moriya J‚ Yokoyama M‚ Nojima A‚ Yoshimura M‚ Egashira K‚ Aburatani H‚ Komuro I.   Cardiac 12/15 lipoxygenase-induced inflammation is involved in heart failure
J Exp Med.  2009;  206   (7):   1565-1574


Kitahara H‚ Kobayashi Y‚ Takebayashi H‚ Fujimoto Y‚ Nakamura Y‚ Kuroda N‚ Himi T‚ Miyazaki A‚ Haruta S‚ Komuro I.   Re-restenosis and target lesion revascularization after treatment of sirolimus-eluting stent restenosis.
Circ J.  2009;  73   (5):   867-871


Takano H‚ Komuro I.   G-CSF therapy for acute myocardial infarction: Studies of animal experiments give valuable hints to clinical trials.
Int J Cardiol.  2009;  135   (1):   115-116


Wakatsuki Y‚ Funabashi N‚ Mikami Y‚ Shiina Y‚ Kawakubo M‚ Takahashi M‚ Yajima R‚ Uehara M‚ Takaoka H‚ Komuro I.   Left atrial compensatory function in subjects with early stage primary hypertension assessed by using left atrial volumetric emptying fraction acquired by transthoracic echocardiography.
Int J Cardiol.  2009;  136   (3):   363-367


Shiina Y‚ Funabashi N‚ Teramoto K‚ Uehara M‚ Takaoka H‚ Mikami Y‚ Takahashi A‚ Saito M‚ Daimon M‚ Lee K‚ Kawakubo M‚ Sekine Y‚ Takahashi M‚ Yajima R‚ Tani A‚ Komuro I.   Suitable solutions for reconstituting the ultrasound contrast agent "Levovist" used in contrast echocardiogram: In vitro and in vivo evaluation of the influence of osmotic pressure.
Int J Cardiol.  2009;  136   (3):   335-340


Sugimoto K‚ Kobayashi Y‚ Miyahara H‚ Kuroda N‚ Funabashi N‚ Komuro I.   Early Stent Thrombosis Because of Stent Dislodgement in a Coronary Artery Aneurysm.
Circ J.  2009;  73   (9):   1759-1761


Nakayama T‚ Kobayashi Y‚ Takano H‚ Kuroda N‚ Hiroshima K‚ Komuro I.   Silent Very Late Thrombotic Occlusion of Sirolimus-Eluting Stent Confirmed by Directional Coronary Atherectomy.
Circ J.  2009;  73   (9):   1762-1764


Kitahara H‚ Kobayashi Y‚ Takebayashi H‚ Nakamura Y‚ Kuroda N‚ Miyazaki A‚ Haruta S‚ Komuro I.   Angiographic patterns of restenosis after sirolimus-eluting stent implantation.
Circ J.  2009;  73   (3):   508-511


Akazawa H‚ Komuro I.   Change can happen" by PKA: proteasomes in in vivo hearts.
J Mol Cell Cardiol.  2009;  46   (4):   445-447


Orimo M‚ Minamino T‚ Miyauchi H‚ Tateno K‚ Okada S‚ Moriya J‚ Komuro I.   Protective Role of SIRT1 in Diabetic Vascular Dysfunction.
Arterioscler Thromb Vasc Biol.  2009;  29   (6):   889-894


Shiina Y‚ Funabashi N‚ Lee K‚ Daimon M‚ Sekine T‚ Kawakubo M‚ Sekine Y‚ Takahashi M‚ Yajima R‚ Wakatsuki Y‚ Tanabe N‚ Kuriyama T‚ Komuro I.   Doppler imaging predicts cardiac events in chronic pulmonary thromboembolism.
Int J Cardiol.  2009;  133   (2):   167-172


Hama Y‚ Funabashi N‚ Ueda M‚ Kanaeda T‚ Uehara M‚ Nakamura K‚ Murayama T‚ Mikami Y‚ Takaoka H‚ Kawakubo M‚ Lee K‚ Takano H‚ Komuro I.   Images in cardiovascular medicine. Right-sided heart wall thickening and delayed enhancement caused by chronic active myocarditis complicated by sustained monomorphic ventricular tachycardia.
Circulation  2009;  119   (6):   e200-203


Moriya J‚ Minamino T‚ Tateno K‚ Shimizu N‚ Sato Y‚ Kuwabara Y‚ Saito Y‚ Komuro I.   Long-term outcome of therapeutic neovascularization using peripheral blood mononuclear cells for limb ischemia.
Circ Cardiovasc Intervent.  2009;  2   (3):   245-254


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International Conferences

Komuro I Wnt signaling regulates cardiomyocyte differentiation and cardiac remodeling 
Advances in heart development:from molecules to cures 2009-9-28 Nice/France


Yoshida M‚ Shiojima I‚ Ikeda H‚ Komuro I. Pitavastatin attenuates doxorubicin-induced cardiotoxicity through the inhibition of oxidative stress-DNA damage-ATM-p53 pathway 
Basic Cardiocascular Science 2009 2009-7-20 Las Vegas/U.S.A.


Toko‚ H. ER Stress-Response Transcription Factor ATF6 Plays a Critical Role in Maintaining Cardiac Function under Physiological and Pathological Conditions 
6th Annual Symposium of the American Heart Association”Ēs Council on Basic Cardiovascular Sciences 2009-7-20 Las Vegas/USA


Komuro I Zhongshan Lecture 
The Role of Statin in the Treatment of Heart Failure 2009-12-7 Shanghai/China


Komuro I SIRIC International Forum 2009: Theme: Imaging for Shedding light to Atherosclerosis 
Senescenec as a cause of atherosclerosis and therapeutic angiogenesis using peripheral blood mononuclear cells 2009-12-11 Seoul/Korea


Tateno K‚ Minamino T‚ Komuro I. Notch Signaling in Intrinsic Stem Cell is a Prerequisite for Therapeutic Angiogenesis 
Scientific Session 2010 American Heart Association 2009-11-14 Orlando/USA


Komuro I The Third International Conference on Cell Therapy(IRICT) 
Long-Term Outcome of Therapeutic Neovascularization Using Peripheral Blood Mononuclear Cells for Limb Ischemia 2009-11-12 Seoul/Korea


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