千葉大学大学院医学研究院

消化器内科学

千葉大学病院

消化器内科

Nagai Y, Mimura N, Rizq O, Isshiki Y, Oshima M, Rzik M, Saraya A, Koide S, Nakajima-Takagi Y, Moyota M, Chiba T, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Lennox W, Sheedy J, Weetall M, Yokote K, Iwama A, Sakaida E. The combination of the tubulin binding small molecule PTC596 and bortezomib suppresses the growth of myeloma cells. Sci Rep. 2021 Jan 22;11(1):2074.

Fujiwara K, Yasui S, Kondo T, Yokosuka O, Kato N. Role of Autoimmunity in Patients Transplanted for Acute Liver Failure of Unknown Origin: A Clinical and Graft Biopsy Analysis. Liver Transpl. 2021 Feb;27(2):309-310.

Kudo M, Tsuchiya K, Kato N, Hagihara A, Numata K, Aikata H, Inaba Y, Kondo S, Motomura K, Furuse J, Ikeda M, Morimoto M, Achira M, Kuroda S, Kimura A. Cabozantinib in Japanese patients with advanced hepatocellular carcinoma: a phase 2 multicenter study. J Gastroenterol. 2021 Feb;56(2):181-190.

Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribasyashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A. Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score. Gut. 2021 Mar;70(3):476-484.

Yamauchi Y, Arai M, Akizue N, Ohta Y, Okimoto K, Matsumura T, Meng F, Imai C, Tawada A, Kato J, Kato N, Takiguchi Y. Colonoscopic Evaluation of Diarrhea/Colitis Occurring as an Immune-Related Adverse Event. Jpn J Clin Oncol. 2021 Mar 3;51(3):363-370.

Ryoo BY, Merle P, Kulkarni AS, Cheng AL, Bouattour M, Lim HY, Breder V, Edeline J, Chao Y, Ogasawara S, Yau T, Garrido M, Chan SL, Daniele B, Norquist JM, Chen E, Siegel AB, Zhu AX, Finn RS, Kudo M. Health-related quality-of-life impact of pembrolizumab versus best supportive care in previously systemically treated patients with advanced hepatocellular carcinoma: KEYNOTE-240. Cancer. 2021 Mar 15;127(6):865-874.

Hanai N, Shimizu Y, Kariya S, Yasumatsu R, Yokota T, Fujii T, Tsukahara K, Yoshida M, Hanyu K, Ueda T, Hirakawa H, Takahashi S, Ono T, Sano D, Yamauchi M, Watanabe A, Omori K, Yamazaki T, Monden N, Kudo N, Arai M, Sakurai D, Asakage T, Doi I, Yamada T, Homma A. Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real-world clinical practice: a multicenter retrospective clinical study. Int J Clin Oncol. 2021 Mar;26(3):494-506.

Hisanaga T, Hidaka I, Sakaida I, Nakayama N, Ido A, Kato N, Takikawa Y, Inoue K, Shimizu M, Genda T, Terai S, Tsubouchi H, Takikawa H, Mochida S, and Intractable Hepato‐Biliary Disease Study Group of Japan. Analysis of the safety of pretransplant corticosteroid therapy in patients with acute liver failure and late-onset hepatic failure in Japan. JGH Open. 2021 Mar 5;5(4):428-433.

Kanzaki H, Chiba T, Ao J, Koroki K, Kanayama K, Maruta S, Maeda T, Kusakabe Y, Kobayashi K, Kanogawa N, Kiyono S, Nakamura M, Kondo T, Saito T, Nakagawa R, Ogasawara S, Suzuki E, Ooka Y, Muroyama R, Nakamoto S, Yasui S, Tawada A, Arai M, Kanda T, Maruyama H, Mimura N, Kato J, Zen Y, Ohtsuka M, Iwama A, Kato N. The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma. Sci Rep. 2021 Mar 5;11(1):5303.

Ishikawa T, Matsumura T, Okimoto K, Nagashima A, Shiratori W, Kaneko T, Oura H, Tokunaga M, Akizue N, Ohta Y, Saito K, Arai M, Kato J, Kato N. Efficacy of Texture and Color Enhancement Imaging in visualizing gastric mucosal atrophy and gastric neoplasms. Sci Rep. 2021 Mar 25;11(1):6910.

Iino Y, Maruyama H, Mikata R, Yasui S, Koroki K, Nagashima H, Awatsu M, Shingyoji A, Kusakabe Y, Kobayashi K, Kiyono S, Nakamura M, Ohyama H, Sugiyama H, Sakai Y, Chiba T, Kato J, Tsuyuguchi T, Kato N. Percutaneous Two-Dimensional Shear Wave Elastography for Diagnosis of Pancreatic Tumor. Diagnostics. 2021 Mar 11;11(3):498.

Ao J, Chiba T, Shibata S, Qiang N, Ma Y, Kan M, Iwanaga T, Sakuma T, Kanzaki H, Kanayama K, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Kondo T, Ogasawara S, Suzuki E, Muroyama R, Kato J, Mimura N, Kanda T, Maruyama H, Kato N. Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2021 Apr 16;549:171-178.

Koroki K, Kanogawa N, Maruta S, Ogasawara S, Iino Y, Obu M, Okubo T, Itokawa N, Maeda T, Inoue M, Haga Y, Seki A, Okabe S, Koma Y, Azemoto R, Atsukawa M, Itobayashi E, Ito K, Sugiura N, Mizumoto H, Unozawa H, Iwanaga T, Sakuma T, Fujita N, Kanzaki H, Kobayashi K, Kiyono S, Nakamura M, Saito T, Kondo T, Suzuki E, Ooka Y, Nakamoto S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato J, Kato N. Posttreatment after Lenvatinib in Patients with Advanced Hepatocellular Carcinoma. Liver Cancer. 2021 Apr 20;10(5):473-484.

Sakai Y, Ohtsuka M, Sugiyama H, Mikata R, Yasui S, Ohno I, Iino Y, Kato J, Tsuyuguchi T, Kato N. Current status of diagnosis and therapy for intraductal papillary neoplasm of the bile duct. World J Gastroenterol. 2021 Apr 21;27(15):1569-1577.

Otoyama Y, Arai J, Goto K, Nozawa H, Nakagawa R, Muroyama R, Sugiura I, Nakajima Y, Kajiwara A, Tojo M, Ichikawa Y, Uozumi S, Shimozuma Y, Uchikoshi M, Sakaki M, Kato N, Yoshida H. Retinoids Decrease Soluble MICA Concentration by Inhibiting the Enzymatic Activity of ADAM9 and ADAM10. Anticancer Res. 2021 May;41(5):2307-2320.

Saeki I, Yamasaki T, Yamauchi Y, Takami T, Kawaoka T, Uchikawa S, Hiramatsu A, Aikata H, Kawano R, Kobayashi K, Kondo T, Ogasawara S, Chiba T, Chayama K, Kato N, Sakaida I. Skeletal Muscle Volume Is an Independent Predictor of Survival after Sorafenib Treatment Failure for Hepatocellular Carcinoma. Cancers (Basel). 2021 May 7;13(9):2247.

Ogasawara S, Choo SP, Li JT, Yoo C, Wang B, Lee D, Chow PKH. Evolving Treatment of Advanced Hepatocellular Carcinoma in the Asia-Pacific Region: A Review and Multidisciplinary Expert Opinion. Cancers (Basel). 2021 May 27;13(11):2626.

Yoshida R, Koroki K, Makishima H, Ogasawara S, Ishino T, Ogawa K, Nakagawa M, Fujiwara K, Unozawa H, Iwanaga T, Fujita N, Sakuma T, Kanzaki H, Kobayashi K, Kanogawa N, Kiyono S, Nakamura M, Kondo T, Saito T, Nakagawa R, Suzuki E, Ooka Y, Nakamoto S, Tawada A, Chiba T, Arai M, Kaneko T, Wakatsuki M, Kato J, Tsuji H, Kato N. Controlling Major Portal Vein Invasion Progression during Lenvatinib Treatment by Carbon-Ion Radiotherapy in Patients with Advanced Hepatocellular Carcinoma. Case Rep Oncol. 2021;14:1103–1110

Cadoni S, Ishaq S, Hassan C, Přemysl Falt, Fuccio L, Siau K, Leung JW, Anderson J, Binmoeller KF, Radaelli F, Rutter MD, Sugimoto S, Muhammad H, Bhandari P, Draganov PV, Piet de Groen, Wang AY, Yen AW, Hamerski C, Thorlacius H, Neumann H, Ramirez F, Mulder CJ, Albéniz E, Amato A, Arai M, Bak A, Barret M, Bayupurnama P, Cheung R, Ching HL, Cohen H, Dolwani S, Friedland S, Harada H, Hsieh YH, Hayee B, Kuwai T, Lorenzo-Zúñiga V, Liggi M, Mizukami T, Mura D, Nylander D, Olafsson S, Paggi S, Pan Y, Parra-Blanco A, Ransford R, Rodriguez-Sanchez J, Senturk H, Suzuki N, Tseng CW, Uchima H, Uedo N, Leung FW. Water-assisted colonoscopy: an international modified Delphi review on definitions and practice recommendations. Gastrointest Endosc. 2021 Jun;93(6):1411-1420.e18.

Kudo M, Kawamura Y, Hasegawa K, Tateishi R, Kariyama K, Shiina S, Toyoda H, Imai Y, Hiraoka A, Ikeda M, Izumi N, Moriguchi M, Ogasawara S, Minami Y, Ueshima K, Murakami T, Miyayama S, Nakashima O, Yano H, Sakamoto M, Hatano E, Shimada M, Kokudo N, Mochida S, Takehara T. Management of Hepatocellular Carcinoma in Japan: JSH Consensus Statements and Recommendations 2021 Update. Liver Cancer. 2021 Jun;10(3):181-223.

Kubota-Aizawa S, Matsubara Y, Kanemoto H, Mimuro H, Uchida K, Chambers J, Tsuboi M, Ohno K, Fukushima K, Kato N, Yotsuyanagi H, Tsujimoto H. Transmission of Helicobacter pylori between a human and two dogs: A case report. Helicobacter. 2021 Jun;26(3):e12798.

Kudo M, Lim HY, Cheng AL, Chao Y, Yau TCC, Ogasawara S, Kurosaki M, Morimoto N, Ohkawa K, Yamashita T, Lee KH, Chen E, Siegel AB, Ryoo BY. Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma: A Subgroup Analysis of Asian Patients in the Phase 3 KEYNOTE-240 Trial. Liver Cancer. 2021 Jun;10(3):275-284.

Akizue N, Okimoto K, Arai M, Hirotsu Y, Amemiya K, Imai Y, Oike T, Yokoyama Y, Ishikawa K, Ohta Y, Taida T, Saito K, Maruoka D, Matsumura T, Nakagawa T, Nishimura M, Matsushita K, Mochizuki H, Yokosuka O, Omata M, Kato N. Comprehensive mutational analysis of background mucosa in patients with Lugol-voiding lesions. Cancer Med. 2021 Jun;10(11):3545-3555.

Shinzaki S, Matsuoka K, Tanaka H, Takeshima F, Kato S, Torisu T, Ohta Y, Watanabe K, Nakamura S, Yoshimura N, Kobayashi T, Shiotani A, Hirai F, Hiraoka S, Watanabe M, Matsuura M, Nishimoto S, Mizuno S, Iijima H, Takehara T, Naka T, Kanai T, Matsumoto T. Leucine-rich alpha-2 glycoprotein is a potential biomarker to monitor disease activity in inflammatory bowel disease receiving adalimumab: PLANET study. J Gastroenterol. 2021 Jun;56(6):560-569.

Hiwasa T, Wang H, Goto KI, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kunimatsu M, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Muto M, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Hattori A, Yamamoto M, Maezawa Y, Kobayashi K, Ishibashi R, Takemoto M, Yokote K, Takizawa H, Kishimoto T, Matsushita K, Kobayashi S, Nomura F, Arasawa T, Kagaya A, Maruyama T, Matsubara H, Tomiita M, Hamanaka S, Imai Y, Nakagawa T, Kato N, Terada J, Matsumura T, Katsumata Y, Naito A, Tanabe N, Sakao S, Tatsumi K, Ito M, Shiratori F, Sumazaki M, Yajima S, Shimada H, Shirouzu M, Yokoyama S, Kudo T, Doi H, Iwase K, Ashino H, Li SY, Kubota M, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y. Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC Med. 2021 Jun 9;19(1):131.

Ueno M, Morizane C, Okusaka T, Mizusawa J, Kataoka T, Ikeda M, Ozaka M, Okano N, Sugimori K, Todaka A, Shimizu S, Mizuno N, Yamamoto T, Sano K, Tobimatsu K, Katanuma A, Miyamoto A, Yamaguchi H, Nishina T, Shirakawa H, Kojima Y, Oono T, Kawamoto Y, Furukawa M, Iwai T, Sudo K, Miyakawa H, Yamashita T, Yasuda I, Takahashi H, Kato N, Shioji K, Shimizu K, Nakagohri T, Kamata K, Ishii H, Furuse J; members of the Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG). Comparison of gemcitabine-based chemotherapies for advanced biliary tract cancers by renal function: an exploratory analysis of JCOG1113. Scand J Gastroenterol. 2021 Jun 18;11(1):12885.

Minami T, Tateishi R, Fujiwara N, Nakagomi R, Nakatsuka T, Sato M, Uchino K, Enooku K, Nakagawa H, Fujinaga H, Izumiya M, Hanajiri K, Asaoka Y, Kondo Y, Tanaka Y, Otsuka M, Ohki T, Arai M, Tanaka A, Yasuda K, Miura H, Ogata I, Kamoshida T, Inoue K, Koike Y, Akamatsu M, Mitsui H, Fujie H, Ogura K, Yoshida H, Wada T, Kurai K, Maekawa H, Obi S, Teratani T, Masaki N, Kamiichi H, Ishikawa T, Kato N, Moriya K, Yotsuyanagi H, Koike K for SMART-C investigators. Impact of Obesity and Heavy Alcohol Consumption on Hepatocellular Carcinoma Development after HCV Eradication with Antivirals. Liver Cancer. 2021 Jul;10(4):309-319.

Takeuchi T, Miyauchi E, Kanaya T, Kato T, Nakanishi Y, Watanabe T, Kitami T, Taida T, Sasaki T, Negishi H, Shimamoto S, Matsuyama A, Kimura I, Williams IR, Ohara O, Ohno H. Acetate differentially regulates IgA reactivity to commensal bacteria. Nature. 2021 Jul;595(7868):560-564.

Ishikawa K, Okimoto K, Matsumura T, Hirotsu Y, Amemiya K, Kishimoto T, Imai Y, Oike T, Yokoyama Y, Akizue N, Ohta Y, Taida T, Saito K, Maruoka D, Nakagawa T, Nishimura M, Matsushita K, Mochizuki H, Arai M, Kato J, Yokosuka O, Omata M, Kato N. Comprehensive Analysis of Barrett's Esophagus: Focused on Carcinogenic Potential for Barrett's Cancer in Japanese Patients. Dig Dis Sci. 2021 Aug;66(8):2674-2681.

Suganuma E, Ishikawa T, Kitamura Y, Hayashida T, Matsumura T, Fujie M, Nozaki-Taguchi N, Sato Y, Isono S. Recovery of lower oesophageal barrier function: a pilot study comparing a mixture of atropine and neostigmine and sugammadex: A randomised controlled pilot study. Eur J Anaesth. 2021 Aug 1;38(8):856-864.

Mikata R, Yasui S, Kishimoto T, Kouchi Y, Shingyoji A, Senoo J, Takahashi K, Nagashima H, Kusakabe Y, Ohyama H, Ohno I, Sugiyama H, Chiba T, Kato J, Kato N. Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors. Sci Rep. 2021 Aug 26;11(1):17257.

Tokunaga M, Okimoto K, Akizue N, Ishikawa K, Hirotsu Y, Amemiya K, Ota M, Matsusaka K, Nishimura M, Matsushita K, Ishikawa T, Nagashima A, Shiratori W, Kaneko T, Oura H, Kanayama K, Ohta Y, Taida T, Saito K, Matsumura T, Chiba T, Mochizuki H, Arai M, Kato J, Ikeda J, Omata M, Kato N. Genetic Profiles of Barrett’s Esophagus and Esophageal Adenocarcinoma in Japanese patients. Sci Rep. 2021 Sep 3;11(1):17671.

Kamezaki H, Iwanaga T, Maeda T, Senoo JI, Sakamoto D, Yasui S, Sugiyama H, Tsuyuguchi T, Kato N. Long-term effects of endoscopic papillary large balloon dilation in patients with challenging bile duct calculi: A retrospective observational study. Medicine (Baltimore). 2021 Sep 10;100(36):e27227.

Takahashi S, Matsumura T, Kaneko T, Tokunaga M, Oura H, Ishikawa T, Nagashima A, Shiratori W, Akizue N, Ohta Y, Kikuchi A, Fujie M, Saito K, Okimoto K, Maruoka D, Nakagawa T, Arai M, Kato J, Kato N. Clinical Characteristics of Esophageal Motility Disorders in Patients With Heartburn. J Neurogastroenterol Motil. 2021 Oct 30;27(4):545-554.

Ohyama H, Hirotsu Y, Amemiya K, Oyama T, Iimuro Y, Kojima Y, Mikata R, Mochizuki H, Kato N, Omata M. Detection of actionable mutations in archived cytological bile specimens. J Hepatobiliary Pancreat Sci. 2021 Oct;28(10):837-847.

Shiroma S, Yoshio T, Hatta W, Tsuji Y, Yabuuchi Y, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Fujishiro M, Masamune A, Ohira H. Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan. J Gastroenterol Hepatol. 2021 Oct;36(10):2769-2777.

Sakai Y, Sugiyama H, Kawaguchi Y, Kawashima Y, Hirata N, Nakaji S, Natsui M, Shioji K, Nakahara K, Tsuyuguchi T, Kato N. Uncovered versus covered metallic stents for the management of unresectable malignant distal biliary obstruction: a randomized multicenter trial. Scand J Gastroenterol. 2021 Oct;56(10):1229-1235.

Kakizaki M, Yamamoto Y, Nakayama S, Kameda K, Nagashima E, Ito M, Suyama T, Matsuzaki Y, Chiba T, Sumiyoshi H, Inagaki Y, Kotani A. Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice. Cell Death Dis. 2021 Oct 27;12(11):1010.

Mukai S, Kanzaki H, Ogasawara S, Ishino T, Ogawa K, Nakagawa M, Fujiwara K, Unozawa H, Iwanaga T, Sakuma T, Fujita N, Koroki K, Kobayashi K, Kanogawa N, Kiyono S, Nakamura M, Kondo T, Saito T, Nakagawa R, Suzuki E, Ooka Y, Muroyama R, Nakamoto S, Tawada A, Chiba T, Arai M, Kato J, Shiina M, Ota M, Ikeda J, Takiguchi Y, Ohtsuka M, Kato N. Exploring microsatellite instability in patients with advanced hepatocellular carcinoma and its tumor microenvironment. JGH Open. 2021 Oct 1;5(11):1266-1274.

Higuchi R, Goto T, Hirotsu Y, Otake S, Oyama T, Amemiya K, Ohyama H, Mochizuki H, Omata M. Sphingomonas and Phenylobacterium as Major Microbiota in Thymic Epithelial Tumors. J Pers Med. 2021 Oct 26;11(11):1092.

Hashimoto M, Hatta W, Tsuji Y, Yoshio T, Kakushima N, Hoteya S, Doyama H, Nagami Y, Hikichi T, Kobayashi M, Morita Y, Sumiyoshi T, Iguchi M, Tomida H, Inoue T, Koike T, Mikami T, Hasatani K, Nishikawa J, Matsumura T, Nebiki H, Nakamatsu D, Ohnita K, Suzuki H, Ueyama H, Hayashi Y, Sugimoto M, Yamaguchi S, Michida T, Yada T, Asahina Y, Narasaka T, Kuribayashi S, Kiyotoki S, Mabe K, Nakamura T, Nakaya N, Fujishiro M, Masamune A Rebleeding in patients with delayed bleeding after endoscopic submucosal dissection for early gastric cancer. Dig Endosc. 2021 Nov;33(7):1120-1130.

Minamide T, Sashiyama H, Muramatsu Y, Yada T, Matsumura T, Takeda S, Suzuki T, Kakimoto T, Yano T, Yoshii K, Arai M, Uemura N, Yamaguchi T, Ikematsu H. Second-generation narrow-band imaging to detect colorectal adenomas: A multicenter study including community hospitals. J Gastroenterol Hepatol. 2021 Nov;36(11):3084-3091.

Kusakabe Y, Chiba T, Oshima M, Koide S, Rizq O, Aoyama K, Ao J, Kaneko T, Kanzaki H, Kanayama K, Maeda T, Saito T, Nakagawa R, Kobayashi K, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Nakamoto S, Yasui S, Mikata R, Muroyama R, Kanda T, Maruyama H, Kato J, Mimura N, Ma A, Jin J, Zen Y, Otsuka M, Kaneda A, Iwama A, Kato N. EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma. Sci Rep. 2021 Nov 1;11(1):21396.

Amano H, Kanda T, Mochizuki H, Kojima Y, Suzuki Y, Hosoda K, Ashizawa H, Miura Y, Tsunoda S, Hirotsu Y, Ohyama H, Kato N, Moriyama M, Obi S, Omata M. The Use of Electronic Medical Records-Based Big-Data Informatics to Describe ALT Elevations Higher than 1000 IU/L in Patients with or without Hepatitis B Virus Infection. Viruses. 2021 Nov 4;13(11):2216.

Kobayashi K, Ogasawara S, Takahashi A, Seko Y, Unozawa H, Sato R, Watanabe S, Moriguchi M, Morimoto N, Tsuchiya S, Iwai K, Inoue M, Ogawa K, Ishino T, Iwanaga T, Sakuma T, Fujita N, Kanzaki H, Koroki K, Nakamura M, Kanogawa N, Kiyono S, Kondo T, Saito T, Nakagawa R, Suzuki E, Ooka Y, Nakamoto S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Nagashima K, Kato J, Isoda N, Aramaki T, Itoh Y, Kato N. Evolution of survival impact of molecular target agents in patients with advanced hepatocellular carcinoma. Liver Cancer. 2021 Dec 6;11(1):48-60.

Nakayama N, Uemura H, Uchida Y, Imai Y, Tomiya T, Terai S, Yoshiji H, Genda T, Ido A, Inoue K, Kato N, Sakaida I, Shimizu M, Takikawao Y, Abe M, Abe R, Chayama K, Hasegawa K, Inui A, Kasahara M, Ohira H, Tanaka A, Takikawa H, Mochida S. Nationwide Survey for Patients with Acute-on-Chronic Liver Failure Occurring between 2017 and 2019 and Diagnosed According to Proposed Japanese Criteria. J Gastroenterol. 2021 Dec;56(12):1092-1106.

Kondo T, Macdonald S, Engelmann C, Habtesion A, Macnaughtan J, Mehta G, Mookerjee RP, Davies N, Pavesi M, Moreau R, Angeli P, Arroyo V, Andreola F, Jalan R. The role of RIPK1 mediated cell death in acute on chronic liver failure. Cell Death Dis. 2021 Dec 17;13(1):5.

Ao J, Chiba T, Kanzaki H, Kanayama K, Shibata S, Kurosugi A, Iwanaga T, Kan M, Sakuma T, Qiang N, Ma Y, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Kondo T, Ogasawara S, Suzuki E, Nakamoto S, Muroyama R, Tawada A, Kato J, Kanda T, Maruyama H, Kato N. Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma. J Cancer. 2021; 12(9):2694-2701.

Kasai H, Ito S, Tajima H, Takahashi Y, Sakurai Y, Kawata N, Sugiyama H, Asahina M, Sakai I, Tatsumi K. The positive effect of student-oriented clinical clerkship rounds employing role-play and peer review on the clinical performance and professionalism of clerkship students. Med Teach. 2020 Jan;42(1):73-78.

Maruyama H, Kobayashi K, Kiyono S, Chiba T, Kato N, Ohtsuka M, Ito K, Yamaguchi T, Shiina S. Free fatty acid-based low-impedance liver image: a characteristic appearance in nonalcoholic steatohepatitis (NASH). Eur Radiol Exp. 2020 Jan 23;4(1):3.

Sato N, Takano S, Yoshitomi H, Furukawa K, Takayashiki T, Kuboki S, Suzuki D, Sakai N, Kagawa S, Mishima T, Nakadai E, Mikata R, Kato N, Ohtsuka M. Needle tract seeding recurrence of pancreatic cancer in the gastric wall with paragastric lymph node metastasis after endoscopic ultrasound-guided fine needle aspiration followed by pancreatectomy: a case report and literature review. BMC Gastroenterol. 2020 Jan 15;20(1):13.

Engelmann C, Sheikh M, Sharma S, Kondo T, Loeffler-Wirth H, Zheng YB, Novelli S, Hall A, Kerbert AJC, Macnaughtan J, Mookerjee R, Habtesion A, Davies N, Ali T, Gupta S, Andreola F, Jalan R. Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure. J Hepatol. 2020 Jan 24;S0168-8278(20)30028-3.

Ogasawara S, Ooka Y, Itokawa N, Inoue M, Okabe S, Seki A, Haga Y, Obu M, Atsukawa M, Itobayashi E, Mizumoto H, Sugiura N, Azemoto R, Kanayama K, Kanzaki H, Maruta S, Maeda T, Kusakabe Y, Yokoyama M, Kobayashi K, Kiyono S, Nakamura M, Saito T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N. Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan. Invest New Drugs. 2020 Feb;38(1):172-180.

Ogasawara S, Ooka Y, Kato N. Weight-based dosing of lenvatinib for advanced hepatocellular carcinoma. Hepatobiliary Surg Nutr. 2020 Feb;9(1):253-254.

Sarin SK, Kumar M, Eslam M, George J, Al Mahtab M, Akbar SMF, Jia J, Tian Q, Aggarwal R, Muljono DH, Omata M, Ooka Y, Han KH, Lee HW, Jafri W, Butt AS, Chong CH, Lim SG, Pwu RF, Chen DS. Liver diseases in the Asia-Pacific region: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastroenterol Hepatol. 2020 Feb;5(2):167-228.

Oura H, Matsumura T, Kawasaki Y, Okimoto K, Ishikawa K, Kaneko T, Tokunaga M, Oike T, Imai Y, Yokoyama Y, Akizue N, Maruoka D, Ohta Y, Saito K, Nakagawa T, Arai M, , Kato J, Kato N. Long-term use of proton pump inhibitors does not affect ectopic and metachronous recurrence of gastric cancer after endoscopic treatment. Scand J Gastroenterol. 2020 Feb;55(2):209-215.

Kanayama K, Chiba T, Kobayashi K, Koroki K, Maruta S, Kanzaki H, Kusakabe Y, Saito T, Kiyono A, Nakamura M, Ogasawara S, Suzuki E, Ooka Y, Nakamoto S, Yasui S, Kanda T, Maruyama H, Kato J, Kato N. Long-term administration of Tolvaptan to patients with decompensated cirrhosis. Int J Med Sci. 2020 Mar 15;17(7):874-880.

Kamezaki H, Tsuyuguchi T, Shimura K, Sakamoto D, Senoo J, Mizumoto H, Kubota M, Yoshida Y, Azemoto R, Sugiyama H, Kato N. Safety and Efficacy of Early Tube Removal Following Percutaneous Transhepatic Gallbladder Drainage: An Observational Study. Surg Laparosc Endosc Percutan Tech. 2020 Apr;30(2):164-168.

Ogasawara S, Ooka Y, Koroki K, Maruta S, Kanzaki H, Kanayama K, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kato J, Kato N. Switching to systemic therapy after locoregional treatment failure: Definition and best timing. Clin Mol Hepatol. 2020 Apr;26(2):155-162.

Yamato M, Mikata R, Yasui S, Iino Y, Shingyoji A, Kusakabe Y, Ohyama H, Sugiyama H, Sakai Y, Tsuyuguchi T, Yoshitomi H, Ohtsuka M, Kishimoto T, Kato N. Endoscopic Ultrasound Criteria for Arterial Invasion in Pancreatic Cancer of the Body and Tail. Pancreas. 2020 Apr;49(4):561-567.

Nakaji S, Okawa Y, Nakamura K, Itonaga M, Inase M, Sugiyama H, Suzuki R, Yamauchi K, Matsui H, Hirata N, Saito J, Ishii N, Tsuyuguchi T, Kato H, Kitano M, Kato N, Ohira H, Okada H, Torimura T, Maguchi H. Predictive model of bleeding following endoscopic sphincterotomy for the treatment of choledocholithiasis in hemodialysis patients: A retrospective multicenter study. JGH Open. 2020 May 17;4(5):915-922.

Fujisawa T, Shimamura T, Goto K, Nakagawa R, Muroyama R, Ino Y, Horiuchi H, Endo I, Maeda S, Harihara Y, Nakajima A, Matsuhashi N, Kato N, Isayama H, Puri A, Suzuki A, Bellayr I, Leland P, Joshi BH, Puri RK. A Novel Role of Interleukin 13 Receptor alpha2 in Perineural Invasion and Its Association With Poor Prognosis of Patients With Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2020 May 20;12(5):1294.

Matsumura T, Arai M, Suzuki T, Hoppo T, Seki Y, Kasamatsu S, Ishigami H, Ishikawa K, Okimoto K, Akizue N, Maruoka D, Nakagawa T, Odaka T, Okamoto Y, Kato N. Clinical utility of salivary pepsin measurement in patients with proton pump inhibitor-refractory gastroesophageal reflux disease symptoms: a prospective comparative study. Esophagus. 2020 Jul;17(3):339-347.

Yamamoto Y, Kakizaki M, Shimizu T, Carreras J, Chiba T, Chamoto K, Kagawa T, Aoki T, Nakamura N, Ando K, Kotani A. PD-L1 is induced on the hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 up-regulation by the anti-HBV drug Entecavir. Int Immunol. 2020 Jul 28;32(8):519-531.

Kudo M, Morimoto M, Moriguchi M, Izumi N, Takayama T, Yoshiji H, Hino K, Oikawa T, Chiba T, Motomura K, Kato J, Yasuchika K, Ido A, Sato T, Nakashima D, Ueshima K, Ikeda M, Okusaka T, Tamura K, Furuse J. A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma. Cancer Sci. 2020 Jul 27;111(10):3759-3769.

Tokunaga M, Matsumura T, Nankinzan R, Suzuki T, Oura H, Kaneko T, Fujie M, Hirai S, Saiki R, Akizue N, Okimoto K, Arai M, Kato J, Kato N. Computer-aided diagnosis system using only white-light endoscopy for the prediction of invasion depth in colorectal cancer. Gastrointest Endosc. 2020 Jul 29;S0016-5107(20)34648-4.

Maruta S, Ogasawara S, Ooka Y, Obu M, Inoue M, Itokawa N, Haga Y, Seki A, Okabe S, Azemoto R, Itobayashi E, Atsukawa M, Sugiura N, Mizumoto H, Koroki K, Kanayama K, Kanzaki H, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N. Potential of Lenvatinib for an Expanded Indication from the REFLECT Trial in Patients with Advanced Hepatocellular Carcinoma. Liver Cancer. 2020 Aug;9(4):382-396.

Koroki K, Ogasawara S, Ooka Y, Kanzaki H, Kanayama K, Maruta S, Maeda T, Yokoyama M, Wakamatsu T, Inoue M, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato J, Kuboki S, Ohtsuka M, Miyazaki M, Yokosuka O, Kato N. Analyses of intermediate-stage hepatocellular carcinoma patients receiving TACE prior to designing clinical trials. Liver Cancer. 2020 Sep;9(5):596-612.

Viet HD, Matsumura T, Kaneko T, Takahashi S, Tokunaga M, Oura H, Ishikawa K, Akizue N, Kikuchi A, Fujie M, Saito K, Okimoto K, Maruoka D, Nakagawa T, Arai M, Kato J, Kato N. Impact of Ineffective Esophageal Motility on Chemical Clearance in Patients with Gastroesophageal Reflux Symptoms. Dis Esophagus. 2020 Sep 4;33(9):doaa026.

Imai Y, Chiba T, Kondo T, Ao J, Kanayama K, Kanzaki H, Kusakabe Y, Nakagawa R, Nakamura M, Nakamoto H, Muroyama R, Tawada A, Matsumura T, Nakagwa T, Kato J, Kotani A, Matsubara H, Kato N. Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer. Oncol Lett. 2020 Sep;20(3):2161-2168.

Ueshima K, Ogasawara S, Ikeda M, Yasui Y, Terashima T, Yamashita T, Obi S, Sato S, Aikata H, Ohmura T, Hidekatsu K, Ohki T, Nagashima K, Ooka Y, Takita M, Kurosaki M, Chayama K, Kaneko S, Izumi N, Kato N, Kudo M, Omata M. Hepatic Arterial Infusion Chemotherapy versus Sorafenib in Patients with Advanced Hepatocellular Carcinoma. Liver Cancer. 2020 Sep;9(5):583-595

Fujiwara K, Nakayama N, Kato N, Yokosuka O, Tsubouchi H, Takikawa H, Mochida S, the Intractable Hepato-Biliary Diseases Study Group of Japan. Infectious complications and timing for liver transsplantation in autoimmune acute liver failure in Japan: A subanalysis based on nationwide surveys between 2010 and 2015. J Gastroenterol. 2020 Sep;55(9):888-898.

Tokunaga M, Matsumura T, Ishikawa K, Kaneko T, Oura H, Ishikawa T, Nagashima A, Shiratori W, Okimoto K, Akizue N, Maruoka D, Ohta Y, Saito K, Nakagawa T, Chiba T, Arai M, Kato J, Kato N. The Efficacy of Linked Color Imaging in the Endoscopic Diagnosis of Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterol Res Pract. 2020 Sep 29;2020:9604345.

Okimoto K, Maruoka D, Matsumura T, Tokunaga M, Kaneko T, Oura H, Akizue N, Ohta Y, Arai M, Kato J, Kato N. Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors. Sci Rep. 2020 Nov 26;10(1):20667.

Shingyoji A, Mikata R, Ogasawara S, Asano K, Miura Y, Shima Y, Sensui M, Nagashima H, Koroki K, Iino Y, Takahashi K, Kumagai J, Yamato M, Ohyama H, Nakagawa R, Suzuki E, Kusakabe Y, Yasui S, Sugiyama H, Ohno I, Tawada A, Arai M, Tsuyuguchi T, Kato J, Takano S, Yoshitomi H, Ohtsuka M, Kato N. Diverse transitions in diabetes status during the clinical course of patients with resectable pancreatic cancer. Jpn J Clin Oncol. 2020 Dec 16;50(12):1403-1411.

Kanogawa N, Ogasawara S, Ooka Y, Inoue M, Wakamatsu T, Yokoyama M, Maruta S, Unozawa H, Iwanaga T, Sakuma T, Fujita N, Koroki K, Kanzaki H, Maeda T, Kobayashi K, Kiyono S, Nakamura M, Kondo T, Saito1 T, Motoyama T, Suzuki E, Nakamoto S, Tawada1,3, Tetsuhiro A, Chiba T, Arai1 M, Kanda T, Maruyama H, Kato J, Takemura R, Nozaki-Taguchi N, Isono S, Yokosuka O, Kato N. Propofol versus midazolam for sedation during radiofrequency ablation in patients with hepatocelluar carcionoma. JGH Open. 2020 Dec 22;5(2):273-279.