【抄読会】毎週月曜日の正午からZoomを利用したWebミーティング形式で，私たちの診療，研究に関わる論文のプレゼンテーションを行っております．
2024年
【2024.12.16】
テーマ：Driving pressureの年齢別の予後への影響〔担当 柄澤智史〕
Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome.
Eleni Papoutsi, et al.
Am J Respir Crit Care Med. 2024 Dec 1;210(11):1329-1337. doi: 10.1164/rccm.202401-0049OC.
テーマ：敗血症性ショックに対する新たな昇圧薬の可能性〔担当 馬渡千晴〕
Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial.
Fabio Luis-Silva, et al.
Front Med (Lausanne). 2024 Oct 14:11:1431321. doi: 10.3389/fmed.2024.1431321. eCollection 2024.
【2024.12.9】
テーマ：中心静脈カテーテルの留置位置〔担当 石田茂誠〕
Central venous catheter-related infection: does insertion site still matter? A French multicentric cohort study.
Vincent Cosme, et al.
Intensive Care Med. 2024 Nov;50(11):1830-1840. doi: 10.1007/s00134-024-07615-0. Epub 2024 Sep 17.
テーマ：抗菌薬デエスカレーションと耐性菌〔担当 田﨑康太郎〕
Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study.
Besu F Teshome, et al.
Clin Infect Dis. 2024 Oct 15;79(4):826-833. doi: 10.1093/cid/ciae253.
【2024.12.2】
テーマ：血流感染症に対する抗菌薬治療期間7日 vs 14日〔担当 近藤乾伍〕
Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections.
BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network; Nick Daneman, et al.
N Engl J Med. 2024 Nov 20. doi: 10.1056/NEJMoa2404991. Online ahead of print.
Bloodstream infections in critically ill patients: an expert statement.
Jean-François Timsit, et al.
Intensive Care Med. 2020 Feb;46(2):266-284. doi: 10.1007/s00134-020-05950-6. Epub 2020 Feb 11.
テーマ：ECPELLAを導入した心原性ショック患者におけるNO吸入療法の効果につ
いて〔担当 飯島将信〕
Impact of inhaled nitric oxide therapy in patients with cardiogenic shock treated with veno-arterial extracorporeal membrane oxygenation combined with Impella: a retrospective cohort study.
Nobuhiro Yamada, et al.
J Intensive Care. 2024 Nov 18;12(1):49. doi: 10.1186/s40560-024-00761-z.
【2024.11.25】
テーマ：敗血症性ショックに対するステロイド補充療法〔担当 今田 寛〕
Effect of hydrocortisone-fludrocortisone combination on mortality in septic shock: a systematic review and meta-analysis.
Jheng-Yen Wu, et al.
Infection. 2024 Aug 27. doi: 10.1007/s15010-024-02381-z. Online ahead of print.
Effect of Continuous Infusion vs Bolus Dose of Hydrocortisone in Septic Shock: A Prospective Randomized Study.
Rashmi Salhotra, et al.
Indian J Crit Care Med. 2024 Sep;28(9):837-841. doi: 10.5005/jp-journals-10071-24793. Epub 2024 Aug 31.
テーマ：人工呼吸器管理下での持続栄養投与と間欠栄養投与の比較〔担当 福味徹也〕
A multicenter randomized controlled trial comparing three-times-a-day intermittent enteral postural feeding to continuous enteral feeding among mechanically ventilated patients in intensive care.
Rakshit Panwar, et al.
Clin Nutr. 2024 Sep;43(9):2149-2155. doi: 10.1016/j.clnu.2024.07.038. Epub 2024 Jul 31.
【2024.11.18】
テーマ：高齢NTEMIの治療戦略〔担当 池田優〕
Invasive Treatment Strategy for Older Patients with Myocardial Infarction.
Vijay Kunadian, et al.
N Engl J Med. 2024 Nov 7;391(18):1673-1684. doi: 10.1056/NEJMoa2407791. Epub 2024 Sep 1.
テーマ：敗血症患者における人工呼吸管理開始のタイミングと転帰の関連〔担当 中尾漱〕
Impact of the timing of invasive mechanical ventilation in patients with sepsis: a multicenter cohort study.
Gyungah Kim, et al.
Crit Care. 2024 Sep 9;28(1):297. doi: 10.1186/s13054-024-05064-1.
【2024.11.11】
テーマ：蘇生中の換気方法の比較〔担当 馬場彩夏〕
Automatic Mechanical Ventilation vs Manual Bag Ventilation During CPR: A Pilot Randomized Controlled Trial.
Jonghwan Shin, et al.
Chest. 2024 Aug;166(2):311-320. doi: 10.1016/j.chest.2024.02.020. Epub 2024 Feb 18.
テーマ：院外心停止での薬剤投与経路の無作為化試験〔担当 小松浩一郎〕
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest.
Keith Couper, et al.
N Engl J Med. 2024 Oct 31:10.1056/NEJMoa2407780. doi: 10.1056/NEJMoa2407780. Online ahead of print.
【2024.10.28】
テーマ：長期酸素療法〔担当 飛世知宏〕
Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia.
Magnus Ekström, et al.
N Engl J Med. 2024 Sep 19;391(11):977-988. doi: 10.1056/NEJMoa2402638. Epub 2024 Sep 10.
テーマ：院外心停止後脳損傷に対する水素吸入と体温管理療法の併用効果〔担当 鈴木俊将〕
Combination of Hydrogen Inhalation and Hypothermic Temperature Control After Out-of-Hospital Cardiac Arrest: A Post hoc Analysis of the Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care II Trial.
Tomoyoshi Tamura, et al.
Crit Care Med. 2024 Oct 1;52(10):1567-1576. doi: 10.1097/CCM.0000000000006395. Epub 2024 Aug 12.
Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.
Tomoyoshi Tamura, et al.
EClinicalMedicine. 2023 Mar 17:58:101907. doi: 10.1016/j.eclinm.2023.101907. eCollection 2023 Apr.
【2024.10.21】
テーマ：脳卒中患者の発熱予防〔担当 近藤乾伍〕
Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial.
David M Greer, et al.
JAMA. 2024 Sep 25:e2414745. doi: 10.1001/jama.2024.14745. Online ahead of print.
テーマ：SBTの方法と頻度〔担当 池邉茉莉〕
Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial.
Karen E A Burns, et al.
JAMA. 2024 Oct 9. doi: 10.1001/jama.2024.20631. Online ahead of print.
【2024.10.7】
テーマ：頭部外傷における輸血戦略〔担当 山本晃之〕
Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury.
Alexis F Turgeon, et al.
N Engl J Med. 2024 Aug 22;391(8):722-735. doi: 10.1056/NEJMoa2404360. Epub 2024 Jun 13.
テーマ：ブタにおける腸を用いた換気法の有効性〔担当 兼松里衣〕
Enteral liquid ventilation oxygenates a hypoxic pig model.
Tasuku Fujii, et al.
iScience. 2023 Feb 13;26(3):106142. doi: 10.1016/j.isci.2023.106142. eCollection 2023 Mar 17.
Mammalian enteral ventilation ameliorates respiratory failure.
Ryo Okabe, et al.
Med. 2021 Jun 11;2(6):773-783.e5. doi: 10.1016/j.medj.2021.04.004. Epub 2021 May 14.
【2024.9.30】
テーマ：留学報告, 敗血症における腸管恒常性やマイクロバイオーム〔担当 島居傑〕
Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis.
Silei Sun, et al.
Crit Care. 2023 Mar 28;27(1):127. doi: 10.1186/s13054-023-04412-x.
Efficacy of probiotics or synbiotics in critically ill patients: Asystematic review and meta-analysis.
Jiaqi Lou, et al.
Clin Nutr ESPEN. 2024 Feb:59:48-62. doi: 10.1016/j.clnesp.2023.11.003. Epub 2023 Nov 8.
Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
C Adam Lorentz, et al.
Mol Med. 2017 Aug:23:155-165. doi: 10.2119/molmed.2016.00256. Epub 2017 Jun 7.
Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.
Takehiko Oami, et al.
Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2217877121. doi: 10.1073/pnas.2217877121. Epub 2024 Feb 27.
Paracellular permeability and tight junction regulation in gut health and disease.
Arie Horowitz, et al.
Nat Rev Gastroenterol Hepatol. 2023 Jul;20(7):417-432. doi: 10.1038/s41575-023-00766-3. Epub 2023 Apr 25.
The gut microbiome alters immunophenotype and survival from sepsis.
Katherine T Fay, et al.
FASEB J. 2019 Oct;33(10):11258-11269. doi: 10.1096/fj.201802188R. Epub 2019 Jul 15.
テーマ：病院前診療における除細動戦略〔担当 岸本真治〕
Initial Defibrillator Pad Position and Outcomes for Shockable Out-of-Hospital Cardiac Arrest.
Joshua R Lupton, et al.
JAMA Netw Open. 2024 Sep 3;7(9):e2431673. doi: 10.1001/jamanetworkopen.2024.31673.
The impact of double sequential shock timing on outcomes during refractory out-of-hospital cardiac arrest.
Mahbod Rahimi , et al.
Resuscitation. 2024 Jan:194:110082. doi: 10.1016/j.resuscitation.2023.110082. Epub 2023 Dec 11.
Defibrillation Strategies for Refractory Ventricular Fibrillation.
Sheldon Cheskes, et al.
N Engl J Med. 2022 Nov 24;387(21):1947-1956. doi: 10.1056/NEJMoa2207304. Epub 2022 Nov 6.
【2024.9.9】
テーマ：重症患者の栄養療法：タンパク質投与量〔担当 大島拓〕
Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands.
Julia L M Bels, et al.
Lancet. 2024 Aug 17;404(10453):659-669. doi: 10.1016/S0140-6736(24)01304-7.
栄養療法の最適化を目指すモニタリング.
大島拓.
日集中医誌 2024;31:253-60.
Nutritional therapy for the prevention of post-intensive care syndrome.
Taku Oshima, et al.
J Intensive Care. 2024 Jul 29;12(1):29. doi: 10.1186/s40560-024-00734-2.
Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis.
Taku Oshima, et al.
Clin Nutr. 2016 Aug;35(4):968-74. doi: 10.1016/j.clnu.2015.10.016. Epub 2015 Nov 7.
テーマ：ERにおける重症患者ケアプログラム導入の効果〔担当 秦奈々美〕
Association of an Emergency Critical Care Program With Survival and Early Downgrade Among Critically Ill Medical Patients in the Emergency Department.
Tsuyoshi Mitarai, et al.
Crit Care Med. 2023 Jun 1;51(6):731-741. doi: 10.1097/CCM.0000000000005835. Epub 2023 Apr 3.
【2024.9.2】
テーマ：フレイル・アミノ酸・genotype〔担当 中田孝明〕
Frailty in Older Adults.
Dae Hyun Kim, et al.
N Engl J Med. 2024 Aug 8;391(6):538-548. doi: 10.1056/NEJMra2301292.
A Randomized Trial of Intravenous Amino Acids for Kidney Protection.
Giovanni Landoni, et al.
N Engl J Med. 2024 Aug 22;391(8):687-698. doi: 10.1056/NEJMoa2403769. Epub 2024 Jun 12.
From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.
Anthony C Gordon, et al.
Am J Respir Crit Care Med. 2024 Jul 15;210(2):155-166. doi: 10.1164/rccm.202311-2086SO.
テーマ：急性呼吸不全のCOVID-19患者に対する覚醒下臥位体位の延長 vs 短時間：多施設共同無作為化比較試験〔担当 馬渡千晴〕
Prolonged vs shorter awake prone positioning for COVID-19 patients with acute respiratory failure: a multicenter, randomised controlled trial.
Ling Liu, et al.
Intensive Care Med. 2024 Aug;50(8):1298-1309. doi: 10.1007/s00134-024-07545-x. Epub 2024 Aug 1.
【2024.8.26】
テーマ：小児の肺移植とECMO for bridge to transplantation〔担当 服部憲幸〕
Mortality after Lung Transplantation for Children Bridged with Extracorporeal Membrane Oxygenation.
Kyle Thompson, et al.
Ann Am Thorac Soc. 2022 Mar;19(3):415-423. doi: 10.1513/AnnalsATS.202103-250OC.
Back to the roots? Dual cannulation strategy for ambulatory ECMO in adolescent lung transplant candidates: An alternative?
F Schmidt, et al.
Pediatr Transplant. 2017 Jun;21(4). doi: 10.1111/petr.12907. Epub 2017 Mar 1.
テーマ：CKDのある敗血症患者に対する輸液管理について〔担当 田﨑康太郎〕
Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial.
Anselm Jorda,et al.
Crit Care. 2024 Jul 11;28(1):231. doi: 10.1186/s13054-024-05019-6.
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network; Nathan I Shapiro, et al.
N Engl J Med. 2023 Feb 9;388(6):499-510. doi: 10.1056/NEJMoa2212663. Epub 2023 Jan 21.
【2024.7.22】
テーマ：重症患者に対するプロトンポンプ阻害薬の投与と中止の判断〔担当 大網毅彦〕
Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation.
Deborah Cook, et al.
N Engl J Med. 2024 Jul 4;391(1):9-20. doi: 10.1056/NEJMoa2404245. Epub 2024 Jun 14.
Timely Cessation of Proton Pump Inhibitors in Critically Ill Patients Impacts Morbidity and Mortality: A Propensity Score-Matched Cohort Study.
Lars Palmowski, et al.
Crit Care Med. 2024 Feb 1;52(2):190-199. doi: 10.1097/CCM.0000000000006104. Epub 2024 Jan 19.
テーマ：重症成人の挿管前酸素化におけるNIVの有効性について〔担当 鈴木俊将〕
Noninvasive Ventilation for Preoxygenation during Emergency Intubation.
Kevin W Gibbs, et al,
N Engl J Med. 2024 Jun 20;390(23):2165-2177. doi: 10.1056/NEJMoa2313680. Epub 2024 Jun 13.
【2024.7.8】
テーマ：irAEとCRS〔担当 大村拓〕
Effects of immune-related adverse events (irAEs) and their treatment on antitumor immune responses.
Steven M Blum, et al.
Immunol Rev. 2023 Sep;318(1):167-178. doi: 10.1111/imr.13262. Epub 2023 Aug 14.
Immune-Related Adverse Events (irAEs): Diagnosis, Management, and Clinical Pearls.
Eli P Darnell, et al.
Curr Oncol Rep. 2020 Mar 21;22(4):39. doi: 10.1007/s11912-020-0897-9.
Cytokine release syndrome and cancer immunotherapies – historical challenges and promising futures.
Deep Shah, et al.
Front Immunol. 2023 May 25:14:1190379. doi: 10.3389/fimmu.2023.1190379. eCollection 2023.
Prevention and management of adverse events during treatment with bispecific antibodies and CAR T cells in multiple myeloma: a consensus report of the European Myeloma Network.
Heinz Ludwig, et al.
Lancet Oncol. 2023 Jun;24(6):e255-e269. doi: 10.1016/S1470-2045(23)00159-6.
Cytokine Storm.
David C Fajgenbaum, et al.
N Engl J Med. 2020 Dec 3;383(23):2255-2273. doi: 10.1056/NEJMra2026131.
テーマ：誤嚥性肺炎における嫌気性カバー抗菌薬の適用範囲と関連する利点および欠点:後ろ向きコホート研究〔担当 福味徹也〕
Anaerobic Antibiotic Coverage in Aspiration Pneumonia and the Associated Benefits and Harms: A Retrospective Cohort Study.
Anthony D Bai, et al.
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.
【2024.7.1】
テーマ：蘇生後脳症に対するグレリン投与〔担当 砂原聡〕
Ghrelin for Neuroprotection in Post-Cardiac Arrest Coma: A Randomized Clinical Trial.
Sjoukje Nutma et al.
JAMA Neurol. 2024 Jun 1;81(6):603-610. doi: 10.1001/jamaneurol.2024.1088.
テーマ：敗血症患者における維持液減量プロトコル群vs通常治療群の輸液投与量
の比較〔担当 中尾漱〕
Protocolized reduction of non-resuscitation fluids versus usual care in septic shock patients (REDUSE): a randomized multicentre feasibility trial.
Anja Lindén et al.
Crit Care. 2024 May 17;28(1):166. doi: 10.1186/s13054-024-04952-w.
【2024.6.24】
テーマ：臓器提供に向けた患者管理〔担当 富田啓介〕
Evidence-Based Checklist to Delay Cardiac Arrest in Brain-Dead Potential Organ Donors: The DONORS Cluster Randomized Clinical Trial.
Glauco A Westphal, et al.
JAMA Netw Open. 2023 Dec 1;6(12):e2346901.
テーマ：敗血症に対する抗菌薬の持続投与と間欠投与の比較〔担当 小松浩一郎〕
Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis: The BLING III Randomized Clinical Trial.
Joel M Dulhunty, et al.
JAMA. 2024 Jun 12:e249779. doi: 10.1001/jama.2024.9779. Online ahead of print.
【2024.6.17】
テーマ：第Xa因子阻害剤中和剤の有効性〔担当 今枝太郎〕
Andexanet for Factor Xa Inhibitor-Associated Acute Intracerebral Hemorrhage.
Stuart J Connolly, et al.
N Engl J Med. 2024 May 16;390(19):1745-1755. doi: 10.1056/NEJMoa2313040.
Reversing Oral Anticoagulation in Intracerebral Hemorrhage.
Wade S Smith, et al.
N Engl J Med. 2024 May 16;390(19):1815-1816. doi: 10.1056/NEJMe2403726.
テーマ：敗血症におけるアセトアミノフェンの臓器不全予防及び治療効果について〔担当 飯島将信〕
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
Lorraine B Ware, et al.
JAMA. 2024 May 19. doi: 10.1001/jama.2024.8772. Online ahead of print.
【2024.6.10】
テーマ：POCUS〔担当 宮内清司〕
IDoes Point-of-Care Ultrasound Affect Fluid Resuscitation Volume in Patients with Septic Shock: A Retrospective Review.
Enyo A Ablordeppey, et al.
Emerg Med Int. 2024 May 6:2024:5675066. doi: 10.1155/2024/5675066. eCollection 2024.
テーマ：外傷患者におけるsigh ventilation〔担当 池邉茉莉〕
Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial.
Richard K Albert, et al.
JAMA. 2023 Nov 28;330(20):1982-1990. doi: 10.1001/jama.2023.21739.
【2024.6.3】
テーマ：脳卒中患者の診断前降圧管理〔担当 池田優〕
Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke.
Gang Li, et al.
N Engl J Med. 2024 May 30;390(20):1862-1872. doi: 10.1056/NEJMoa2314741. Epub 2024 May 16.
テーマ：血小板低下患者におけるCV挿入前の血小板輸血について〔担当 稲益郁〕
Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia.
Floor L F van Baarle, et al.
N Engl J Med. 2023 May 25;388(21):1956-1965. doi: 10.1056/NEJMoa2214322.
【2024.5.27】
テーマ：心筋梗塞による心原性ショックに対するImpella vs 標準治療〔担当 近藤乾伍〕
Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock.
Jacob E Møller, et al.
N Engl J Med. 2024 Apr 18;390(15):1382-1393. doi: 10.1056/NEJMoa2312572. Epub 2024 Apr 7.
テーマ：敗血症性ショックにおける高CVPと死亡率・AKIの関係〔担当 兼松里衣〕
Early persistent exposure to high CVP is associated with increased mortality and AKI in septic shock: A retrospective study.
Wenyan Xiao, et al.
Am J Emerg Med. 2023 Dec:74:146-151. doi: 10.1016/j.ajem.2023.09.043. Epub 2023 Sep 29.
【2024.5.20】
テーマ：敗血症とLowT3症候群〔担当 今田寛〕
Association Between Nonthyroidal Illness Syndrome and Disseminated Intravascular Coagulation in Sepsis.
Yi Yao, et al.
J Inflamm Res. 2024 Jan 28:17:497-506. doi: 10.2147/JIR.S442598. eCollection 2024.
Triiodothyronine hormone supplementation therapy in septic shock patients with euthyroid sick syndrome: two pilot, placebo-controlled, randomized trials.
Mirza Kovacevic, et al.
Anaesth Crit Care Pain Med. 2024 Apr;43(2):101336. doi: 10.1016/j.accpm.2023.101336. Epub 2023 Dec 5.
テーマ：抗凝固薬内服中の脳出血患者における抗凝固薬の拮抗のタイミング〔担当 岸本真治〕
Time to Anticoagulation Reversal and Outcomes After Intracerebral Hemorrhage.
Kevin N Sheth, et al.
JAMA Neurol. 2024 Feb 9;81(4):363-372. doi: 10.1001/jamaneurol.2024.0221. Online ahead of print.
【2024.5.13】
テーマ：小児の敗血症〔担当 石田茂誠〕
International Consensus Criteria for Pediatric Sepsis and Septic Shock.
Luregn J Schlapbach, et al.
JAMA. 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179.
テーマ：敗血症性心筋症の予後予測因子〔担当 秦奈々美〕
Identifying predictors and determining mortality rates of septic cardiomyopathy and sepsis-related cardiogenic shock: A retrospective, observational study.
Kathryn W Hendrickson, et al.
PLoS One. 2024 Apr 25;19(4):e0299876. doi: 10.1371/journal.pone.0299876. eCollection 2024.
【2024.4.22】
テーマ：腸内細菌菌血症に対するde escalation〔担当 柄澤智史〕
Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial.
Luis Eduardo López-Cortés, et al.
Lancet Infect Dis. 2024 Apr;24(4):375-385. doi: 10.1016/S1473-3099(23)00686-2. Epub 2024 Jan 9.
テーマ：脳出血に対する外科的介入〔担当 飛世知宏〕
Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage.
Gustavo Pradilla, et al.
N Engl J Med. 2024 Apr 11;390(14):1277-1289. doi: 10.1056/NEJMoa2308440.
【2024.4.15】
テーマ：テクノロジーとAI〔担当 中田孝明〕
Key Issues as Wearable Digital Health Technologies Enter Clinical Care.
Geoffrey S Ginsburg, et al.
N Engl J Med. 2024 Mar 21;390(12):1118-1127. doi: 10.1056/NEJMra2307160.
Use of artificial intelligence in critical care: opportunities and obstacles.
Michael R Pinsky, et al.
Crit Care. 2024 Apr 8;28(1):113. doi: 10.1186/s13054-024-04860-z.
Outcome prediction of cardiac arrest with automatically computed gray-white matter ratio on computed tomography images.
Hsinhan Tsai, et al.
Crit Care. 2024 Apr 9;28(1):118. doi: 10.1186/s13054-024-04895-2.
テーマ：院外心停止に対するアドレナリン投与と高度な気道確保のタイミング〔担当 山本晃之〕
Sequence of Epinephrine and Advanced Airway Placement After Out-of-Hospital Cardiac Arrest.
Masashi Okubo, et al.
JAMA Netw Open. 2024 Feb 5;7(2):e2356863. doi: 10.1001/jamanetworkopen.
2023.56863.
【2024.4.8】
テーマ：人工呼吸患者の酸素投与目標〔担当 大島拓〕
Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults.
Kevin G Buell, et al.
JAMA. 2024 Mar 19:e242933. doi: 10.1001/jama.2024.2933. Online ahead of print.
Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial.
Frederik M Nielsen, et al.
JAMA. 2024 Mar 19:e242934. doi: 10.1001/jama.2024.2934. Online ahead of print.
テーマ：抜管時の基準別の抜管までの日数・再挿管率の検討〔担当 馬場彩夏〕
Effect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trial.
Gonzalo Hernández Martínez, et al.
Intensive Care Med. 2024 Feb;50(2):258-267. doi: 10.1007/s00134-024-07330-w. Epub 2024 Feb 14.
【2024.3.18】
テーマ：ARDSの高炎症性サブフェノタイプ〔担当 砂原聡〕
Inflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trial.
Simone Redaelli, et al.
Intensive Care Med. 2023 Dec;49(12):1499-1507. doi: 10.1007/s00134-023-07244-z. Epub 2023 Oct 31.
テーマ：敗血症による末梢組織低灌流に対するアルブミン投与vs生理食塩水投与〔担当 近藤乾伍〕
Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study.
Paul Gabarre, et al.
Crit Care. 2024 Feb 7;28(1):43. doi: 10.1186/s13054-024-04827-0.
【2024.3.11】
テーマ：VAPに対する抗菌薬〔担当 今枝太郎〕
Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial.
Claire Dahyot-Fizelier, et al.
Lancet Respir Med. 2024 Jan 19:S2213-2600(23)00471-X. doi: 10.1016/S2213-2600(23)00471-X. Online ahead of print.
Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial.
Yin Mo, et al.
Lancet Respir Med. 2024 Jan 22:S2213-2600(23)00418-6. doi: 10.1016/S2213-2600(23)00418-6. Online ahead of print.
テーマ：院内心停止における、心肺蘇生時間1分ごとの患者転帰との関連〔担当 篠原雅貴〕
Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study.
Masashi Okubo, et al.
BMJ. 2024 Feb 7:384:e076019. doi: 10.1136/bmj-2023-076019.
【2024.3.4】
テーマ：GNR菌血症の抗菌薬投与期間〔担当 柄澤智史〕
Duration of antibiotic treatment for Gram-negative bacteremia - Systematic review and individual participant data (IPD) meta-analysis.
Adi Turjeman, et al.
EClinicalMedicine. 2022 Dec 1:55:101750. doi: 10.1016/j.eclinm.2022. 101750. eCollection 2023 Jan.
Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial.
Adrien Bouglé, et al.
Intensive Care Med. 2022 Jul;48(7):841-849. doi: 10.1007/s00134-022-06690-5. Epub 2022 May 13.
Seven Versus 14 Days of Antibiotic Therapy for Uncomplicated Gram- negative Bacteremia: A Noninferiority Randomized Controlled Trial.
Dafna Yahav, et al.
Clin Infect Dis. 2019 Sep 13;69(7):1091-1098. doi: 10.1093/cid/ciy1054.
Effect of C-Reactive Protein-Guided Antibiotic Treatment Duration, 7-Day Treatment, or 14-Day Treatment on 30-Day Clinical Failure Rate in Patients With Uncomplicated Gram-Negative Bacteremia: A Randomized Clinical Trial
Elodie von Dach, et al.
JAMA. 2020 Jun 2;323(21):2160-2169. doi: 10.1001/jama.2020.6348.
テーマ：急性中毒による昏睡患者に対する非侵襲的気道管理の効果〔担当 斉藤千宙〕
Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial.
Yonathan Freund, et al.
JAMA. 2023 Dec 19;330(23):2267-2274. doi: 10.1001/jama.2023.24391.
【2024.2.26】
テーマ：ProtekDuo〔担当 服部憲幸〕
ProtekDuo percutaneous ventricular support system-physiology and clinical applications.
Kevin John John, et al.
Ann Transl Med. 2024 Feb 1;12(1):14. doi: 10.21037/atm-23-1734. Epub2023 Dec 4.
Safety and efficacy of ProtekDuo right ventricular assist device: A systemic review.
Amit Alam, et al.
Artif Organs. 2023 Jul;47(7):1094-1103. doi: 10.1111/aor.14525. Epub2023 Apr 3.
テーマ：喀血に対するトラネキサム酸のネブライザーについて〔担当 加納時定〕
Nebulized vs IV Tranexamic Acid for Hemoptysis: A Pilot Randomized Controlled Trial.
Bharath Gopinath, et al.
Chest. 2023 May;163(5):1176-1184. doi: 10.1016/j.chest.2022.11.021. Epub 2022 Nov 19.
【2024.2.19】
テーマ：セフェピム脳症〔担当 島田忠長〕
Cefepime-induced neurotoxicity: a systematic review.
Lauren E Payne, et al.
Crit Care. 2017 Nov 14;21(1):276. doi: 10.1186/s13054-017-1856-1.
Cefepime-induced neurotoxicity: systematic review.
Gozun Maan, et al.
J Antimicrob Chemother. 2022 Oct 28;77(11):2908-2921. doi: 10.1093/jac/dkac271.
テーマ：急性期ICUせん妄患者に対するハロペリドールとプラセボの長期転機について〔担当 松浦夏帆〕
Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with delirium.
Camilla Bekker Mortensen, et al.
Intensive Care Med. 2024 Jan;50(1):103-113. doi: 10.1007/s00134-023-07282-7. Epub 2024 Jan 3.
【2024.2.5】
テーマ：小児重症患者に対するSpO2の目標値〔担当 大網毅彦〕
Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomized clinical trial.
Mark J Peters, et al.
Lancet. 2024 Jan 27;403(10424):355-364. doi: 10.1016/S0140-6736(23)01968-2. Epub 2023 Dec 1.
テーマ：除菌による感染症予防効果〔担当 池田優〕
Decolonization in Nursing Homes to Prevent Infection and Hospitalization.
Loren G Miller, et al.
N Engl J Med. 2023 Nov 9;389(19):1766-1777. doi: 10.1056/NEJMoa2215254. Epub 2023 Oct 10.
【2024.1.29】
テーマ：CTRXとPPI〔担当 富田啓介〕
Adverse Safety Events in Emergency Medical Services Care of Children With Out-of-Hospital Cardiac Arrest.
Carl O Eriksson, et al.
JAMA Netw Open. 2024 Jan 2;7(1):e2351535. doi: 10.1001/jamanetworkopen.2023.51535.
テーマ：非ショック性心停止における非侵襲的補助装置と頭胸部挙上〔担当 秦奈々美〕
Survival for Nonshockable Cardiac Arrests Treated With Noninvasive Circulatory Adjuncts and Head/Thorax Elevation.
Kerry M Bachista, et al.
Crit Care Med. 2024 Feb 1;52(2):170-181. doi: 10.1097/CCM.0000000000006055. Epub 2024 Jan 19.
【2024.1.22】
テーマ：ECMO患者の腹臥位療法〔担当 菅なつみ〕
Prone Positioning During Extracorporeal Membrane Oxygenation in Patients With Severe ARDS: The PRONECMO Randomized Clinical Trial.
Matthieu Schmidt, et al.
JAMA. 2023 Dec 26;330(24):2343-2353. doi: 10.1001/jama.2023.24491.
テーマ：小児における安全管理〔担当 宮内清司〕
Adverse Safety Events in Emergency Medical Services Care of Children With Out-of-Hospital Cardiac Arrest.
Carl O Eriksson, et al.
JAMA Netw Open. 2024 Jan 2;7(1):e2351535. doi: 10.1001/jamanetworkopen.2023.51535.
【2024.1.15】
テーマ：敗血症性ショックに対するステロイド投与〔担当 大村拓〕
Do We Need to Administer Fludrocortisone in Addition to Hydrocortisone in Adult Patients With Septic Shock? An Updated Systematic Review With Bayesian Network Meta-Analysis of Randomized Controlled Trials and an Observational Study With Target Trial Emulation.
Pei-Chun Lai, et al.
Crit Care Med. 2023 Dec 29. doi: 10.1097/CCM.0000000000006161. Online ahead of print.
テーマ：VA ECMO患者の年齢と転帰の関係〔担当 馬場彩夏〕
Age and associated outcomes among patients receiving venoarterial extracorporeal membrane oxygenation-analysis of the Extracorporeal Life Support Organization registry.
Shannon M Fernando, et al.
Intensive Care Med. 2023 Dec;49(12):1456-1466. doi: 10.1007/s00134-023-07199-1. Epub 2023 Oct 4.
De senectute and the art of medicine: how old is too old for ECMO in cardiogenic shock?
Jordi Riera, et al.
Intensive Care Med. 2023 Dec;49(12):1511-1513. doi: 10.1007/s00134-023-07251-0. Epub 2023 Nov 3.
2023年
【2023.12.18】
テーマ：RSV mRNAワクチン・酸素療法・抗菌薬・脳損傷と非侵襲的呼吸サポート〔担当 中田孝明〕
Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults.
Eleanor Wilson, et al.
N Engl J Med. 2023 Dec 14;389(24):2233-2244. doi: 10.1056/NEJMoa2307079.
Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial.
L Imeen van der Wal, et al.
Am J Respir Crit Care Med. 2023 Oct 1;208(7):770-779. doi: 10.1164/rccm.202303-0560OC.
Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial.
Edward T Qian, et al.
JAMA. 2023 Oct 24;330(16):1557-1567. doi: 10.1001/jama.2023.20583.
Association of Noninvasive Respiratory Support with Extubation Outcomes in Brain-injured Patients Receiving Mechanical Ventilation: A Secondary Analysis of the ENIO Prospective Observational Study.
Shaurya Taran, et al.
Am J Respir Crit Care Med. 2023 Aug 1;208(3):270-279. doi: 10.1164/rccm.202212-2249OC.
テーマ：小児患者におけるビデオ喉頭鏡の有用性〔担当 石田茂誠〕
Implementation of Video Laryngoscope-Assisted Coaching Reduces Adverse Tracheal Intubation-Associated Events in the PICU.
John Giuliano Jr, et al.
Crit Care Med. 2023 Jul 1;51(7):936-947. doi: 10.1097/CCM.0000000000005847. Epub 2023 Mar 27.
【2023.12.11】
テーマ：重症患者の栄養療法:継続性について〔担当 大島拓〕
Continued enteral nutrition until extubation compared with fasting before extubation in patients in the intensive care unit: an open-label, cluster-randomised, parallel-group, non-inferiority trial.
Mickaël Landais, et al.
Lancet Respir Med. 2023 Apr;11(4):319-328. doi: 10.1016/S2213-2600(22)00413-1. Epub 2023 Jan 21.
The role of nutrition rehabilitation in the recovery of survivors of critical illness: underrecognized and underappreciated.
Lesley L Moisey, et al.
Crit Care. 2022 Sep 8;26(1):270. doi: 10.1186/s13054-022-04143-5.
テーマ：心筋梗塞患者の輸血戦略〔担当 飛世知宏〕
Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia.
Jeffrey L Carson, et al.
N Engl J Med. 2023 Nov 11. doi: 10.1056/NEJMoa2307983. Online ahead of print.
【2023..12.4】
テーマ：FilmArray®（髄液）の有用性〔担当 砂原聡〕
Outcomes of implementation of the FilmArray meningoencephalitis panel in a tertiary hospital between 2017 and 2020.
TeeKeat Teoh, et al.
PLoS One. 2022 Mar 17;17(3):e0265187. doi: 10.1371/journal.pone.0265187. eCollection 2022.
テーマ：REBOA〔担当 山本晃之〕
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial.
Jan O Jansen, et al.
JAMA. 2023 Nov 21;330(19):1862-1871. doi: 10.1001/jama.2023.20850.
【2023.11.27】
テーマ：敗血症性頻脈性不整脈の治療〔担当 今枝太郎〕
Landiolol and Organ Failure in Patients With Septic Shock: The STRESS-L Randomized Clinical Trial.
Tony Whitehouse, et al.
JAMA. 2023 Nov 7;330(17):1641-1652. doi: 10.1001/jama.2023.20134.
Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial.
Martin Balik, et al.
Intensive Care Med. 2023 Nov;49(11):1283-1292. doi: 10.1007/s00134-023-07208-3. Epub 2023 Sep 12.
テーマ：ノルアドレナリンの末梢投与はCV留置の頻度を減らすことができるか〔担当 篠原雅貴〕
Peripheral Administration of Norepinephrine: A Prospective Observational Study.
Jason R Yerke, et al.
Chest. 2023 Aug 21:S0012-3692(23)05350-3. doi: 10.1016/j.chest.2023.08.019. Online ahead of print.
【2023.11.20】
テーマ：肥満へのECMO〔担当 柄澤智史〕
Mortality in Patients with Obesity and Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation: The Multicenter ECMObesity Study.
Darya Rudym, et al.
Am J Respir Crit Care Med. 2023 Sep 15;208(6):685-694. doi: 10.1164/rccm.202212-2293OC.
Impact of BMI on outcomes in respiratory ECMO: an ELSO registry study.
Marijke Peetermans, et al.
Intensive Care Med. 2023 Jan;49(1):37-49. doi: 10.1007/s00134-022-06926-4. Epub 2022 Nov 22.
テーマ：集中治療における輸血を減らすための小容量採血管〔担当 斉藤千宙〕
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care: The STRATUS Randomized Clinical Trial.
Deborah M Siegal, et al.
JAMA. 2023 Oct 12:e2320820. doi: 10.1001/jama.2023.20820. Online ahead of print.
【2023.11.13】
テーマ：小児の血液浄化〔担当 服部憲幸〕
The Infant KIdney Dialysis and Utrafiltration (I-KID) Study: A Stepped-Wedge Cluster-Randomized Study in Infants, Comparing Peritoneal Dialysis, Continuous Venovenous Hemofiltration, and Newcastle Infant Dialysis Ultrafiltration System, a Novel Infant Hemodialysis Device.
Heather Lambert, et al.
Pediatr Crit Care Med. 2023 Jul 1;24(7):604-613. doi: 10.1097/PCC.0000000000003220. Epub 2023 Mar 9.
Haemodialysing babies weighing
Malcolm G Coulthard, et al.
Pediatr Nephrol. 2014 Oct;29(10):1873-81. doi: 10.1007/s00467-014-2923-3. Epub 2014 Aug 15.
Comparison of nafamostat mesilate to citrate anticoagulation in pediatric continuous kidney replacement therapy.
Mai J Miyaji, et al.
Pediatr Nephrol. 2022 Nov;37(11):2733-2742. doi: 10.1007/s00467-022-05502-8. Epub 2022 Mar 28.
テーマ：敗血症の初回抗菌薬治療 カルバペネム系と非カルバペネム系の比較〔担当 松浦夏帆〕
Efficacy of Carbapenems Compared With Noncarbapenem Broad-Spectrum Beta-Lactam Antibiotics as Initial Antibiotic Therapy Against Sepsis: A Nationwide Observational Study.
Yutaka Umemura, et al.
Crit Care Med. 2023 Sep 1;51(9):1210-1221. doi: 10.1097/CCM.0000000000005932. Epub 2023 May 26.
【2023.11.6】
テーマ：第13因子〔担当 島田忠長〕
The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing.
Christian Kleber, et al.
Crit Care. 2022 Mar 24;26(1):69. doi: 10.1186/s13054-022-03940-2.
Factor XIII in the Acute Care Setting and Its Relevance in Obstetric Bleeding.
Patricia Duque, et al.
Transfus Med Hemother. 2022 Nov 24;50(1):10-17. doi: 10.1159/000526489. eCollection 2023 Feb.
テーマ：早期の経静脈栄養を使用していないICU患者の血糖管理について〔担当 加納時定〕
Tight Blood-Glucose Control without Early Parenteral Nutrition in the ICU.
Jan Gunst, et al.
N Engl J Med. 2023 Sep 28;389(13):1180-1190. doi: 10.1056/NEJMoa2304855.
【2023.10.30】
テーマ：抗菌薬吸入療法によるVAPの予防〔担当 大網毅彦〕
Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia.
Stephan Ehrmann, et al.
N Engl J Med. 2023 Oct 25. doi: 10.1056/NEJMoa2310307. Online ahead of print.
Aerosolised antibiotics in critical care.
Jordi Rello, et al.
Intensive Care Med. 2023 Jul;49(7):848-852. doi: 10.1007/s00134-023-07036-5. Epub 2023 Apr 21.
【2023.10.23】
テーマ：ARDS〔担当 富田啓介〕
ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Giacomo Grasselli, et al.
Intensive Care Med. 2023 Jul;49(7):727-759. doi: 10.1007/s00134-023-07050-7. Epub 2023 Jun 16.
テーマ：COPD急性増悪とVTE〔担当 池田優〕
Prevalence, Risk Factor and Clinical Characteristics of Venous Thrombus Embolism in Patients with Acute Exacerbation of COPD: A Prospective Multicenter Study.
Xia Liu, et al.
Int J Chron Obstruct Pulmon Dis. 2023 May 18:18:907-917. doi: 10.2147/COPD.S410954. eCollection 2023.
【2023.10.16】
テーマ：腹臥位療法〔担当 菅なつみ〕
Impact of Prone Position in COVID-19 Patients on Extracorporeal Membrane Oxygenation.
Nicolas Massart, et al.
Crit Care Med. 2023 Jan 1;51(1):36-46. doi: 10.1097/CCM.0000000000005714. Epub 2022 Nov 11.
Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis.
Laurent Papazian, et al.
Intensive Care Med. 2022 Mar;48(3):270-280. doi: 10.1007/s00134-021-06604-x. Epub 2022 Jan 17.
Prone position in mechanically ventilated patients.
Laurent Papazian, et al.
Intensive Care Med. 2022 Aug;48(8):1062-1065. doi: 10.1007/s00134-022-06731-z. Epub 2022 Jun 2.
テーマ：Rapid Sequence Intubation〔担当 宮内清司〕
Society of Critical Care Medicine Clinical Practice Guidelines for Rapid Sequence Intubation in the Critically Ill Adult Patient.
Nicole M Acquisto, et al.
Crit Care Med. 2023 Oct 1;51(10):1411-1430. doi: 10.1097/CCM.0000000000006000. Epub 2023 Sep 14.
【2023.10.2】
テーマ：敗血症性ショックの血圧管理〔担当 大村拓〕
The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study.
Kensuke Nakamura, et al.
Crit Care. 2023 Jul 21;27(1):294. doi: 10.1186/s13054-023-04583-7.
テーマ：心筋梗塞関連の心原性ショックに対するECMO〔担当 秦奈々美〕
Extracorporeal Life Support in Infarct-Related Cardiogenic Shock.
Holger Thiele, et al.
N Engl J Med. 2023 Aug 26. doi: 10.1056/NEJMoa2307227. Online ahead of print.
【2023.9.25】
テーマ：AI・不眠症と敗血症・COVIDとACE阻害・脳低温療法・ヒストン中和〔担当 中田孝明〕
AI
Artificial Intelligence in U.S. Health Care Delivery.
Nikhil R Sahni, et al.
N Engl J Med. 2023 Jul 27;389(4):348-358. doi: 10.1056/NEJMra2204673.
不眠症と敗血症
Association of Genetically Predicted Insomnia With Risk of Sepsis: A Mendelian Randomization Study.
Marianne S Thorkildsen, et al.
JAMA Psychiatry. 2023 Aug 9;e232717. doi: 10.1001/jamapsychiatry.2023.2717. Online ahead of print.
COVIDとACE阻害
Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators; Patrick R Lawler, et al.
JAMA. 2023 Apr 11;329(14):1183-1196. doi: 10.1001/jama.2023.4480.
脳低温療法
Changes in Practice of Controlled Hypothermia after Cardiac Arrest in the Past 20 Years: A Critical Care Perspective.
Niklas Nielsen, et al.
Am J Respir Crit Care Med. 2023 Jun 15;207(12):1558-1564. doi: 10.1164/rccm.202211-2142CP.
ヒストン中和
Clusterin Neutralizes the Inflammatory and Cytotoxic Properties of Extracellular Histones in Sepsis.
Jean-François Augusto, et al.
Am J Respir Crit Care Med. 2023 Jul 15;208(2):176-187. doi: 10.1164/rccm.202207-1253OC.
テーマ：ジルチアゼムの心房細動治療における血清Ca濃度との関係〔担当 馬場彩夏〕
The effect of serum calcium level on the success of diltiazem treatment: A retrospective cohort study.
Safa Hüseyin Küçük, et al.
Am J Emerg Med. 2023 Sep;71:59-62. doi: 10.1016/j.ajem.2023.06.007. Epub 2023 Jun 10.
【2023.9.11】
テーマ：重症患者に対する栄養療法〔担当 大島拓〕
Personalized nutrition therapy in critical care: 10 expert recommendations.
Paul E Wischmeyer, et al.
Crit Care. 2023 Jul 4;27(1):261. doi: 10.1186/s13054-023-04539-x.
Controlled enteral nutrition in critical care patients - A randomized clinical trial of a novel management system.
Ilya Kagan, et al.
Clin Nutr. 2023 Sep;42(9):1602-1609. doi: 10.1016/j.clnu.2023.06.018. Epub 2023 Jul 7.
テーマ：小児の心補助デバイス〔担当 田中麻須美〕
Outcomes of temporary ventricular assist device: A pediatric institutional experience over 25 years.
Junsang Cho, et al.
J Thorac Cardiovasc Surg. 2023 Jul;166(1):201-211.e2. doi: 10.1016/j.jtcvs.2022.10.041. Epub 2022 Nov 4.
【2023.9.4】
テーマ：敗血症とmicroRNA〔担当 砂原聡〕
Role of miRNA dysregulation in sepsis.
Amanda Formosa, et al.
Mol Med. 2022 Aug 19;28(1):99. doi: 10.1186/s10020-022-00527-z.
テーマ：小児の呼吸器離脱〔担当 石田茂誠〕
Executive Summary: International Clinical Practice Guidelines for Pediatric Ventilator Liberation, A Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Document.
Samer Abu-Sultaneh, et al.
Am J Respir Crit Care Med. 2023 Jan 1;207(1):17-28. doi: 10.1164/rccm.202204-0795SO.
【2023.8.28】
テーマ：気管挿管〔担当 今枝太郎〕
Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults.
Matthew E Prekker, et al.
N Engl J Med. 2023 Aug 3;389(5):418-429. doi: 10.1056/NEJMoa2301601. Epub 2023 Jun 16.
Video Laryngoscopy for Intubation - Time for a New Paradigm?
Yonathan Freund, et al.
N Engl J Med. 2023 Aug 3;389(5):472-473. doi: 10.1056/NEJMe2305596. Epub 2023 Jun 16.
テーマ：外傷急性期の赤血球輸血〔担当 飛世知宏〕
The Restrictive Red Blood Cell Transfusion Strategy for Critically Injured Patients (RESTRIC) trial: a cluster-randomized, crossover, non-inferiority multicenter trial of restrictive transfusion in trauma.
Mineji Hayakawa, et al.
J Intensive Care. 2023 Jul 24;11(1):34. doi: 10.1186/s40560-023-00682-3.
【2023.7.24】
テーマ：蘇生後呼吸器管理〔担当 柄澤智史〕
Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest.
Glenn Eastwood, et al.
N Engl J Med. 2023 Jul 6;389(1):45-57. doi: 10.1056/NEJMoa2214552. Epub 2023 Jun 15.
テーマ：重症外傷に対するトラネキサム酸投与と機能的予後〔担当 山本晃之〕
Prehospital Tranexamic Acid for Severe Trauma.
PATCH-Trauma Investigators and the ANZICS Clinical Trials Group; Russell. L Gruen, et al.
N Engl J Med. 2023 Jul 13;389(2):127-136. doi: 10.1056/NEJMoa2215457. Epub 2023 Jun 14.
【2023.7.10】
テーマ：ECMOと中枢神経障害〔担当 服部憲幸〕
Hypoxic-Ischemic Brain Injury in ECMO: Pathophysiology, Neuromonitoring, and Therapeutic Opportunities.
Shivalika Khanduja, et al.
Cells. 2023 Jun 5;12(11):1546. doi: 10.3390/cells12111546.
テーマ：重症敗血症にメロペネム持続投与は有効か〔担当 篠崎雅貴〕
Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial.
Giacomo Monti, et al.
JAMA. 2023 Jun 16;e2310598. doi: 10.1001/jama.2023.10598. Online ahead of print.
【2023.7.3】
テーマ：HDLとその機能〔担当 島田忠長〕
HDL in the 21st Century: A Multifunctional Roadmap for Future HDL Research.
Anand Rohatgi, et al.
Circulation. 2021 Jun 8;143(23):2293-2309. doi: 10.1161/CIRCULATIONAHA.120.044221. Epub 2021 Jun 7.
テーマ：COVID-19パンデミック下におけるOHCAの神経予後の変化〔担当 加納時定〕
Changes in neurological outcomes of out-of-hospital cardiac arrest during the COVID-19 pandemic in Japan: a population-based nationwide observational study.
Aya Katasako, et al.
Lancet Reg Health West Pac. 2023 May 2;100771. doi: 10.1016/j.lanwpc. 2023.100771. Online ahead of print.
【2023.6.26】
テーマ：乏尿の定義〔担当 大網毅彦〕
Identification of an optimal threshold to define oliguria in critically ill patients: an observational study.
Nathan Axel Bianchi, et al.
Crit Care. 2023 May 30;27(1):207. doi: 10.1186/s13054-023-04505-7.
Machine learning for diagnosis of myocardial infarction using cardiac troponin concentrations.
Dimitrios Doudesis, et al.
Nat Med. 2023 May;29(5):1201-1210. doi: 10.1038/s41591-023-02325-4. Epub 2023 May 11.
テーマ：大量輸血のリスクを有する患者における4F-PCCの使用の有効性と安全性について〔担当 斉藤千宙〕
Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.
Pierre Bouzat, et al.
JAMA. 2023 Apr 25;329(16):1367-1375. doi: 10.1001/jama.2023.4080.
【2023.6.19】
テーマ：Burnout〔担当 齋藤大輝〕
Burnout among Japanese emergency medicine physicians: A multicentric questionnaire study.
Miki Morikawa, et al.
Acute Med Surg. 2023 May 31;10(1):e848. doi: 10.1002/ams2.848. eCollection 2023 Jan-Dec.
テーマ：市中肺炎でICUに入院する患者の長期的死亡率に対するマクロライド治療の影響〔担当 松浦夏帆〕
Impact of macrolide treatment on long-term mortality in patients admitted to the ICU due to CAP: a targeted maximum likelihood estimation and survival analysis.
Luis Felipe Reyes, et al.
Crit Care. 2023 May 31;27(1):212. doi: 10.1186/s13054-023-04466-x.
【2023.6.12】
テーマ：リハビリテーション〔担当 富田啓介〕
Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial.
Bhakti K Patel, et al.
Lancet Respir Med. 2023 Jun;11(6):563-572. doi: 10.1016/S2213-2600(22)00489-1. Epub 2023 Jan 21.
Early mobilisation during critical illness: good for the body and brain.
Timothy D Girard, et al.
Lancet Respir Med. 2023 Jun;11(6):500-502. doi: 10.1016/S2213-2600(23)00011-5. Epub 2023 Jan 25.
テーマ：デクスメデトミジンと新規発症心房細動〔担当 三輪弥生〕
Association of Dexmedetomidine With New-Onset Atrial Fibrillation in Patients With Critical Illness.
Myung Jin Song, et al.
JAMA Netw Open. 2023 Apr 3;6(4):e239955. doi: 10.1001/jamanetworkopen.2023.9955.
【2023.6.5】
テーマ：V-V ECMO中のRBC輸血について〔担当者 菅なつみ〕
Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study.
Gennaro Martucci, et al.
Lancet Respir Med. 2023 Mar;11(3):245-255. doi: 10.1016/S2213-2600(22)00353-8. Epub 2022 Oct 11.
テーマ：心原性ショックに対するVA-ECMO導入時期についての検討〔担当 宮原杏奈〕
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial.
Petr Ostadal, et al.
Circulation. 2023 Feb 7;147(6):454-464. doi: 10.1161/CIRCULATIONAHA.122.062949. Epub 2022 Nov 6.
【2023.5.29】
テーマ：①血小板②PICS③AI〔担当 中田孝明〕
Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia.
Floor L F van Baarle, et al.
N Engl J Med. 2023 May 25;388(21):1956-1965. doi: 10.1056/NEJMoa2214322.
Outcomes after Critical Illness.
Margaret S Herridge, et al.
N Engl J Med. 2023 Mar 9;388(10):913-924. doi: 10.1056/NEJMra2104669.
Benefits, Limits, and Risks of GPT-4 as an AI Chatbot for Medicine.
Peter Lee, et al.
N Engl J Med. 2023 Mar 30;388(13):1233-1239. doi: 10.1056/NEJMsr2214184.
ChatGPT is not the solution to physicians' documentation burden.
Carl Preiksaitis, et al.
Nat Med. 2023 May 11. doi: 10.1038/s41591-023-02341-4. Online ahead of print.
The ChatGPT Era: Artificial Intelligence in Emergency Medicine.
Jace C Bradshaw.
Ann Emerg Med. 2023 Jun;81(6):764-765. doi: 10.1016/j.annemergmed.2023.01.022.
ChatGPT and Physicians' Malpractice Risk.
Michelle M Mello, et al.
JAMA Health Forum. 2023 May 5;4(5):e231938. doi: 10.1001/jamahealthforum.2023.1938.
Artificial Intelligence and Machine Learning in Clinical Medicine, 2023.
Charlotte J Haug, et al.
N Engl J Med. 2023 Mar 30;388(13):1201-1208. doi: 10.1056/NEJMra2302038.
テーマ：小児のカフリークテスト〔担当 田中麻須美〕
Pre-Extubation Cuffed Tube Leak Test and Subsequent Post-Extubation Laryngeal Edema: Prospective, Single-Center Evaluation of PICU Patients.
Koji Kanno, et al.
Pediatr Crit Care Med. 2023 May 23. doi: 10.1097/PCC.0000000000003282. Online ahead of print.
【2023.5.22】
テーマ：重症患者に対する早期栄養療法〔担当 大島拓〕
Low versus standard calorie and protein feeding in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3).
Jean Reignier, et al.
Lancet Respir Med. 2023 Mar 20;S2213-2600(23)00092-9. doi: 10.1016/S2213-2600(23)00092-9. Online ahead of print.
Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN).
Martin Matejovic, et al.
Crit Care. 2022 May 18;26(1):143. doi: 10.1186/s13054-022-03997-z.
Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2).
Jean Reignier, et al.
Lancet. 2018 Jan 13;391(10116):133-143. doi: 10.1016/S0140-6736(17)32146-3. Epub 2017 Nov 8.
テーマ：敗血症に対する輸液療法〔担当 池田優〕
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network; Nathan I Shapiro, et al.
N Engl J Med. 2023 Feb 9;388(6):499-510. doi: 10.1056/NEJMoa2212663. Epub 2023 Jan 21.
【2023.5.15】
テーマ：RRT必要性の予測〔担当 砂原聡〕
Predicting the Development of Renal Replacement Therapy Indications by Combining the Furosemide Stress Test and Chemokine (C-C Motif) Ligand 14 in a Cohort of Postsurgical Patients.
Melanie Meersch, et al.
Crit Care Med. 2023 Mar 29. doi: 10.1097/CCM.0000000000005849. Online ahead of print.
テーマ：呼吸筋〔担当 宮内清司〕
Managing respiratory muscle weakness during weaning from invasive ventilation.
Côme Bureau, et al.
Eur Respir Rev. 2023 Apr 5;32(168):220205. doi: 10.1183/16000617.0205-2022. Print 2023 Jun 30.
【2023.5.8】
テーマ：心停止蘇生後の体温管理療法〔担当 今枝太郎〕
Duration of Device-Based Fever Prevention after Cardiac Arrest.
Christian Hassager, et al.
N Engl J Med. 2023 Mar 9;388(10):888-897. doi: 10.1056/NEJMoa2212528. Epub 2022 Nov 6.
Temperature Management after Cardiac Arrest - All In or Fold?
Stephen Bernard, et al.
N Engl J Med. 2023 Mar 9;388(10):941-942. doi: 10.1056/NEJMe2214973.
テーマ：急性心筋梗塞におけるカリウム濃度〔担当 秦奈々美〕
Serum potassium level, variability and in-hospital mortality in acute myocardial infarction.
Xuexue Zhang, et al.
Eur J Clin Invest. 2022 Jul;52(7):e13772. doi: 10.1111/eci.13772. Epub 2022 Mar 22.
【2023.5.1】
テーマ：ECMO/RRT中の抗菌薬濃度〔担当 柄澤智史〕
Antimicrobial Exposures in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation.
Kiran Shekar, et al.
Am J Respir Crit Care Med. 2023 Mar 15;207(6):704-720. doi: 10.1164/rccm.202207-1393OC.
テーマ：重症患者の体液管理〔担当 馬場彩夏〕
Fluid balance control in critically ill patients: results from POINCARE-2 stepped wedge cluster-randomized trial.
Pierre-Edouard Bollaert, et al.
Crit Care. 2023 Feb 21;27(1):66. doi: 10.1186/s13054-023-04357-1.
【2023.4.24】
テーマ：PMMA-hemofilterの海外展開〔担当者 服部憲幸〕
Anti-Inflammatory Approach in Chronic Dialysis Patients with SARS-CoV-2: ATA or PMMA Dialyzers?
Gabriele Donati, et al.
Blood Purif. 2023;52(2):210-218. doi: 10.1159/000526319. Epub 2022 Nov2.
New Frontiers in Sepsis-Induced Acute Kidney Injury and Blood Purification Therapies: The Role of Polymethylmethacrylate Membrane Hemofilter.
Alessandra Stasi, et al.
Blood Purif. 2023 Jan 24;1-14. doi: 10.1159/000528685. Online ahead of print.
テーマ：てんかん重積〔担当 飛世知宏〕
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non- inferiority randomised control trial.
Kensuke Nakamura, et al.
J Neurol Neurosurg Psychiatry. 2023 Jan;94(1):42-48. doi: 10.1136/jnnp-2022-329485. Epub 2022 Oct 7.
【2023.4.17】
テーマ：アナフィラキシー〔担当 島田忠長〕
Adult anaphylaxis: A state-of-the-art review.
Carlo Maria Rossi, et al.
Eur J Intern Med. 2022 Jun;100:5-12. doi: 10.1016/j.ejim.2022.03.003. Epub 2022 Mar 6.
Kounis syndrome: A review article on epidemiology, diagnostic findings, management and complications of allergic acute coronary syndrome.
Mahmoud Abdelghany, et al.
Int J Cardiol. 2017 Apr 1;232:1-4. doi: 10.1016/j.ijcard.2017.01.124. Epub 2017 Jan 27.
Intravenous lipid emulsion for the treatment of drug toxicity.
Mehmet S Ozcan, et al.
J Intensive Care Med. 2014 Mar-Apr;29(2):59-70. doi: 10.1177/0885066612445978. Epub 2012 Jun 24.
テーマ：重症小児COVID-19患者の推移〔担当 石田茂誠〕
Severe COVID-19 outcomes in pediatrics: An observational cohort analysis comparing Alpha, Delta, and Omicron variants.
Amit Bahl, et al.
Lancet Reg Health Am. 2023 Feb;18:100405. doi: 10.1016/j.lana.2022.100405. Epub 2022 Dec 1.
【2023.4.10】
テーマ：重症市中肺炎に対するステロイド投与〔担当 大網毅彦〕
Hydrocortisone in Severe Community-Acquired Pneumonia.
Pierre-François Dequin, et al.
N Engl J Med. 2023 Mar 21. doi: 10.1056/NEJMoa2215145. Online ahead of print.
Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials.
Naveed Saleem, et al.
Chest. 2023 Mar;163(3):484-497. doi: 10.1016/j.chest.2022.08.2229. Epub 2022 Sep 7.
テーマ：不安定胸壁損傷〔担当 山本晃之〕
Operative vs Nonoperative Treatment of Acute Unstable Chest Wall Injuries: A Randomized Clinical Trial.
Niloofar Dehghan, et al.
JAMA Surg. 2022 Nov 1;157(11):983-990. doi: 10.1001/jamasurg.2022.4299.
【2023.3.20】
テーマ：ICUせん妄に対するハロペリドール〔担当者 富田啓介〕
Haloperidol for the Treatment of Delirium in ICU Patients.
N.C. Andersen-Ranberg, et al.
N Engl J Med. 2022 Dec 29;387(26):2425-2435. doi: 10.1056/NEJMoa2211868. Epub 2022 Oct 26.
テーマ：抜管後のNIV〔担当 ケイランディシュ フォアド〕
Effect of postextubation noninvasive ventilation with active humidification vs high-flow nasal cannula on reintubation in patients at very high risk for extubation failure: a randomized trial.
Gonzalo Hernández, et al.
Intensive Care Med. 2022 Dec;48(12):1751-1759. doi: 10.1007/s00134-022-06919-3. Epub 2022 Nov 18.
【2023.3.13】
テーマ：OHCA患者の血圧管理〔担当 菅なつみ〕
The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database.
Peter J McGuigan, et al.
Crit Care. 2023 Jan 5;27(1):4. doi: 10.1186/s13054-022-04289-2.
テーマ：ECPR〔担当者 前田健二朗〕
Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest.
Martje M Suverein, et al.
N Engl J Med. 2023 Jan 26;388(4):299-309. doi: 10.1056/NEJMoa2204511.
【2023.3.6】
テーマ：抜管前のSBTの方法〔担当 柄澤智史〕
Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece.
Arnaud W Thille, et al.
N Engl J Med. 2022 Nov 17;387(20):1843-1854. doi: 10.1056/NEJMoa2209041. Epub 2022 Oct 26.
テーマ：抜管後の酸素投与〔担当 飯澤勇太〕
High-Flow Versus VenturiMask Oxygen Therapy to Prevent Reintubation in Hypoxemic Patients after Extubation: A Multicenter Randomized Clinical Trial.
Salvatore Maurizio Maggiore, et al.
Am J Respir Crit Care Med. 2022 Dec 15;206(12):1452-1462. doi: 10.1164/rccm.202201-0065OC.
【2023.2.27】
テーマ：Contrast media and AKI〔担当 齋藤大輝〕
Renal outcomes following intravenous contrast administration in patients with acute kidney injury: a multi-site retrospective propensity-adjusted analysis.
Michael R Ehmann, et al.
Intensive Care Med. 2023 Feb;49(2):205-215. doi: 10.1007/s00134-022-06966-w. Epub 2023 Jan 30.
テーマ：院外心停止〔担当 廣瀬公仁〕
Association between inflammatory markers and survival in comatose, resuscitated out-of-hospital cardiac arrest patients.
Anne Toftgaard Pedersen, et al.
Scand Cardiovasc J. 2022 Dec;56(1):85-90. doi: 10.1080/14017431.2022.2074093.
【2023.2.20】
テーマ：周術期の血行動態〔担当者 今枝太郎〕
Perioperative changes in fluid distribution and haemodynamics in acute high-risk abdominal surgery.
Mirjana Cihoric, et al.
Crit Care. 2023 Jan 16;27(1):20. doi: 10.1186/s13054-023-04309-9.
テーマ：敗血症患者における加齢と免疫反応の関連について〔担当 篠崎勇志〕
Association between age and the host response in critically ill patients with sepsis.
Erik H A Michels, et al.
Crit Care. 2022 Dec 13;26(1):385. doi: 10.1186/s13054-022-04266-9.
【2023.2.13】
テーマ：タンパク栄養〔担当者 大島拓〕
The effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial.
Daren K Heyland, et al.
Lancet. 2023 Jan 25;S0140-6736(22)02469-2. doi: 10.1016/S0140-6736(22)02469-2. Online ahead of print.
Medical nutrition therapy and clinical outcomes in critically ill adults: a European multinational, prospective observational cohort study (EuroPN).
Martin Matejovic, et al.
Crit Care. 2022 May 18;26(1):143. doi: 10.1186/s13054-022-03997-z.
テーマ：酸素療法〔担当者 宮内清司
〕
Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia.
Elena Crescioli, et al.
Intensive Care Med. 2022 Jun;48(6):714-722. doi: 10.1007/s00134-022-06695-0. Epub 2022 Apr 20.
【2023.2.6】
テーマ：敗血症〔担当者 中田孝明〕
Using heparan sulfate octadecasaccharide (18-mer) as a multi-target agent to protect against sepsis.
Yi-En Liao, et al.
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209528120. doi: 10.1073/pnas.2209528120. Epub 2023 Jan 17.
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network; Nathan I Shapiro, et al.
N Engl J Med. 2023 Jan 21. doi: 10.1056/NEJMoa2212663. Online ahead of print.
Association Between Implementation of the Severe Sepsis and Septic Shock Early Management Bundle Performance Measure and Outcomes in Patients With Suspected Sepsis in US Hospitals
Chanu Rhee, et al.
JAMA Netw Open. 2021 Dec 1;4(12):e2138596. doi: 10.1001/jamanetworkopen.2021.38596.
The Importance of Shifting Sepsis Quality Measures From Processes to Outcomes
Michael Klompas, et al.
JAMA. 2023 Jan 20. doi: 10.1001/jama.2023.0340. Online ahead of print.
The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?
Rui Moreno, et al.
Crit Care. 2023 Jan 13;27(1):15. doi: 10.1186/s13054-022-04290-9.
テーマ：REBOA vs 蘇生的開胸術〔担当者 山本晃之〕
Zone 1 Endovascular Balloon Occlusion of the Aorta vs Resuscitative Thoracotomy for Patient Resuscitation After Severe Hemorrhagic Shock
Alexis L Cralley, et al.
JAMA Surg. 2022 Dec 21.doi: 10.1001/jamasurg.2022.6393. Online ahead of print.
【2023.1.30】
テーマ：ECPELLAのメタ解析〔担当者 服部憲幸〕
Comparison of ECMO vs ECpella in Patients With Non-Post-Pericardiotomy Cardiogenic Shock: An Updated Meta-Analysis.
Mario Iannaccone et al.
Cardiovasc Revasc Med. 2022 Jul;40:134-141. doi: 10.1016/j.carrev.2021.10.001. Epub 2021 Oct 5.
Meta-Analysis Comparing Venoarterial Extracorporeal Membrane Oxygenation With or Without Impella in Patients With Cardiogenic Shock.
Kirtipal Bhatia et al.
Am J Cardiol. 2022 Oct 15;181:94-101. doi: 10.1016/j.amjcard.2022.06.059. Epub 2022 Aug 21.
Impact of extracorporeal CPR with transcatheter heart pump support (ECPELLA) on improvement of short-term survival and neurological outcome in patients with refractory cardiac arrest - A single-site retrospective cohort study.
Takashi Unoki et al.
Resusc Plus. 2022 May 20;10:100244. doi: 10.1016/j.resplu.2022.100244. eCollection 2022 Jun.
テーマ：血栓予防におけるアスピリンと低分子ヘパリン〔担当者 飛世知宏〕
Aspirin or Low-Molecular-Weight Heparin for Thromboprophylaxis after a Fracture.
Major Extremity Trauma Research Consortium (METRC); Robert V O'Toole et al.
N Engl J Med. 2023 Jan 19;388(3):203-213. doi: 10.1056/NEJMoa2205973.
【2023.1.23】
テーマ：抗菌薬〔担当 東晶子〕
Antibiotic combinations reduce Staphylococcus aureus clearance.
Viktória Lázár, et al.
Nature. 2022 Oct;610(7932):540-546. doi: 10.1038/s41586-022-05260-5. Epub 2022 Oct 5.
テーマ：バソプレシン〔担当 池上さや〕
Association of Catecholamine Dose, Lactate, and Shock Duration at Vasopressin Initiation With Mortality in Patients With Septic Shock.
Gretchen L Sacha, et al.
Crit Care Med. 2022 Apr 1;50(4):614-623. doi: 10.1097/CCM.0000000000005317.
【2023.1.16】
テーマ：TAZ/CTLZ for HABP/VABP〔担当 齋藤大輝〕
Outcomes in participants with failure of initial antibacterial therapy for hospital-acquired/ventilator-associated bacterial pneumonia prior to enrollment in the randomized, controlled phase 3 ASPECT-NP trial of ceftolozane/tazobactam versus meropenem.
Marin H Kollef, et al.
Crit Care. 2022 Dec 1;26(1):373. doi: 10.1186/s13054-022-04192-w.
テーマ：心疾患を有する小児患者におけるCPR中のカルシウム投与〔担当 石田茂誠〕
Calcium Administration During Cardiopulmonary Resuscitation for In-Hospital Cardiac Arrest in Children With Heart Disease Is Associated With Worse Survival-A Report From the American Heart Association's Get With The Guidelines-Resuscitation (GWTG-R) Registry.
Gurpreet S Dhillon, et al.
Pediatr Crit Care Med. 2022 Nov 1;23(11):860-871. doi: 10.1097/PCC.0000000000003040. Epub 2022 Jul 27.
