千葉大学大学院医学研究院

アレルギー・臨床免疫学

千葉大学病院

アレルギー・膠原病内科

2020年

2019年

Saku A, Suehiro KI, Nakamura K, Nishimura N, Yokota M, Hirose K, Nakajima H. Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways.  Allergy. 2020;75(5):1253-1256.

Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM. Cryptic activation of an Irf8 enhancer governs cDC1 fate specification. Nat Immunol. 2019;20:1161-1173.

Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM. An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development. Nat Immunol. 2019;20:1174-1185.

Kono K, Hirose K, Makita S, Kageyama T, Tamachi T, Saku A, Suto A, Suzuki K, Nakajima H. IL-21 enhances mast cell accumulation in the intestine and exacerbates the development of experimental food allergy. Clin Exp Allergy. 2019;49:1523-1526.

Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates HDM-induced airway inflammation. J Allergy Clin Immunol. 2019;144(3):698-709.

Kubota A, Suto A, Suzuki K, Kobayashi Y, Nakajima H. Matrix metalloproteinase-12 produced by Ly6C(low) macrophages prolongs the survival after myocardial infarction by preventing neutrophil influx. J Mol Cell Cardiol. 2019;131:41-52

Kageyama T, Furuta S, Ikeda K, Kagami S, Kashiwakuma D, Sugiyama T, Umibe T, Watanabe N, Yamagata M, Nakajima H, Prognostic factors of Pneumocystis pneumonia in patients with systemic autoimmune diseases, PLoS One, 14(3), e0214324, 2019.

Eldredge LC, Creasy S, Tanaka S, Lai JF, Ziegler SF. Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ. J Immunol. 2019;202(9):2772-2781.

Theisen DJ, Ferris ST, Briseño CG, Kretzer N, Iwata A, Murphy KM, Murphy TL, Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation, Cancer Immunol Res. 2019;7(1):29-39

2018年

Tanaka S, Suto A, Iwamoto T, Kageyama T, Tamachi T, Takatori H, Suzuki K, Hirose K, Ohara O, Lefebvre V, Nakajima H. Sox12 promotes T reg differentiation in the periphery during colitis. J Exp Med. 2018;215(10):2509-2519.

Makita S, Takatori H, Tamachi T, Suto A, Suzuki K, Nakajima H. Analyses of dermal innate lymphoid cells in mice lacking T-bet and STAT6. Allergol Int. 2018;67S:S51-S53.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group. Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis. Eur Respir J. 2018;3;51(5):1702173.

Saku A, Furuta S, Hiraguri M, Ikeda K, Kobayashi Y, Kagami S, Kurasawa K, Matsumura R, Nakagomi D, Sugiyama T, Umibe T, Watanabe N, Nakajima H. Long-term outcomes of 188 Japanese patients with eosinophilic granulomatosis with polyangiitis. J Rheumatol. 2018;45(8):1159-1166.

Nawata K, Nakamura J, Ikeda K, Furuta S, Nakajima H, Ohtori S, Hagiwara S, Wako Y, Miura M, Kawarai Y, Sugano M, Yoshino K, Orita S, Inage K, Akazawa T. Transitional changes in the incidence of osteonecrosis in systemic lupus erythematosus patients: focus on immunosuppressant agents and glucocorticoids. Rheumatology (Oxford). 2018;57(5):844-849

Mitamura Y, Nunomura S, Nanri Y, Arima K, Yoshihara T, Komiya K, Fukuda S, Takatori H, Nakajima H, Furue M, Izuhara K. Hierarchical control of IL-13 signals in lung fibroblasts by STAT6 and SOX11. J Biol Chem. 2018;293(38):14646-14658

Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM, Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med. 2018;215(5):1417-1435.

Sato S, Masui K, Nishina N, Kawaguchi Y, Kawakami A, Tamura M, Ikeda K, Nunokawa T, Tanino Y, Asakawa K, Kaneko Y, Gono T, Ukichi T, Kaieda S, Naniwa T, Kuwana M, investigators J. Initial predictors of poor survival in myositis-associated interstitial lung disease: a multicentre cohort of 497 patients. Rheumatology (Oxford). 2018;57(7):1212-1221.

Tanaka S, Pfleger C, Lai JF, Roan F, Sun SC, Ziegler SF. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018;23(3):796-807.

Takahashi K, Meguro K, Kawashima H, Kashiwakuma D, Kagami S, Ohta S, Ono J, Izuhara K Iwamoto I. Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics. Journal of Asthma 2018;12:1-8

Ishida M, Kuroiwa Y, Yoshida E, Sato M, Krupa D, Henry N, Ikeda K, Kaneko Y. Residual symptoms and disease burden among patients with rheumatoid arthritis in remission or low disease activity: a systematic literature review. Mod Rheumatol. 2018:11:1-11.

Iwamoto T, Dorschner J, Jolly M, Huang X, Niewold TB. Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds.Lupus Sci Med. 2018;5(1):e000246

2017年

Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H. Dectin-1 plays an important role in house dust mite-induced allergic airway inflammation through the activation of CD11b+ dendritic cells. J Immunol. 2017;198(1):61-70.

Ito T, Hirose K, Norimoto A, Saku A, Nakajima H. Dectin-1 plays a critical role in HDM-induced PGE2 production in macrophages. Allergol Int. 2017;66S:S44-S46.

Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3g and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017;214(10):3037-3050.

Kageyama T, Suto A, Iwamoto T, Tanaka S, Suehiro K, Yokoyama Y, Saku A, Furuta S, Ikeda K, Suzuki K, Hirose K, Nakajima H. IL-21 exacerbates autoimmune myositis by enhancing the accumulation of GM-CSF-producing gd T cells in the muscle. Immuno Horizons 2017;1(8):176-187.

Hirose K, Ito T, Nakajima H. "Roles of Dectin-1 in Allergic Airway Inflammation. Crit Rev Immunol. 2017;37(1):15-21."

Furuta S, Sugiyama T, Umibe T, Kaneko Y, Amano K, Kurasawa K, Nakagomi D, Hiraguri M, Hanaoka H, Sato Y, Ikeda K, Nakajima H; LoVAS Trial study investigators. Low-dose glucocorticoids plus rituximab versus high-dose glucocorticoids plus rituximab for remission induction in ANCA-associated vasculitis (LoVAS): protocol for a multicentre, open-label, randomised controlled trial. BMJ Open. 2017 Dec 14;7(12):e018748.

Matsuki A, Takatori H, Makita S, Yokota M, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H. T-bet inhibits innate lymphoid cell-mediated eosinophilic airway inflammation by suppressing IL-9 production. J Allergy Clin Immunol. 2017 Apr;139(4):1355-1367

Hirose K, Iwata A, Tamachi T, Nakajima H. Allergic airway inflammation: key players beyond the Th2 cell pathway. Immunol Rev. 2017 Jul;278(1):145-161.

Hosokawa J, Suzuki K, Meguro K, Tanaka S, Maezawa Y, Suto A, Fujimura L, Sakamoto A, Clevers H, Ohara O, Nakajima H. IκBNS enhances T follicular helper cell differentiation and function as downstream of Ascl2. J Allergy Clin Immunol. 2017 Jul;140(1):288-291.e8

Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K,Nakajima H. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy. 2017 Jul;72(7):1043-1053.

Iwata A, Durai V, Tussiwand R, Briseño CG, Wu X, Grajales-Reyes GE, Egawa T, Murphy TL, Murphy KM. Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex. Nat Immunol. 2017;18(5):563-572.

Furuta S, Chaudhry AN, Arimura Y, Dobashi H, Fujimoto S, Homma S, Rasmussen N, Jayne DR.
Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts. J Rheumatol. 2017;44(2):216-222.

Nakagomi D, Cousins C, Sznajd J, Furuta S, Mohammad AJ, Luqmani R, Jayne D.
Development of a score for assessment of radiologic damage in large-vessel vasculitis (Combined Arteritis Damage Score, CARDS). Clin Exp Rheumatol. 2017;35 Suppl 103(1):139-145.

Kawashima H, Kagami SI, Kashiwakuma D, Takahashi K, Yokota M, Furuta S, Iwamoto I.
Long-term use of biologic agents does not increase the risk of serious infections in elderly patients with rheumatoid arthritis. Rheumatol Int. 2017;37(3):369-376.

2016年

Wu X, Briseño CG, Grajales-Reyes GE, Haldar M, Iwata A, Kretzer NM, Kc W, Tussiwand R, Higashi Y, Murphy TL, Murphy KM. Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate. Proc Natl Acad Sci U S A. 2016;113(51):14775-14780.

Briseño CG, Haldar M, Kretzer NM, Wu X, Theisen DJ, Kc W, Durai V, Grajales-Reyes GE, Iwata A, Bagadia P, Murphy TL, Murphy KM. Distinct transcriptional programs control cross-priming in classical and monocyte-derived dendritic cells. Cell Rep. 2016;15(11):2462-74.

Kobayashi Y, Ikeda K, Nakamura T, Yamagata M, Nakazawa T, Tanaka S, Furuta S, Umibe T, Nakajima H. Severity and Diurnal Improvement of Morning Stiffness Independently Associate with Tenosynovitis in Patients with Rheumatoid Arthritis. PLoS One. 2016;11(11):e0166616.

Yamagata M, Ikeda K, Tsushima K, Iesato K, Abe M, Ito T, Kashiwakuma D, Kagami S, Iwamoto I, Nakagomi D, Sugiyama T, Maruyama Y, Furuta S, Jayne D, Uno T, Tatsumi K, Nakajima H.
Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital-Based Japanese Patients. Arthritis Rheumatol. 2016;68(3):713-23.

Ikeda K, Narita A, Ogasawara M, Ohno S, Kawahito Y, Kawakami A, Ito H, Matsushita I, Suzuki T, Misaki K, Ogura T, Kamishima T, Seto Y, Nakahara R, Kaneko A, Nakamura T, Henmi M, Fukae J, Nishida K, Sumida T, Koike T. Consensus-based identification of factors related to false-positives in ultrasound scanning of synovitis and tenosynovitis. Mod Rheumatol. 2016;26(1):9-14.

Meguro K, Nakagomi D, Suzuki K, Hosokawa J, Fukuta T, Yokota M, Maezawa Y, Suto A, Nakajima H. SOCS3 expressed in M2 macrophages attenuates contact hypersensitivity by suppressing MMP12 production. J Invest Dermatol. 2016;136(3):649-57.

Meguro K, Suzuki K, Nakajima H. Reply to Letter to the Editor. Arthritis Rheumatol. 2016;68(3):771-2.

2015年

Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL, Murphy KM. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nat Immunol. 2015;16(7):708-17.

Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM. Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. 2015;42(5):916-28.

Nakagomi D, Suzuki K, Meguro K, Hosokawa J, Tamachi T, Takatori H, Suto A, Matsue H, Ohara O, Nakayama T, Shimada S, Nakajima H. Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity. J Allergy Clin Immunol. 2015;135(5):1397-400.

Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami S, Hirose K, Kubo M, Hori S, Nakajima H. Helios enhances Treg cell function in cooperation with Foxp3. Arthritis Rheumatol. 2015;67(6):1491-502.

Yokoyama Y, Furuta S, Ikeda K, Hirose K, Nakajima H. Corticosteroid-sparing effect of tacrolimus in the initial treatment of dermatomyositis and polymyositis. Mod Rheumatol. 2015;25(6):888-92.

Meguro K, Suzuki K, Hosokawa J, Sanayama Y, Tanaka S, Furuta S, Ikeda K, Takatori H, Suto A, Sakamoto A, Ohara O, Nakajima H. Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis. Arthritis Rheumatol. 2015;67(10):2651-60.

Jones RB, Furuta S (SF is a shared first author), Tervaert JW, Hauser T, Luqmani R, Morgan MD, Peh CA, Savage CO, Segelmark M, Tesar V, van Paassen P, Walsh M, Westman K, Jayne DR; European Vasculitis Society (EUVAS). Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis: 2-year results of a randomised trial. Ann Rheum Dis. 2015;74(6):1178-82.

Furuta S, Cousins C, Chaudhry A, Jayne D. Clinical features and radiological findings in large vessel vasculitis: are Takayasu arteritis and giant cell arteritis 2 different diseases or a single entity? J Rheumatol. 2015;42(2):300-8.

Hiraga M, Ikeda K, Shigeta K, Sato A, Yoshitama T, Hara R, Tanaka Y. Sonographic measurements of lowechoic synovial area in the dorsal aspect of metatarsophalangeal joints in healthy subjects. Mod Rheumatol 2015;25(3):386-92.

2014年

Sashida G, Harada H, Matsui H, Oshima M, Yui M, Harada Y, Tanaka S,　Mochizuki-Kashio M, Wang C, Saraya A, Muto T, Hayashi Y, Suzuki K, Nakajima H,　Inaba T, Koseki H, Huang G, Kitamura T, Iwama A. Ezh2 loss promotes development　of myelodysplastic syndrome but attenuates its predisposition to leukaemic　transformation. Nat Commun. 2014;5:4177.

Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H. Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR・t induction as downstream targets of Stat3. J Exp Med. 2014;211(9):1857-74.

Ikeda K, Kambe N, Takei S, Nakano T, Inoue Y, Tomiita M, Oyake N, Satoh T, Yamatou T, Kubota T, Okafuji I, Kanazawa N, Nishikomori R, Shimojo N, Matsue H, Nakajima H. Ultrasonographic assessment reveals detailed distribution of synovial inflammation in Blau syndrome. Arthritis Res Ther. 2014;16(2):R89.

Norimoto A, Hirose K, Iwata A, Tamachi T, Yokota M, Takahashi K, Saijo S,　Iwakura Y, Nakajima H. Dectin-2 promotes house dust mite-induced T helper type 2 and type 17 cell differentiation and allergic airway inflammation in mice. Am J Respir Cell Mol Biol. 2014;51(2):201-9.

Iwamoto T, Suto A, Tanaka S, Takatori H, Suzuki K, Iwamoto I, Nakajima H.　Interleukin-21-Producing c-Maf-expressing CD4+ T cells induce effector CD8+ T　cells and enhance autoimmune inflammation in scurfy mice. Arthritis Rheumatol. 2014;66(8):2079-90.

Iwamoto T, Ikeda K, Hosokawa J, Yamagata M, Tanaka S, Norimoto A, Sanayama Y, Nakagomi D, Takahashi K, Hirose K, Sugiyama T, Sueishi M, Nakajima H. Ultrasonographic assessment predicts relapse after discontinuation of biological agents in patients with rheumatoid arthritis in clinical remission. Arthritis Care Res (Hoboken). 2014;66:1576-81.

Sanayama Y, Ikeda K, Saito Y, Kagami S, Yamagata M, Furuta S, Kashiwakuma D, Iwamoto I, Umibe T, Nawata Y, Matsumura R, Sugiyama T, Sueishi M, Hiraguri M, Nonaka K, Ohara O, Nakajima H. Prediction of therapeutic responses to tocilizumab in patients with rheumatoid arthritis - biomarkers identified by analyses of gene expression in peripheral blood mononuclear cells using genome-wide DNA microarray. Arthritis Rheumatol. 2014;66(6):1421-31.

Ikeda K, Seto Y, Narita A, Kawakami A, Kawahito Y, Ito H, Matsushita I, Ohno S, Nishida K, Suzuki T, Kaneko A, Ogasawara M, Fukae J, Henmi M, Sumida T, Kamishima T, Koike T. Ultrasound assessment of synovial pathologic features in rheumatoid arthritis using comprehensive multi-plane images of the 2nd metacarpophalangeal joint - Identification of the components which are reliable and influential on the global assessment of the whole joint. Arthritis Rheumatol. 2014;66(3):523-32.

Furuta S, Chaudhry AN, Hamano Y, Fujimoto S, Nagafuchi H, Makino H, Matsuo S, Ozaki S, Endo T, Muso E, Ito C, Kusano E, Yamagata M, Ikeda K, Kashiwakuma D, Iwamoto I, Westman K, Jayne D. Comparison of Phenotype and Outcome in Microscopic Polyangiitis Between Europe and Japan. J Rheumatol. 2014;41(2):325-33.

Yokota M, Suzuki K, Tokoyoda K, Meguro K, Hosokawa J, Tanaka S, Ikeda K, Mikata T, Nakayama T, Kohsaka H, Nakajima H. Roles of mast cells in the pathogenesis of inflammatory myopathy. Arthritis Res Ther. 2014;16(2):R72.

Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H. Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol. 2014;26(2):103-14.

Ikeda K, Seto Y, Ohno S, Sakamoto F, Henmi M, Fukae J, Narita A, Nakagomi D, Nakajima H, Tanimura K, Koike T. Analysis of the factors which influence the measurement of synovial power Doppler signals with semi-quantitative and quantitative measures - a pilot multicenter exercise in Japan. Mod Rheumatol. 2014;24(3):419-25.

Saito Y, Kagami S, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H. AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor γt-induced Th17 cell differentiation. Arthritis Rheumatol. 2014;66(5):1185-94.

2013年

Ikeda K, Nakagomi D, Sanayama Y, Yamagata M, Okubo A, Iwamoto T, Kawashima H, Takahashi T, Nakajima H. Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents. J Rheumatol. 2013;40(12):1967-76.

Bakewell C, Olivieri I, Aydin S, Dejaco C, Ikeda K, Gutierrez M, Terslev L, Thiele R, D'Agostino M, Kaeley G. Ultrasound and MRI in the evaluation of psoriatic dactylitis: status and perspectives. J Rheumatol. 2013;40(12):1951-7.

Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One. 2013;8(2):e56381.

Iwata A, Ikeda K, Hirose K, Takatori H, Takahashi K, Suzuki Y, Tanaka S, Suto A, Nakajima H. Pre-dinner administration increases the efficacy of proton pump inhibitors on refractory GERD symptoms in connective tissue disease patients. Mod Rheumatol. 2013;23(2):357-64.

Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori T, Suzuki K, Takabayashi K, Nakajima H. Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment. Arthritis Rheum. 2013;65(4):890-8.

Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H. Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity. J Invest Dermatol. 2013;133(3):702-11.

Kobayashi Y, Iwata A, Suzuki K, Suto A, Kawashima S, Saito Y, Owada T, Kobayashi M, Watanabe N, Nakajima H. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells. Proc Natl Acad Sci U S A. 2013;110(13):5121-6.

Hosokawa J, Suzuki K, Nakagomi D, Tamachi T, Takatori H, Suto A, Nakajima H. Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells. Int Arch Allergy Immunol. 2013;161 Suppl 2:37-43.

Kawashima S, Hirose K, Takahashi K, Tamachi T, Ikeda K, Tokoyoda K, Nakayama T, Nakajima H. Interleukin-25 induces pulmonary arterial remodeling via natural killer T cell-dependent mechanisms. Int Arch Allergy Immunol. 2013;161 Suppl 2:118-24.

Tanaka S, Ikeda K, Uchiyama K, Iwamoto T, Sanayama Y, Okubo A, Nakagomi D, Takahashi K, Yokota M, Suto A, Suzuki K, Nakajima H. [18F] FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis. Rheumatology (Oxford) 2013;52(7):1271-8.

Watanabe K, Sakai R, Koike R, Sakai F, Sugiyama H, Tanaka M, Komano Y, Akiyama Y, Mimura T, Kaneko M, Tokuda H, Iso T, Motegi M, Ikeda K, Nakajima H, Taki H, Kubota T, Kodama H, Sugii S, Kuroiwa T, Nawata Y, Shiozawa K, Ogata A, Sawada S, Matsukawa Y, Okazaki T, Mukai M, Iwahashi M, Saito K, Tanaka Y, Nanki T, Miyasaka N, Harigai M. Clinical characteristics and risk factors for Pneumocystis jirovecii pneumonia in patients with rheumatoid arthritis receiving adalimumab: a retrospective review and case-control study of 17 patients. Mod Rheumatol. 2013;23(6):1085-93.

Tanaka S, Suto A, Ikeda K, Sanayama Y, Nakagomi D, Iwamoto T, Suzuki K, Kambe N, Matsue H, Matsumura R, Kashiwakuma D, Iwamoto I, Nakajima H. Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor b. Rheumatology (Oxford) 2013;52(11):1963-72.

Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H. Tumor suppresser p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 2013;191(7):3614-23.

Ikeda K, Nakagomi D, Sanayama Y, Yamagata M, Okubo A, Iwamoto T, Kawashima H, Takahashi K, Nakajima H. Correlation of radiographic progression with the cumulative activity of synovitis estimated by power Doppler ultrasound in rheumatoid arthritis: difference between patients treated with methotrexate and those treated with biological agents. J Rheumatol. 2013;40(12):1967-76.

2012年

Furuta S, Chow YW, Chaudhry AN, Jayne D. Switching of anti-TNF-α agents in Behcet's disease. Clin Exp Rheumatol. 2012;30(3 Suppl 72):S62-8.

Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Annexin A10 in human oral cancer: biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways. PLoS One. 2012;7(9):e45510.

Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Bukawa H. Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest. BMC Cancer. 2012;12:321.

Saito Y, Kagami S-I, Kawashima S, Takahashi K, Ikeda K, Hirose K, Oshitari T, Yamamoto S, Okamoto Y, Nakajima H. Roles of CRTH2+ CD4+ T Cells in Immunoglobulin G4-Related Lacrimal Gland Enlargement. Int Arch Allergy Immunol. 2012;158 Suppl 1:42-6.

Yoh K, Morito N, Ojima M, Shibuya K, Yamashita Y, Morishima Y, Ishii Y, Kusakabe M, Nishikii H, Fujita A, Matsunaga E, Okamura M, Hamada M, Suto A, Nakajima H, Shibuya A, Yamagata K, Takahashi S. Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice. Eur J Immunol. 2012;42(8):1999-2009.

Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M. Subtilase cytotoxin suppresses nitric oxide production by macrophages through inhibition of NF-κB activation. Infec Immun. 2012 Nov;80(11):3939-51.

Kawashima S, Hirose K, Iwata A, Takahashi T, Ohkubo A, Tamachi T, Ikeda K Kagami S, Nakajima H. β-glucan curdlan induces IL-10-producing CD4+ T cells and inhibits allergic airway inflammation. J Immunol. 2012;189(12):5713-21.

2011年

Oya Y, Watanabe N, Owada T, Oki M, Ikeda K, Suto A, Kagami S-I, Hirose K, Kishimoto T, Nakajima H. Lack of B and T lymphocyte attenuator exacerbates autoimmune disorders and induces Fas-independent liver injury in MRL-lpr/lpr mice. Int Immunol. 2011;23(5):335-44.

Oki M, Watanabe N, Owada T, Oya Y, Ikeda K, Saito Y, Matsumura R, Seto Y, Iwamoto I, Nakajima H. A functional polymorphism in B and T lymphocyte attenuator is associated with susceptibility to rheumatoid arthritis. Clin Dev Immunol. 2011;2011:305656.

Iida K, Suzuki K, Yokota M, Nakagomi D, Wakashin H, Iwata A, Kawashima H, Takatori H, Nakajima H. STAT4 is required for IFN-β-induced MCP-1 mRNA expression in murine mast cells. Int Arch Allergy Immunol. 2011;155(suppl1):71-76.

Takahashi K, Hirose K, Kawashima S, Niwa Y, Wakashin H, Iwata A, Tokoyoda K, Renauld JC, Iwamoto I, Nakayama T, Nakajima H. IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation. J Allergy Clin Immunol. 2011;128(5):1067-76.e1-6.

Suzuki K, Murphy SH, Xia Y, Yokota M, Nakagomi D, Liu F, Verma IM, Nakajima H. Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS One. 2011;6(9):e25412.

Hiwasa T, Utsumi T, Yasuraoka M, Hanamura N, Shimada H, Nakajima H, Kitagawa M, Iwadate Y, Goto K, Takeda A, Ohtsuka K, Ariga H, Takiguchi M. Functional similarity of anticancer drugs by MTT bioassay. J Cancer Sci Ther. 2011;3:250-255.

2010年

Horikoshi M, Suzuki T, Sugihara M, Kondo Y, Tsuboi H, Uehara T, Hama M, Takase K, Ohno S, Ishigatsubo Y, Yoshida Y, Sagawa A, Ikeda K, Ota T, Matsumoto I, Ito S, Sumida T. Comparison of low-field dedicated extremity magnetic resonance imaging with articular ultrasonography in patients with rheumatoid arthritis. Mod Rheumatol 2010;20(6):556-60.

Iwata A, Watanabe N, Oya Y, Owada T, Ikeda K, Suto A, Kagami S, Hirose K, Kanari H, Kawashima S, Nakayama T, Taniguchi M, Iwamoto I, Nakajima H. Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis. J Immunol. 2010;184(1):127-33.

Hasegawa A, Hayashi K, Kishimoto H, Yang M, Tofukuji S, Suzuki K, Nakajima H, Hoffman RM, Shirai M, Nakayama T. Color-coded real-time cellular imaging of T lymphocyte accumulation and focus formation in mouse asthma model. J Allergy Clin Immunol. 2010;125(2):461-468.e6.

Owada T, Watanabe N, Oki M, Oya Y, Saito Y, Saito T, Iwamoto I, Murphy TL, Murphy KM, Nakajima H. Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells. J Leukoc Biol. 2010;87(3):425-32.

Hiramatsu Y, Suto A, Kashiwakuma D, Kanari H, Kagami S, Ikeda K, Hirose K, Watanabe N, Grusby MJ, Iwamoto I, Nakajima H. c-Maf activates the promoter and enhancer of IL-21 gene while TGF-β inhibits c-Maf-induced IL-21 expression in CD4+ T cells. J Leukoc Biol. 2010;87(4):703-12.

Kanari H, Kagami S, Kashiwakuma D, Oya Y, Furuta S, Ikeda K, Suto A, Suzuki K, Hirose K, Watanabe N, Okamoto Y, Yamamoto S, Iwamoto I, Nakajima H. Role of Th2 cells in IgG4-related lacrimal gland enlargement. Int Arch Allergy Immunol. 2010;152 Suppl 1:47-53.

Kashiwakuma D, Suto A, Hiramatsu Y, Ikeda K, Takatori H, Suzuki K, Kagami S, Hirose K, Watanabe N, Iwamoto I, Nakajima H. B and T lymphocyte attenuator suppresses IL-21 production from follicular helper T cells and subsequent humoral immune responses. J Immunol. 2010;185(5):2730-6.

Kamada N, Yoneyama K, Togawa Y, Suehiro K, Shinkai H, Yokota M, Matsuda K, Oda S, Hirasawa H, Matsue H. Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies. J Dermatol. 2010;37(6):534-6.

Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. 2010;32(6):840-51.

2009年

Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH. Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Sci Signal. 2009;2(57):ra5.

Kagami S, Owada T, Kanari H, Saito Y, Suto A, Ikeda K, Hirose K, Watanabe N, Iwamoto I, Nakajima H. Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. 2009;21(6):679-89.

Tamachi T, Takatori H, Fujiwara M, Hirose K, Maezawa Y, Kagami S, Suto A, Watanabe N, Iwamoto I, Nakajima H. STAT6 Inhibits T-bet-independent Th1 cell differentiation. Biochem Biophys Res Commun. 2009;382(4):751-5.

Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206(1):35-41.

Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, Maezawa Y, Drucker DJ, Engleman E, Winer D, Dosch HM. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15(8):921-9.

Sutherland AP, Van Belle T, Wurster AL, Suto A, Michaud M, Zhang D, Grusby MJ, von Herrath M. Interleukin-21 is required for the development of type 1 diabetes in NOD mice. Diabetes. 2009;58(5):1144-55.

2008年

Dass S, Bowman SJ, Vital EM, Ikeda K, Pease CT, Hamburger J, Richards A, Rauz S, Emery P. Reduction of fatigue in Sjogren syndrome with rituximab: results of a randomised, double-blind, placebo-controlled pilot study. Ann Rheum Dis. 2008;67(11):1541-4.

Brown AK, Conaghan PG, Karim Z, Quinn MA, Ikeda K, Peterfy CG, Hensor E, Wakefield RJ, O'Connor PJ, Emery P. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis. Arthritis Rheum. 2008;58(10):2958-67.

Oya Y, Watanabe N, Owada T, Oki M, Hirose K, Suto A, Kagami S-i, Nakajima H, Kishimoto T, Iwamoto I, Murphy TL, Murphy KM, Saito Y. Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum. 2008;58(8):2498-510.

Kagami S-i, Kanari H, Suto A, Fujiwara M, Ikeda K, Hirose K, Watanabe N, Iwamoto I, Nakajima H. HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells. Int Arch Allergy Immunol. 2008;146 Suppl 1:61-6.

Furuta S, Kagami S-I, Tamachi T, Ikeda K, Fujiwara M. Suto A, Hirose K, Watanabe N, Saito Y, Iwamoto I, Nakajima H. Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation. J Immunol. 2008;180(10):6656-62.

Suto A, Kashiwakuma D, Kagami S-I, Hirose K, Watanabe N, Yokote K, Saito Y, Nakayama T, Grusby MJ, Iwamoto I, Nakajima H. Development and characterization of IL-21-producing CD4+ T cells. 2008;205(6):1369-79.

Hirose K, Wakashin H, Oki M, Kagami S-I, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H. GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem Biophys Res Commun. 2008;374(3):507-11.

Wakashin H, Hirose K, Maezawa Y, Kagami S-I, Suto A, Watanabe N, Saito Y, Hatano M, Tokuhisa T, Iwakura Y, Puccetti P, Iwamoto I, Nakajima H. IL-23 and Th17 cells enhance Th2 cell-mediated eosinophilic airway inflammation in mice. Am J Respir Crit Care Med. 2008;178(10):1023-32.

Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, Taniguchi M. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J Exp Med. 2008;205(12):2727-33.

Hirose K, Abramovich C, Argiropoulos B, Humphries RK. Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor. Oncogene. 2008;27(46):6056-67.

Suzuki K, Verma IM. Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell. 2008;134(3):485-95.

2007年

Fujiwara M, Hirose K, Kagami S-I, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H. T-bet inhibits both Th2 cell-mediated eosinophil recruitment and Th17 cell-mediated neutrophil recruitment into the airways. J Allergy Clin Immunol. 2007;119(3):662-70.

Tamachi T, Watanabe N, Oya Y, Kagami S-I, Hirose K, Saito Y, Iwamoto I, Nakajima H. B and T lymphocyte attenuator inhibits antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol. 2007;143 Suppl 1:50-5.

Tokumasa N, Suto A, Kagami S-i, Furuta S, Hirose K, Watanabe N, Saito Y, Shimoda K, Iwamoto I, Nakajima H. Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-γ production and the induction of Th1 cell differentiation. Blood. 2007;110(2):553-60.

2006年

Maezawa Y, Nakajima H, Suzuki K, Tamachi T, Ikeda K, Inoue J-I, Saito Y, Iwamoto I. Involvement of TNF receptor-associated factor 6 in IL-25 receptor signaling. J Immunol. 2006;176(2):1013-8.

Tamachi T, Maezawa Y, Ikeda K, Kagami S, Hatano M, Seto Y, Suto A, Suzuki K, Watanabe N, Saito Y, Tokuhisa T, Iwamoto I, Nakajima H. IL-25 enhances allergic airway inflammation by amplifying a Th2 cell-dependent pathway in mice. J Allergy Clin Immunol. 2006;118(3):606-14.

Barnstein BO, Li G, Wang Z, Kennedy S, Chalfant C, Nakajima H, Bunting KD, Ryan JJ. Stat5 expression is required for IgE-mediated mast cell function. J Immunol. 2006;177(5):3421-6.

Yagi J, Arimura Y, Takatori H, Nakajima H, Iwamoto I, Uchiyama T. Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells. Int Immunol. 2006;18(12):1681-90.

Suto A, Wurster AL, Reiner SL, Grusby MJ. IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol. 2006;177(6):3721-7.

2005年

Takatori H, Nakajima H, Hirose K, Kagami S-i, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I. Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J Immunol. 2005;174(6):3734-40..

Takatori H, Nakajima H, Kagami S-i, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I. Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of SOCS3 expression. J Immunol. 2005;174(7):4105-12.

Ikeda K, Nakajima H, Suzuki K, Watanabe N, Kagami S-i, Iwamoto I. Stat5a is essential for the proliferation and survival of murine mast cells. Int Arch Allergy Immunol. Int Arch Allergy Immunol. 2005;137 Suppl 1:45-50.

Suto A, Nakajima H, Tokumasa N, Takatori H, Kagami S, Suzuki K, Iwamoto I. Murine plasmacytoid dendritic cells produce IFN-γ upon IL-4 stimulation. J Immunol. 2005;175(9):5681-9.

2004年

Maezawa Y, Nakajima H, Seto Y, Suto A, Kumano K, Kubo S, Karasuyama H, Saito Y, Iwamoto I. IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways. Clin Exp Immunol. 2004;135(1):12-8.

Mori Y, Hirose K, Suzuki K, Nakajima H, Seto Y, Ikeda K, Shimoda K, Nakayama K, Saito Y, Iwamoto I. Tyk2 is essential for IFN-α-induced gene expression in mast cells. Int Arch Allergy Immunol. 2004;134 Suppl 1:25-9.

Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, Otsu K. Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription (STAT) 6-deficient mice. Circulation. 2004;110(17):2631-7.

2003年

Seto Y, Nakajima H, Suto A, Shimoda K, Saito Y, Nakayama KI, Iwamoto I. Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol. 2003;170(2):1077-83.

Ikeda K, Nakajima H, Suzuki K, Kagami S-i, Hirose K, Suto A, Saito Y, Iwamoto I. Mast cells produce Interleukin-25 upon FcεRI-mediated activation. Blood 2003;101(9):3594-6.

Suzuki K, Nakajima H, Ikeda K, Tamachi T, Hiwasa T, Saito Y, Iwamoto I. Stat6-protease but not Stat5-protease is inhibited by an elastase inhibitor, ONO-5046. Biochem Biophys Res Commun. 2003;309(4):768-73.

Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I. IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells. J Exp Med. 2003;198(11):1717-27.

Minoshima Y, Kawashima T, Hirose K, Tonozuka Y, Kawajiri A, Bao YC, Deng X, Tatsuka M, Narumiya S, May WS Jr, Nosaka T, Semba K, Inoue T, Satoh T, Inagaki M, Kitamura T. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell. Dev Cell. 2003;4(4):549-60.

Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. Nat Immunol. 2003;4(7):670-9.

Gavrieli M, Watanabe N, Loftin SK, Murphy TL, Murphy KM. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem Biophys Res Commun. 2003;312(4):1236-43.

2002年

Suto A, Nakajima H, Ikeda K, Kubo S, Nakayama T, Taniguchi M, Saito Y, Iwamoto I. CD4+ CD25+ T cell development is regulated by at least two distinct mechanisms. Blood. 2002;99(2):555-60.

Kunstle G, Laine J, Pierron G, Kagami S-i, Nakajima H, Hoh F, Roumestand C, Stern M-H, Noguchi M. Identification of Akt association and oligomerization domeins of the Akt kinase coactivator TCL1. Mol Cell Biol. 2002;22(5):1513-25.

Hoshimoto A, Suzuki Y, Katsuno T, Nakajima H, Saito Y. Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A. Br J Pharmacol. 2002;136(2):280-6.

Suzuki K, Nakajima H, Kagami S-i, Suto A, Ikeda K, Hirose K, Hiwasa T, Takeda K, Saito Y, Akira S, Iwamoto I. Proteolytic processing of Stat6 signaling in mast cells as a negative-regulatory mechanism. J Exp Med. 2002;196(1):27-38.

Suto A, Nakajima H, Hirose K, Suzuki K, Kagami S-i, Seto Y, Hoshimoto A, Saito Y, Foster DC, Iwamoto I. Interleukin-21 prevents antigen-induced IgE production by inhibiting germline Cε transcription of IL-4-stimulated B cells. Blood 2002;100(13):4565-73.

2001年

Suto A, Nakajima H, Kagami S-i, Suzuki K, Saito Y, Iwamoto I. Role of CD4+ CD25+ regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. Am J Respir Crit Care Med. 2001;164(4):680-7.

Kagami S-i, Nakajima H, Suto A, Hirose K, Suzuki K, Morita S, Kato I, Saito Y, Kitamura T, Iwamoto I. Stat5a regulates T helper cell differentiation by several distinct mechanisms. Blood. 2001;97(8):2358-65.

Goto D, Nakajima H, Mori Y, Kurasawa K, Kitamura N, Iwamoto I. Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-β/Smad3-mediated signaling. Biochem Biophys Res Commun. 2001;281(5):1100-5.

Horikawa K, Kaku H, Nakajima H, Davey HW, Henninghausen L, Iwamoto I, Yasue T, Kariyone A, Takatsu K. Essential role of Stat5 for IL-5-dependent IgH switch recombination in mouse B cells. J Immunol. 2001;167(9):5018-26.

Kasai M, Kurasawa K, Nakajima H, Iwamoto I. T cell vaccination eliminates antigen-specific T cells and prevents antigen-induced eosinophil recruitment into the tissue. Int Arch Allergy Immunol. 2001;125 Suppl 1:59-66.

Uchida Y, Kurasawa K, Nakajima H, Nakagawa N, Tanabe E, Sueishi M, Saito Y, Iwamoto I. Increase of dendritic cell type 2 by altered response to interleukin-4 in atopic patients. J Allergy Clin Immunol. 2001;108(6):1005-11.

Hirose K, Kawashima T, Iwamoto I, Nosaka T, Kitamura T. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J Biol Chem. 2001;276(8):5821-8.

Kitamura T, Kawashima T, Minoshima Y, Tonozuka Y, Hirose K, Nosaka T. Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation. Cell Struct Funct. 2001;26(6):645-51.

2000年

Nakajima H, Nakao A, Kumano K, Yamamoto H, Iwamoto I. Systemic T helper 2 cell activation is not sufficient for antigen-induced eosinophil recruitment into the airways. Int Arch Allergy Immunol. 2000;122 Suppl 1:20-4.

Suzuki K, Nakajima H, Saito Y, Saito T, Leonard WJ, Iwamoto I. Janus kinase 3 (Jak3) is essential for common cytokine receptor γ chain (γc)-dependent signaling: comparative analysis of γc, Jak3, and γc and Jak3 double deficient mice. Int Immunol. 2000;12(2):123-32.

Kagami S, Nakajima H, Kumano K, Suzuki K, Suto A, Imada K, Davey HW, Saito Y, Takatsu K, Leonard WJ, Iwamoto I. Both Stat5a and Stat5b are required for antigen-induced eosinophil and T cell recruitment into the tissue. Blood. 2000;95(4):1370-7.

Umibe T, Kita Y, Nakao A, Nakajima H, Fukuda T, Yoshida S, Sakamaki T, Saito Y, Iwamoto I. Clonal expansion of T cells infiltrating in the airways of non-atopic asthmatics. Clin Exp Immunol. 2000;119(3):390-7.

Oishi Y, Sakamoto A, Kurasawa K, Nakajima H, Nakao A, Nakagawa N, Tanabe E, Saito Y, Iwamoto I. CD4-CD8- T cells bearing invariant Vα24JαQ TCRα chain are decreased in patients with atopic diseases. Clin Exp Immunol. 2000;119(3):404-11.

Kumano K, Nakao A, Nakajima H, Miike S, Kurasawa K, Saito Y, Iwamoto I. Blockade of JAK2 by tyrphostin AG-490 inhibits antigen-induced eosinophil recruitment into the mouse airways. Biochem Biophys Res Commun. 2000;270(1):209-14.

Suzuki K, Nakajima H, Watanabe N, Kagami S-i, Suto A, Saito Y, Saito T, Iwamoto I. Role of common cytokine receptor γ chain (γc)- and Jak3-dependent signaling in the proliferation and survival of murine mast cells. Blood. 2000;96(6):2172-80.

Kawashima T, Hirose K, Satoh T, Kaneko A, Ikeda Y, Kaziro Y, Nosaka T, Kitamura T. MgcRacGAP is involved in the control of growth and differentiation of hematopoietic cells. Blood. 2000;96(6):2116-24.

• 原著論文
• 総説
• 著書
• 症例報告
• シンポジウム
• 学会発表
• 受賞
• deposit