研究業績
千葉大学大学院医学研究院
アレルギー・臨床免疫学
千葉大学病院
アレルギー・膠原病内科
Hattori K, Tanaka S, Hashiba D, Tamura J, Etori K, Kageyama T, Ito T, Meguro K, Iwata A, Suto A, Suzuki K, Nakamura J, Ohtori S, Ziegler SF, Nakajima H. Synovial regulatory T cells expressing ST2 deteriorate joint inflammation through the suppression of immunoregulatory eosinophils. J Autoimmun. 2024 Nov 6;149:103333. doi: 10.1016/j.jaut.2024.103333. Epub ahead of print. PMID: 39509740.
Suzuki J, Furuta S, Kameoka Y, Suzuki O, Ito F, Uno K, Kishi F, Yamakawa Y, Matsushita K, Miki T, Nakajima H, Suzuki K. Dynamics of scFv-targeted VAP2 correlating with IL-16, MIF and IL-1Ra in ANCA-associated vasculitis. Microvasc Res. 2024 Nov;156:104720. doi: 10.1016/j.mvr.2024.104720. Epub 2024 Aug 8. PMID: 39127096.
Miyamae T, Manabe Y, Sugihara T, Umezawa N, Yoshifuji H, Tamura N, Abe Y, Furuta S, Nagafuchi H, Ishizaki J, Nakano N, Atsumi T, Karino K, Amano K, Kurasawa T, Ito S, Yoshimi R, Ogawa N, Banno S, Naniwa T, Ito S, Hara A, Hirahara S, Uchida HA, Onishi Y, Murakawa Y, Komagata Y, Nakaoka Y, Harigai M. Pregnancy and childbirth in Takayasu arteritis in Japan: A nationwide retrospective study. Mod Rheumatol. 2024 Aug 8:roae068. doi: 10.1093/mr/roae068. Epub ahead of print. PMID: 39116014.
Karadag O, Bolek EC, Ayan G, Mohammad AJ, Grayson PC, Pagnoux C, Martín-Nares E, Monti S, Abe Y, Alberici F, Alibaz-Oner F, Cuthbertson D, Dagna L, Direskeneli H, Khalidi NA, Koening C, Langford CA, McAlear CA, Monach PA, Moroni L, Padoan R, Seo P, Warrington KJ, Hocevar A, Hinojosa-Azaola A, Furuta S, Emmi G, Ozen S, Jayne D, Merkel PA; GLOBAL‐PAN Collaborators. Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study. Arthritis Rheumatol. 2024 Jul;76(7):1120-1129. doi: 10.1002/art.42817. Epub 2024 Feb 22. PMID: 38343337.
Furuya H, Toda Y, Iwata A, Kanai M, Kato K, Kumagai T, Kageyama T, Tanaka S, Fujimura L, Sakamoto A, Hatano M, Suto A, Suzuki K, Nakajima H. Stage-specific GATA3 induction promotes ILC2 development after lineage commitment. Nat Commun. 2024 Jul 5;15(1):5610. doi: 10.1038/s41467-024-49881-y. PMID: 38969652.
Kumagai T, Iwata A, Furuya H, Kato K, Okabe A, Toda Y, Kanai M, Fujimura L, Sakamoto A, Kageyama T, Tanaka S, Suto A, Hatano M, Kaneda A, Nakajima H. A distal enhancer of GATA3 regulates Th2 differentiation and allergic inflammation. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2320727121. doi: 10.1073/pnas.2320727121. Epub 2024 Jun 26. PMID: 38923989.
Tanaka S, Yamamoto T, Iwata A, Kiuchi M, Kokubo K, Iinuma T, Sugiyama T, Hanazawa T, Hirahara K, Ikeda K, Nakajima H. Single-cell RNA sequencing of submandibular gland reveals collagen type XV-positive fibroblasts as a disease-characterizing cell population of IgG4-related disease. Arthritis Res Ther. 2024 Feb 20;26(1):55. doi: 10.1186/s13075-024-03289-7. PMID: 38378635; PMCID: PMC10877852.
Kojima S, Iwamoto T, Kobayashi Y, Kato M, Takizawa F, Ida T, Suzuki J, Toda Y, Miyachi K, Iwata A, Furuta S, Ikeda K, Nakajima H. Immunogenicity and influence on disease activity of recombinant zoster vaccine in patients with rheumatoid arthritis treated with DMARDs. RMD Open. 2024 Feb 21;10(1):e003902. doi: 10.1136/rmdopen-2023-003902. PMID: 38388170; PMCID: PMC10882334.
Furuya H, Nguyen CT, Chan T, Marusina AI, Merleev AA, Garcia-Hernandez ML, Hsieh SL, Tsokos GC, Ritchlin CT, Tagkopoulos I, Maverakis E, Adamopoulos IE. IL-23 induces CLEC5A+ IL-17A+ neutrophils and elicit skin inflammation associated with psoriatic arthritis. J Autoimmun. 2024 Jan 31;143:103167. doi: 10.1016/j.jaut.2024.103167. Epub ahead of print. PMID: 38301504.
Takeda R, Takahashi K, Kronbichler A, Akiyama D, Hanai S, Kobayashi Y, Matsuki A, Umibe T, Ito C, Sugimoto T, Sugiyama T, Yoshida S, Nishio Y, Nukui I, Nakashima A, Wakabayashi H, Asanuma K, Furuta S, Nakajima H, Nakagomi D. Development of a Kidney Prognostic Score in a Japanese Cohort of Patients With Antineutrophil Cytoplasmic Autoantibody Vasculitis. Kidney Int Rep. 2024 Jan 8;9(3):611-623. doi: 10.1016/j.ekir.2024.01.007. PMID: 38481514; PMCID: PMC10927481.
Kurihara S, Suzuki K, Yokota M, Ito T, Hayashi Y, Kikuchi R, Kageyama T, Meguro K, Tanaka S, Iwata A, Goto Y, Suto A, Nakajima H. Eosinophils Contribute to Oral Tolerance via Induction of RORγt-Positive Antigen-Presenting Cells and RORγt-Positive Regulatory T Cells. Biomolecules. 2024 Jan 10;14(1):89. doi: 10.3390/biom14010089. PMID: 38254689; PMCID: PMC10813120.
Ida T, Furuta S, Fujiwara M, Hiraguri M, Hirose K, Ikeda K, Iwamoto T, Kagami SI, Kobayashi Y, Kurasawa K, Nakagomi D, Oya Y, Sanayama Y, Shimizu T, Tamachi T, Umibe T, Yasui M, Nakajima H. Short-term and long-term outcomes of patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. Rheumatology (Oxford). 2024 Jan 12:keae011. doi: 10.1093/rheumatology/keae011. Epub ahead of print. PMID: 38216799.
Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, Umibe T, Kono H, Kurasawa K, Kita Y, Matsumura R, Kaneko Y, Ninagawa K, Hiromura K, Kagami SI, Inaba Y, Hanaoka H, Ikeda K, Nakajima H; LoVAS collaborators. Reduced-dose versus high-dose glucocorticoids added to rituximab on remission induction in ANCA-associated vasculitis: predefined 2-year follow-up study. Ann Rheum Dis. 2024 Jan 2;83(1):96-102. doi: 10.1136/ard-2023-224343. PMID: 37734880.
Ishikawa J, Suto A, Abe K, Hayashi Y, Suga K, Tanaka S, Kageyama T, Iwata A, Suzuki K, Suzuki K, Nakajima H. IL-21 is required for the maintenance and pathogenesis of murine Vγ4+ IL-17-producing γδT cells. Front Immunol. 2023 Aug 18;14:1211620. doi: 10.3389/fimmu.2023.1211620. PMID: 37662923; PMCID: PMC10473412.
Ida T, Ikeda K, Ohbe H, Nakamura K, Furuya H, Iwamoto T, Furuta S, Miyamoto Y, Nakajima M, Sasabuchi Y, Matsui H, Yasunaga H, Nakajima H. Early initiation of angiotensin-converting enzyme inhibitor in patients with scleroderma renal crisis: A nationwide inpatient database study. Rheumatology (Oxford). 2023 Jul 17:kead343. doi: 10.1093/rheumatology/kead343. Epub ahead of print. PMID: 37458488.
Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H. TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis. JCI Insight. 2023 May 22;8(10):e164778. doi: 10.1172/jci.insight.164778. PMID: 37212280; PMCID: PMC10322677.
Etori K, Tanaka S, Tamura J, Hattori K, Kagami SI, Nakamura J, Ohtori S, Nakajima H. Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients. Rheumatology (Oxford). 2023 Nov 2;62(11):3763-3769. doi: 10.1093/rheumatology/kead220. PMID: 37184877.
Smith RM, Jones RB, Specks U, Bond S, Nodale M, Al-Jayyousi R, Andrews J, Bruchfeld A, Camilleri B, Carette S, Cheung CK, Derebail V, Doulton T, Ferraro A, Forbess L, Fujimoto S, Furuta S, Gewurz-Singer O, Harper L, Ito-Ihara T, Khalidi N, Klocke R, Koening C, Komagata Y, Langford C, Lanyon P, Luqmani R, McAlear C, Moreland LW, Mynard K, Nachman P, Pagnoux C, Peh CA, Pusey C, Ranganathan D, Rhee RL, Spiera R, Sreih AG, Tesar V, Walters G, Wroe C, Jayne D, Merkel PA; RITAZAREM co-investigators. Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial. Ann Rheum Dis. 2023 Jul;82(7):937-944. doi: 10.1136/ard-2022-223559. Epub 2023 Mar 23. PMID: 36958796; PMCID: PMC10313987.
Sada KE, Kaname S, Higuchi T, Furuta S, Nagasaka K, Nanki T, Tsuboi N, Amano K, Dobashi H, Hiromura K, Bando M, Wada T, Arimura Y, Makino H, Harigai M. Validation of new ACR/EULAR 2022 classification criteria for anti-neutrophil cytoplasmic antibody-associated vasculitis. Mod Rheumatol. 2023 Dec 22;34(1):144-150. doi: 10.1093/mr/road017. PMID: 36715080.
Furuya H, Nguyen CT, Gu R, Hsieh SL, Maverakis E, Adamopoulos IE. Interleukin-23 Regulates Inflammatory Osteoclastogenesis via Activation of CLEC5A(+) Osteoclast Precursors. Arthritis Rheumatol. 2023 Aug;75(8):1477-1489. doi: 10.1002/art.42478. Epub 2023 Jun 6. PMID: 36787107; PMCID: PMC10423744.
Tanaka S, Etori K, Hattori K, Tamura J, Ikeda K, Kageyama T, Meguro K, Iwamoto T, Iwata A, Furuta S, Suto A, Suzuki K, Nakajima H. CCR4 predicts the efficacy of abatacept in rheumatoid arthritis patients through the estimation of Th17 and Treg cell abundance. Mod Rheumatol. 2023 Jul 31:road077. doi: 10.1093/mr/road077. Epub ahead of print. PMID: 37522614.
Kasuya T, Tanaka S, Tamura J, Etori K, Shoda J, Hattori K, Endo Y, Kitajima M, Kageyama T, Iwamoto T, Yokota M, Iwata A, Suto A, Suzuki K, Suzuki H, Ziegler SF, Nakajima H. Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake. Sci Rep. 2023 Jan 30;13(1):1653. doi: 10.1038/s41598-023-28987-1. PMID: 36717741; PMCID: PMC9887060.
Miyachi K, Iwamoto T, Kojima S, Ida T, Suzuki J, Yamamoto T, Mimura N, Sugiyama T, Tanaka S, Furuta S, Ikeda K, Suzuki K, Niewold TB, Nakajima H. Relationship of systemic type I interferon activity with clinical phenotypes, disease activity, and damage accrual in systemic lupus erythematosus in treatment-naive patients: a retrospective longitudinal analysis. Arthritis Res Ther. 2023 Feb 17;25(1):26. doi: 10.1186/s13075-023-03010-0. PMID: 36803843; PMCID: PMC9936752.
Abe K, Furuta S, Kobayashi Y, Sugiyama T, Kagami SI, Nakagomi D, Iwamoto T, Ikeda K, Nakajima H. Prognosis of spontaneous pneumomediastinum occurring in dermatomyositis or polymyositis patients with interstitial lung disease according to antimelanoma differentiation-associated gene 5 antibody status: a retrospective cohort study. RMD Open. 2023 Feb;9(1):e002770. doi: 10.1136/rmdopen-2022-002770. PMID: 36759007; PMCID: PMC9923350.
Mimura N, Iwamoto T, Furuta S, Ikeda K, Kobayashi Y, Nakamura T, Saku A, Kagami SI, Matsuki A, Takahashi K, Umibe T, Nakagomi D, Sanayama Y, Sugimoto T, Fukuta M, Hiraguri M, Kawashima H, Hirose K, Takatori H, Suehiro K, Takahashi S, Tamachi T, Kato M, Takizawa F, Kawarai Y, Hagiwara S, Nakamura J, Ohtori S, Nakajima H. Prevalence and risk factors of osteonecrosis of the femoral head in patients with ANCA-associated vasculitis: a multicentre cohort study. RMD Open. 2023 Feb;9(1):e002787. doi: 10.1136/rmdopen-2022-002787. PMID: 36849207; PMCID: PMC9972441.
Nagasaka K, Amano K, Dobashi H, Nagafuchi H, Sada KE, Komagata Y, Yamamura M, Kato M, Endo T, Nakaya I, Takeuchi T, Murakawa Y, Sugihara T, Saito M, Hayashi T, Furuta S, Tamura N, Karasawa K, Banno S, Endo S, Majima M, Kaname S, Arimura Y, Harigai M. Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: Effectiveness and safety in the first 6 months. Mod Rheumatol. 2023 Nov 1;33(6):1117-1124. doi: 10.1093/mr/roac150. PMID: 36478050.
Sugihara T, Uchida HA, Yoshifuji H, Maejima Y, Naniwa T, Katsumata Y, Okazaki T, Ishizaki J, Murakawa Y, Ogawa N, Dobashi H, Horita T, Tanaka Y, Furuta S, Takeuchi T, Komagata Y, Nakaoka Y, Harigai M. Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis. Mod Rheumatol. 2023 Nov 1;33(6):1145-1153. doi: 10.1093/mr/roac122. PMID: 36218378.
Shoda J, Tanaka S, Etori K, Hattori K, Kasuya T, Ikeda K, Maezawa Y, Suto A, Suzuki K, Nakamura J, Maezawa Y, Takemoto M, Betsholtz C, Yokote K, Ohtori S, Nakajima H. Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium. Arthritis Res Ther. 2022 Jun 4;24(1):134. doi: 10.1186/s13075-022-02817-7. PMID: 35659346; PMCID: PMC9166515.
Suzuki J, Furuta S, Sugiyama T, Iwamoto T, Ikeda K, Suzuki K, Nakajima H. Antiphospholipid antibody positivity and the thrombotic risk in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis. Mod Rheumatol. 2023 Mar 2;33(2):346-351. doi: 10.1093/mr/roac031. PMID: 35411394.
Nguyen CT, Furuya H, Das D, Marusina AI, Merleev AA, Ravindran R, Jalali Z, Khan IH, Maverakis E, Adamopoulos IE. Peripheral γδ T Cells Regulate Neutrophil Expansion and Recruitment in Experimental Psoriatic Arthritis. Arthritis Rheumatol. 2022 Sep;74(9):1524-1534. doi: 10.1002/art.42124. Epub 2022 Jul 21. PMID: 35320625; PMCID: PMC9427669.
Sugiyama T, Furuta S, Hiraguri M, Ikeda K, Inaba Y, Kagami SI, Kita Y, Kobayashi K, Kobayashi Y, Kurasawa K, Nakagomi D, Nawata Y, Kawasaki Y, Shiko Y, Sugiyama T, Nakajima H. Latent class analysis of 216 patients with adult-onset Still's disease. Arthritis Res Ther. 2022 Jan 3;24(1):7. doi: 10.1186/s13075-021-02708-3. PMID: 34980244; PMCID: PMC8722082.
Nakamura K, Ohbe H, Ikeda K, Uda K, Furuya H, Furuta S, Nakajima M, Sasabuchi Y, Matsui H, Fushimi K, Yasunaga H, Nakajima H. Intravenous cyclophosphamide in acute exacerbation of rheumatoid arthritis-related interstitial lung disease: A propensity-matched analysis using a nationwide inpatient database. Semin Arthritis Rheum. 2021 Oct;51(5):977-982. doi: 10.1016/j.semarthrit.2021.07.008. Epub 2021 Jul 13. PMID: 34403813.
Iwamoto T, Dorschner JM, Selvaraj S, Mezzano V, Jensen MA, Vsetecka D, Amin S, Makol A, Osborn T, Moder K, Chowdhary VR, Izmirly P, Belmont HM, Clancy RM, Buyon JP, Wu M, Loomis CA, Niewold TB. High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis. J Rheumatol. 2022 Apr;49(4):388-397. doi: 10.3899/jrheum.210391. Epub 2021 Nov 15. PMID: 34782453; PMCID: PMC8977285.
Suzuki K, Suzuki K, Yabe Y, Iida K, Ishikawa J, Makita S, Kageyama T, Iwamoto T, Tanaka S, Yokota M, Iwata A, Suto A, Nakajima H. NF-κB1 Contributes to Imiquimod-Induced Psoriasis-Like Skin Inflammation by Inducing Vγ4+Vδ4+γδT17 Cells. J Invest Dermatol. 2022 Jun;142(6):1639-1649.e5. doi: 10.1016/j.jid.2021.11.004. Epub 2021 Nov 11. PMID: 34774872.
Kageyama T, Ikeda K, Tanaka S, Taniguchi T, Igari H, Onouchi Y, Kaneda A, Matsushita K, Hanaoka H, Nakada TA, Ohtori S, Yoshino I, Matsubara H, Nakayama T, Yokote K, Nakajima H. Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan. Clin Microbiol Infect. 2021 Dec;27(12):1861.e1-1861.e5. doi: 10.1016/j.cmi.2021.07.042. Epub 2021 Aug 8. PMID: 34375755; PMCID: PMC8349446.
Fukuta M, Suzuki K, Kojima S, Yabe Y, Suzuki K, Iida K, Yamada H, Makino S, Iwata A, Tanaka S, Iwamoto T, Suto A, Nakagomi D, Wakashin H, Maezawa Y, Maezawa Y, Takemoto M, Asanuma K, Nakajima H. Suppressor of cytokine signalling 3 (SOCS3) expressed in podocytes attenuates glomerulonephritis and suppresses autoantibody production in an imiquimod-induced lupus model. Lupus Sci Med. 2021 May;8(1):e000426. doi: 10.1136/lupus-2020-000426. PMID: 34016718; PMCID: PMC8141454.
Cook L, Reid KT, Häkkinen E, de Bie B, Tanaka S, Smyth DJ, White MP, Wong MQ, Huang Q, Gillies JK, Ziegler SF, Maizels RM, Levings MK. Induction of stable human FOXP3+ Tregs by a parasite-derived TGF-β mimic. Immunol Cell Biol. 2021 Sep;99(8):833-847. doi: 10.1111/imcb.12475. Epub 2021 Jun 3. PMID: 33929751; PMCID: PMC8453874.
Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, Umibe T, Kono H, Kurasawa K, Kita Y, Matsumura R, Kaneko Y, Ninagawa K, Hiromura K, Kagami SI, Inaba Y, Hanaoka H, Ikeda K, Nakajima H; LoVAS Collaborators. Effect of Reduced-Dose vs High-Dose Glucocorticoids Added to Rituximab on Remission Induction in ANCA-Associated Vasculitis: A Randomized Clinical Trial. JAMA. 2021 Jun 1;325(21):2178-2187. doi: 10.1001/jama.2021.6615. PMID: 34061144; PMCID: PMC8170547.
Kubota A, Suto A, Suga K, Iwata A, Tanaka S, Suzuki K, Kobayashi Y, Nakajima H. Inhibition of Interleukin-21 prolongs the survival through the promotion of wound healing after myocardial infarction. J Mol Cell Cardiol. 2021 Oct;159:48-61. doi: 10.1016/j.yjmcc.2021.06.006. Epub 2021 Jun 16. PMID: 34144051.
Yokota M, Häffner N, Kassier M, Brunner M, Shambat SM, Brennecke F, Schniering J, Marques Maggio E, Distler O, Zinkernagel AS, Maurer B. Staphylococcus aureus impairs dermal fibroblast functions with deleterious effects on wound healing. FASEB J. 2021 Jul;35(7):e21695. doi: 10.1096/fj.201902836R. PMID: 34160101.
Furuya H, Nakajima M, Ikeda K, Nakamura K, Ohbe H, Aso S, Kumazawa R, Iwamoto T, Iwata A, Furuta S, Matsui H, Fushimi K, Yasunaga H, Nakajima H. Prognosis and Treatment of Myositis-Associated Severe Interstitial Lung Disease: A Descriptive Study Using a Nationwide Inpatient Database in Japan. Arthritis Care Res (Hoboken). 2022 Mar;74(3):478-483. doi: 10.1002/acr.24646. Epub 2022 Feb 2. PMID: 33973401.
Kato M, Ikeda K, Sugiyama T, Tanaka S, Iida K, Suga K, Nishimura N, Mimura N, Kasuya T, Kumagai T, Furuya H, Iwamoto T, Iwata A, Furuta S, Suto A, Suzuki K, Kawakami E, Nakajima H. Associations of ultrasound-based inflammation patterns with peripheral innate lymphoid cell populations, serum cytokines/chemokines, and treatment response to methotrexate in rheumatoid arthritis and spondyloarthritis. PLoS One. 2021 May 21;16(5):e0252116. doi: 10.1371/journal.pone.0252116. PMID: 34019595; PMCID: PMC8139502.